Charge-charge interactions are key determinants of the pK values of ionizable groups in ribonuclease Sa (pI=3.5) and a basic variant (pI=10.2)

Journal of Molecular Biology

Volumn 325, Issue 5, 2003, Pages 1077-1092

  Laurents, Douglas V ^a,b,e   Huyghues Despointes, Beatrice M P ^a   Bruix, Marta ^b   Thurlkill, Richard L ^a   Schell, David ^a   Newsom, Stephanie ^a   Grimsley, Gerald R ^a   Shaw, Kevin L ^a,f   Treviño, Saul ^a   Rico, Manuel ^b   Briggs, James M ^c   Antosiewicz, Jan M ^d   Scholtz, J Martin ^a   Pace, C Nick ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^c University of Houston   (United States)

^d UNIVERSITY OF WARSAW   (Poland)

^e SAINT LOUIS UNIVERSITY   (United States)

^f GROVE CITY COLLEGE   (United States)

Author keywords

Coulomb's Law; Electrostatic interactions; pK; Poisson Boltzmann

Indexed keywords

RIBONUCLEASE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CALCULATION; CORRELATION ANALYSIS; DIELECTRIC CONSTANT; DIPOLE; ELECTRICITY; MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; PROTEIN STRUCTURE; RIBONUCLEASE SA;

EID: 0037474539     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)01273-1     Document Type: Article

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