Preparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2'-butylamino)-4H- and 3-(3'-methyl-2'-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 8, 1999, Pages 1513-1520

  Khelili, Smail ^a   De Tullio, Pascal ^a   Lebrun, Philippe ^b   Fillet, Marianne ^a   Antoine, Marie Hélène ^b   Ouedraogo, Raogo ^b   Dupont, Léon ^a   Fontaine, Jeanine ^b   Felekidis, Apostolos ^a   Leclerc, Gérard ^c   Delarge, Jacques ^a   Pirotte, Bernard ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c UNIV GRENOBLE ALPES   (France)

Author keywords

Optical isomers; Potassium channel openers; Pyridothiadiazine dioxides; Rat aorta; Rat pancreas

Indexed keywords

POTASSIUM CHANNEL STIMULATING AGENT; THIADIAZINE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENANTIOMER; ISOMER; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; TISSUE SPECIFICITY; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; AORTA; CELLS, CULTURED; CYCLIC N-OXIDES; CYCLIC S-OXIDES; DRUG EVALUATION; ION CHANNEL GATING; ISLETS OF LANGERHANS; MAGNETIC RESONANCE SPECTROSCOPY; POTASSIUM CHANNELS; PYRIDINES; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, INFRARED; STEREOISOMERISM; THIADIAZINES;

EID: 0032792738     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00082-6     Document Type: Article

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