Imatinib restores expression of CD62L in BCR-ABL-positive cells

Journal of Leukocyte Biology

Volumn 73, Issue 5, 2003, Pages 600-603

  Fruehauf, S ^a   Topaly, J ^a   Schad, M ^b   Paschka, P ^c   Gschaidmeier, H ^d   Zeller, W J ^b   Hochhaus, A ^c   Ho, A D ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d NOVARTIS PHARMA GMBH   (Germany)

Author keywords

Adhesion molecule; Chronic myelogenous leukemia; Imatinib mesylate; L selectin

Indexed keywords

ABELSON KINASE; BCR ABL PROTEIN; IMATINIB; L SELECTIN; PROTEIN TYROSINE KINASE; RNA; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; MESSENGER RNA; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TUMOR MARKER; TUMOR PROTEIN;

ADVANCED CANCER; ARTICLE; BONE MARROW; CANCER PATIENT; CELL ADHESION; CELL LINE; CELL SURFACE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DATA ANALYSIS; DRUG MECHANISM; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS; VALIDATION PROCESS; BIOSYNTHESIS; CELL CULTURE; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MYELOID LEUKEMIA; PATHOLOGY; POLYMERASE CHAIN REACTION;

ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FUSION PROTEINS, BCR-ABL; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; L-SELECTIN; LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE; NEOPLASM PROTEINS; PIPERAZINES; POLYMERASE CHAIN REACTION; PYRIMIDINES; RNA, MESSENGER; RNA, NEOPLASM; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0037487137     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1002507     Document Type: Article

References (23)

1. Gordon, M. Y., Dowling, C. R., Riley, G. P., Goldman, J. M., Greaves, M. F. (1987) Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia. Nature 328, 342-344.
2. Verfaillie, C. M., McCarthy, J. B., McGlave, P. B. (1992) Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV. J. Clin. Invest. 90, 1232-1241.
3. Kawaishi, K., Kimura, A., Katoh, O., Sasaki, A., Oguma, N., Ihara, A., Satow, Y. (1996) Decreased L-selectin expression in CD34-positive cells from patients with chronic myelocytic leukaemia. Br. J. Haematol. 93, 367-374.
4. Bhatia, R., Wayner, E. A., McGlave, P. B., Verfaillie, C. M. (1994) Interferon-restores normal adhesion of chronic myelogenous leukemia hematopoietic progenitors to bone marrow stroma by correcting impaired beta1 integrin receptor function. J. Clin. Invest. 94, 384-391.
5. Upadhyaya, G., Guba, S. C., Sih, S. A., Feinberg, A. P., Talpaz, M., Kantarjian, H. M., Deisseroth, A. B., Emerson, S. G. (1991) Interferon-alpha restores the deficient expression of the cyloadhesion molecule lymphocyte function antigen-3 by chronic myelogenous leukemia progenitor cells. J. Clin. Invest. 88, 2131-2136.
6. Daley, G. Q., Van Etten, R. A., Baltimore, D. (1990) Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 247, 824-830.
7. Druker, B. J., Tamura, S., Buchdunger, E., Ohno, S., Segal, G. M., Fanning, S., Zimmermann, J., Lydon, N. B. (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat. Med. 2, 561-566.
8. Wertheim, J. A., Forsythe, K., Druker, B. J., Hammer, D., Boettiger, D., Pear, W. S. (2002) BCR-ABL-induced adhesion defects are tyrosine kinase-independent. Blood 99, 4122-4130.
9. Fruehauf, S., Srbic, K., Seggewiss, R., Topaly, J., Ho, A. D. (2002) Functional characterization of podia formation in normal and malignant hematopoietic cells. J. Leukoc. Biol. 71, 425-432.
10. Martin-Henao, G. A., Quiroga, R., Sureda, A., Gonzalez, J. R., Moreno, V., Garcia, J. (2000) L-selectin expression is low on CD34+ cells from patients with chronic myeloid leukemia and interferon-α-up-regulates this expression. Haematologica 85, 139-146.
11. Sawyers, C. L., Hochhaus, A., Feldman, E., Goldman, J. M., Miller, C. B., Ottmann, O. G., Schiffer, C. A., Talpaz, M., Guilhot, F., Deininger, M. W., Fischer, T., O'Brien, S. G., Stone, R. M., Gambacorti-Passerini, C. B., Russell, N. H., Reiffers, J. J., Shea, T. C., Chapuis, B., Coutre, S., Tura, S., Morra, E., Larson, R. A., Saven, A., Peschel, C., Gratwohl, A., Mandelli, F., Ben-Am, M., Gathmann, I., Capdeville, R., Paquette, R. L., Druker, B. J. (2002) Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood 99, 3530-3539.
12. Talpaz, M., Silver, R. T., Druker, B. J., Goldman, J. M., Gambacorti-Passerini, C., Guilhot, F., Schiffer, C. A., Fischer, T., Deininger, M. W., Lennard, A. L., Hochhaus, A., Ottmann, O. G., Gratwohl, A., Baccarani, M., Stone, R., Tura, S., Mahon, F. X., Fernandes-Reese, S., Gathmann, I., Capdeville, R., Kantarjian, H. M., Sawyers, C. L. (2002) Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood 99, 1928-1937.
13. Kantarjian, H., Sawyers, C., Hochhaus, A., Guilhot, F., Schiffer, C., Gambacorti-Passerini, C., Niederwieser, D., Resta, D., Capdeville, R., Zoellner, U., Talpaz, M., Druker, B., Goldman, J., O'Brien, S. G., Russell, N., Fischer, T., Ottmann, O., Cony-Makhoul, P., Facon, T., Stone, R., Miller, C., Tallman, M., Brown, R., Schuster, M., Loughran, T., Gratwohl, A., Mandelli, F., Saglio, G., Lazzarino, M., Russo, D., Baccarani, M., Morra, E. (2002) Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N. Engl. J. Med. 346, 645-652.
14. Topaly, J., Zeller, W. J., Fruehauf, S. (2001) Synergistic activity of the new ABL-specific tyrosine kinase inhibitor and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells. Leukemia 15, 342-347.
15. Hochhaus, A., Lin, F., Reiter, A., Skladny, H., Mason, P. J., van Rhee, F., Shepherd, P. C., Allan, N. C., Hehlmann, R., Goldman, J. M., Cross, N. C. (1996) Quantification of residual disease in chronic myelogenous leukemia patients on interferon-alpha therapy by competitive polymerase chain reaction. Blood 87, 1549-1555.
16. Krämer, A., Hörner, S., Willer, A., Fruehauf, S., Hochhaus, A., Hallek, M., Hehlmann, R. (1999) Adhesion to fibronectin stimulates proliferation of wild-type and bcr/abl-transfected murine hematopoietic cells. Proc. Natl. Acad. Sci. USA 96, 2087-2092.
17. Fruehauf, S., Veldwijk, M. R., Krämer, A., Haas, R., Zeller, W. J. (1998) Delineation of cell cycle state and correlation to adhesion molecule expression of human CD34+ cells from steady-state bone marrow and peripheral blood mobilized following G-CSF-supported chemotherapy. Stem Cells 16, 271-279.
18. Christopherson, I., Piechoki, M., Liu, G., Ratner, S., Galy, A. (2001) Regulation of L-selectin expression by a dominant negative Ikaros protein. J. Leukoc. Biol. 69, 675-683.
19. Gu, Y., Jia, B., Yang, F. C., D'Souza, M., Harris, C. E., Derrow, C. W., Zheng, Y., Williams, D. A. (2001) Biochemical and biological characterization of a human Rac2 GTPase mutant associated with phagocytic immunodeficiency. J. Biol. Chem. 276, 15929-15938.
20. Zuhn, I. E., Klinger, M., Karp, X., Kirk, H., Symons, M., Chrzanowska-Wodnicka, M., Der, C. J., Kay, R. J. (2000) G2A is an oncogenic G protein-coupled receptor. Oncogene 19, 3866-3877.
21. de Boer, F., Kessler, F. L., Netelenbos, T., Zweegman, S., Huijgens, P. C., van der Wall, E., van der Linden, J. A., Pinedo, H. M., Schuurhuis, G. J., Drager, A. M. (2002) Homing and clonogenic outgrowth of CD34(+) peripheral blood stem cells: a role for L-selectin? Exp. Hematol. 30, 590-597.
22. Dercksen, M. W., Gerritsen, W. R., Rodenhuis, S., Dirkson, M. K., Slaper-Cortenbach, I. C., Schaasberg, W. P., Pinedo, H. M., von dem Borne, A. E., van der School, C. E. (1995) Expression of adhesion molecules on CD34+ cells: CD34+ L-selectin+ cells predict a rapid platelet recovery after peripheral blood stem cell transplantation. Blood 85, 3313-3319.
23. Luscinskas, F. W., Kansas, G. S., Ding, H., Pizcueta, P., Schleiffenbaum, B. E., Tedder, T. F., Gimbrone Jr., M. A. (1994) Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins. J. Cell Biol. 125, 1417-1427.