-
1
-
-
0019256029
-
Chemistry of nitrosoureas: Intermediacy of 4,5-dihydro-1,2,3-oxadiazole in 1,3-bis-(2-chloroethyl)-1-nitrosourea decomposition
-
Brundrett R.B. Chemistry of nitrosoureas: intermediacy of 4,5-dihydro-1,2,3-oxadiazole in 1,3-bis-(2-chloroethyl)-1-nitrosourea decomposition. J. Med. Chem. 23:1980;1245-1247.
-
(1980)
J. Med. Chem.
, vol.23
, pp. 1245-1247
-
-
Brundrett, R.B.1
-
2
-
-
0025045171
-
Mechanism of action of (2-haloethyl)-nitrosoureas on DNA: Discrimination between alternative pathways of DNA base modification by 1,3-bis-(2-fluoroethyl)-1-nitrosourea by using specific deuterium labeling and identification of products by HPLC/Tandem mass spectrometry
-
Naghipur A., Ikonomou M.G., Kebarle P., Lown J.W. Mechanism of action of (2-haloethyl)-nitrosoureas on DNA: discrimination between alternative pathways of DNA base modification by 1,3-bis-(2-fluoroethyl)-1-nitrosourea by using specific deuterium labeling and identification of products by HPLC/Tandem mass spectrometry. J. Am. Chem. Soc. 112:1990;3178-3187.
-
(1990)
J. Am. Chem. Soc.
, vol.112
, pp. 3178-3187
-
-
Naghipur, A.1
Ikonomou, M.G.2
Kebarle, P.3
Lown, J.W.4
-
3
-
-
0025116511
-
DNA alkylation by the haloethylnitrosoureas: Nature of modifications produced and their enzymatic repair or removal
-
Ludlum D.B. DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal. Mutat. Res. 233:1990;117-126.
-
(1990)
Mutat. Res.
, vol.233
, pp. 117-126
-
-
Ludlum, D.B.1
-
4
-
-
0019126210
-
DNA crosslinking and mono-adduct repair in nitrosourea-treated human tumor cells
-
Erickson L.C., Laurent G., Sharkey N.A., Kohn K.W. DNA crosslinking and mono-adduct repair in nitrosourea-treated human tumor cells. Nature (London). 288:1980;727-729.
-
(1980)
Nature (London)
, vol.288
, pp. 727-729
-
-
Erickson, L.C.1
Laurent, G.2
Sharkey, N.A.3
Kohn, K.W.4
-
6
-
-
0026658165
-
Mutational specificity of 1,3-bis-(2-chloroethyl)-1-nitrosourea in a Chinese Hamster ovary cell line
-
Minnick D.T., Veigl M.L., Sedwick W.D. Mutational specificity of 1,3-bis-(2-chloroethyl)-1-nitrosourea in a Chinese Hamster ovary cell line. Cancer Res. 52:1992;4688-4695.
-
(1992)
Cancer Res.
, vol.52
, pp. 4688-4695
-
-
Minnick, D.T.1
Veigl, M.L.2
Sedwick, W.D.3
-
8
-
-
0022387877
-
N-methyl-N-nitrosourea potentiation of cytogenetic damage induced by 1,3-bis-(2-chloroethyl)-1-nitrosourea in normal human lymphocytes
-
Wiencke J.K., Bodell W.J. N-methyl-N-nitrosourea potentiation of cytogenetic damage induced by 1,3-bis-(2-chloroethyl)-1-nitrosourea in normal human lymphocytes. Cancer Res. 45:1985;4796-4803.
-
(1985)
Cancer Res.
, vol.45
, pp. 4796-4803
-
-
Wiencke, J.K.1
Bodell, W.J.2
-
9
-
-
0025081415
-
Molecular dosimetry for sister chromatid exchange induction and cytotoxicity by mono- and bi-functional alkylating agents
-
Bodell W.J. Molecular dosimetry for sister chromatid exchange induction and cytotoxicity by mono- and bi-functional alkylating agents. Mutat. Res. 233:1990;203-210.
-
(1990)
Mutat. Res.
, vol.233
, pp. 203-210
-
-
Bodell, W.J.1
-
10
-
-
13844323754
-
Genotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)
-
Wiencke J.K., Wiemels J. Genotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Mutat. Res. 339:1995;91-119.
-
(1995)
Mutat. Res.
, vol.339
, pp. 91-119
-
-
Wiencke, J.K.1
Wiemels, J.2
-
11
-
-
0020967477
-
Pre-treatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA inter-strand crosslinks not observed in cells treated with chloroethylnitrosourea alone
-
Zlotogorski C., Erickson L.C. Pre-treatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA inter-strand crosslinks not observed in cells treated with chloroethylnitrosourea alone. Carcinogenesis. 4:1983;759-763.
-
(1983)
Carcinogenesis
, vol.4
, pp. 759-763
-
-
Zlotogorski, C.1
Erickson, L.C.2
-
12
-
-
0023821613
-
6-methylguanine on DNA inter-strand crosslink formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)-methanesulfonate
-
6-methylguanine on DNA inter-strand crosslink formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)-methanesulfonate. Cancer Res. 48:1988;3603-3606.
-
(1988)
Cancer Res.
, vol.48
, pp. 3603-3606
-
-
Dolan, M.E.1
Pegg, A.E.2
Hora, N.K.3
Erickson, L.C.4
-
13
-
-
0023695431
-
Differences in DNA alkylation products formed in sensitive and resistant glioma cells treated with N-(2-chloroethyl)-N-nitrosourea
-
Bodell W.J., Tokuda K., Ludlum D.B. Differences in DNA alkylation products formed in sensitive and resistant glioma cells treated with N-(2-chloroethyl)-N-nitrosourea. Cancer Res. 48:1988;4489-4492.
-
(1988)
Cancer Res.
, vol.48
, pp. 4489-4492
-
-
Bodell, W.J.1
Tokuda, K.2
Ludlum, D.B.3
-
15
-
-
0026087923
-
Release of 7-alkylguanines from N-(2-chloroethyl)-N′-cyclohexyl-N-nitrosourea-modified DNA by 3-methyladenine DNA glycosylase II
-
Habraken Y., Carter C.A., Kirk M.C., Ludlum D.B. Release of 7-alkylguanines from N-(2-chloroethyl)-N′-cyclohexyl-N-nitrosourea-modified DNA by 3-methyladenine DNA glycosylase II. Cancer Res. 51:1991;499-503.
-
(1991)
Cancer Res.
, vol.51
, pp. 499-503
-
-
Habraken, Y.1
Carter, C.A.2
Kirk, M.C.3
Ludlum, D.B.4
-
16
-
-
0027136120
-
Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine glycosylase
-
Matijasevic Z., Boosalis M., Mackay W., Samson L. Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine glycosylase. Proc. Natl. Acad. Sci. U.S.A. 90:1993;11855-11859.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 11855-11859
-
-
Matijasevic, Z.1
Boosalis, M.2
Mackay, W.3
Samson, L.4
-
17
-
-
0032170023
-
Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA crosslinking agents
-
Allan J.M., Engelward B.P., Dreslin A.J., Wyatt M.D., Tomasz M., Samson L.D. Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA crosslinking agents. Cancer Res. 58:1998;3965-3973.
-
(1998)
Cancer Res.
, vol.58
, pp. 3965-3973
-
-
Allan, J.M.1
Engelward, B.P.2
Dreslin, A.J.3
Wyatt, M.D.4
Tomasz, M.5
Samson, L.D.6
-
18
-
-
0035852033
-
Induction of lacI mutations in Big Blue Rat-2 cells treated with 1-(2-hydroxyethyl)-1-nitrosourea: A model system for the analysis of mutagenic potential of the hydroxyethyl adducts produced by 1,3-bis-(2-chloroethyl)-1-nitrosourea
-
Sprung C.N., Wang Y., Miller D.L., Giannini D.D., Dhananjaya N., Bodell W.J. Induction of lacI mutations in Big Blue Rat-2 cells treated with 1-(2-hydroxyethyl)-1-nitrosourea: a model system for the analysis of mutagenic potential of the hydroxyethyl adducts produced by 1,3-bis-(2-chloroethyl)-1-nitrosourea. Mutat. Res. 484:2001;77-86.
-
(2001)
Mutat. Res.
, vol.484
, pp. 77-86
-
-
Sprung, C.N.1
Wang, Y.2
Miller, D.L.3
Giannini, D.D.4
Dhananjaya, N.5
Bodell, W.J.6
-
19
-
-
0031792320
-
Acute leukemia following treatment of malignant gliomas
-
Perry J.R., Brown M.T., Gockerman J.P. Acute leukemia following treatment of malignant gliomas. J. Neuro-Oncol. 40:1998;39-46.
-
(1998)
J. Neuro-Oncol.
, vol.40
, pp. 39-46
-
-
Perry, J.R.1
Brown, M.T.2
Gockerman, J.P.3
-
20
-
-
0033785953
-
Treatment related leukemia - A clinical and scientific challenge
-
Ng A., Taylor G.M., Eden O.B. Treatment related leukemia - a clinical and scientific challenge. Cancer Treat. Rev. 26:2000;377-391.
-
(2000)
Cancer Treat. Rev.
, vol.26
, pp. 377-391
-
-
Ng, A.1
Taylor, G.M.2
Eden, O.B.3
-
21
-
-
0018384262
-
Evidence for removal at different rates of O-ethyl pyrimidines and ethylphosphotriesters in two human fibroblast cell lines
-
Bodell W.J., Singer B., Thomas G.H., Cleaver J.E. Evidence for removal at different rates of O-ethyl pyrimidines and ethylphosphotriesters in two human fibroblast cell lines. Nucl. Acids Res. 6:1979;2819-2829.
-
(1979)
Nucl. Acids Res.
, vol.6
, pp. 2819-2829
-
-
Bodell, W.J.1
Singer, B.2
Thomas, G.H.3
Cleaver, J.E.4
-
22
-
-
0030992282
-
Detection of N7-(2-hydroxyethyl) guanine adducts in DNA and 9L cells treated with 1-(2-chloroethyl)-1-nitrosourea
-
Ye Q., Bodell W.J. Detection of N7-(2-hydroxyethyl) guanine adducts in DNA and 9L cells treated with 1-(2-chloroethyl)-1-nitrosourea. J. Chromatogr. B. 695:1997;65-70.
-
(1997)
J. Chromatogr. B
, vol.695
, pp. 65-70
-
-
Ye, Q.1
Bodell, W.J.2
-
23
-
-
0035486715
-
Levels of N7-(2-hydroxyethyl)guanine as a molecular dosimeter of drug delivery to human brain tumors
-
Bodell W.J., Giannini D.D., Hassenbusch S., Levin V.A. Levels of N7-(2-hydroxyethyl)guanine as a molecular dosimeter of drug delivery to human brain tumors. J. Neuro-Oncol. 3:2001;241-245.
-
(2001)
J. Neuro-Oncol.
, vol.3
, pp. 241-245
-
-
Bodell, W.J.1
Giannini, D.D.2
Hassenbusch, S.3
Levin, V.A.4
-
24
-
-
0021178261
-
Reduced level of DNA crosslinks and sister chromatid exchanges in 1,3-bis-(2-chloroethyl)-1-nitrosourea-resistant rat brain tumor cells
-
Bodell W.J., Rupniak H.T.R., Rasmussen J., Morgan W.F., Rosenblum M.L. Reduced level of DNA crosslinks and sister chromatid exchanges in 1,3-bis-(2-chloroethyl)-1-nitrosourea-resistant rat brain tumor cells. Cancer Res. 44:1984;3763-3767.
-
(1984)
Cancer Res.
, vol.44
, pp. 3763-3767
-
-
Bodell, W.J.1
Rupniak, H.T.R.2
Rasmussen, J.3
Morgan, W.F.4
Rosenblum, M.L.5
-
25
-
-
0021933377
-
Investigation of DNA crosslinking agents in 9L cells with different sensitivities to chloroethylnitrosoureas
-
Bodell W.J., Gerosa M., Aida T., Berger M.S., Rosenblum M.L. Investigation of DNA crosslinking agents in 9L cells with different sensitivities to chloroethylnitrosoureas. Cancer Res. 45:1985;3460-3464.
-
(1985)
Cancer Res.
, vol.45
, pp. 3460-3464
-
-
Bodell, W.J.1
Gerosa, M.2
Aida, T.3
Berger, M.S.4
Rosenblum, M.L.5
-
26
-
-
0027214571
-
1-2deoxyguanosinyl]-ethane in DNA reacted with 1-(2-chloroethyl)-1-nitrosourea
-
1-2deoxyguanosinyl]-ethane in DNA reacted with 1-(2-chloroethyl)-1-nitrosourea. Chem. Res. Toxicol. 6:1993;434-438.
-
(1993)
Chem. Res. Toxicol.
, vol.6
, pp. 434-438
-
-
Bodell, W.J.1
Pongracz, K.2
-
28
-
-
0024825701
-
Inhibition of a specific DNA repair system and nitrosourea cytotoxicity
-
Futscher B.F., Micetich K.C., Erickson L.C. Inhibition of a specific DNA repair system and nitrosourea cytotoxicity. Cancer Commun. 1:1989;65-73.
-
(1989)
Cancer Commun.
, vol.1
, pp. 65-73
-
-
Futscher, B.F.1
Micetich, K.C.2
Erickson, L.C.3
-
29
-
-
0025828948
-
6-methylguanine-DNA-methyltransferase activity and mRNA levels in HT-29 cells in vitro
-
6-methylguanine-DNA-methyltransferase activity and mRNA levels in HT-29 cells in vitro. Cancer Res. 51:1991;1581-1585.
-
(1991)
Cancer Res.
, vol.51
, pp. 1581-1585
-
-
Pieper, R.O.1
Futscher, B.W.2
Dong, Q.3
Erickson, L.C.4
-
30
-
-
0019833919
-
Tissue dependent enzyme mediated repair or removal of O-ethylpyrimidines and ethyl purines in carcinogen treated rats
-
Singer B., Spengler S., Bodell W.J. Tissue dependent enzyme mediated repair or removal of O-ethylpyrimidines and ethyl purines in carcinogen treated rats. Carcinogenesis. 2:1981;1069-1073.
-
(1981)
Carcinogenesis
, vol.2
, pp. 1069-1073
-
-
Singer, B.1
Spengler, S.2
Bodell, W.J.3
-
31
-
-
0037172798
-
Endogenous DNA lesions can inhibit the binding of the AP-1 (c-Jun) transcription factor
-
Rogstad D.K., Liu P., Burdzy A., Lin S.S., Sowers L.C. Endogenous DNA lesions can inhibit the binding of the AP-1 (c-Jun) transcription factor. Biochemistry. 41:2002;8093-8102.
-
(2002)
Biochemistry
, vol.41
, pp. 8093-8102
-
-
Rogstad, D.K.1
Liu, P.2
Burdzy, A.3
Lin, S.S.4
Sowers, L.C.5
-
32
-
-
0032782907
-
Overexpression of cDNA encoding FANCC, SPHAR, MPG, SNM1 or HA 3611 does not render CHO cells more resistant to DNA crosslinking agents
-
Grombacher T., Tomicic M., Digweed M., Kaina B. Overexpression of cDNA encoding FANCC, SPHAR, MPG, SNM1 or HA 3611 does not render CHO cells more resistant to DNA crosslinking agents. Anticancer Res. 19:1999;1729-1736.
-
(1999)
Anticancer Res.
, vol.19
, pp. 1729-1736
-
-
Grombacher, T.1
Tomicic, M.2
Digweed, M.3
Kaina, B.4
-
33
-
-
0032892044
-
DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents
-
Glassner B.J., Weeda G., Allan J.M., Broekhof J.L.M., Carls N.H.E., Donker I., Engelward B.P., Hampson R.J., Hersmus R., Hickman M.J., Roth R.B., Warren H.B., Wu M.M., Hoeijmakers J.H.J., Samson L.D. DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents. Mutagenesis. 14:1999;339-347.
-
(1999)
Mutagenesis
, vol.14
, pp. 339-347
-
-
Glassner, B.J.1
Weeda, G.2
Allan, J.M.3
Broekhof, J.L.M.4
Carls, N.H.E.5
Donker, I.6
Engelward, B.P.7
Hampson, R.J.8
Hersmus, R.9
Hickman, M.J.10
Roth, R.B.11
Warren, H.B.12
Wu, M.M.13
Hoeijmakers, J.H.J.14
Samson, L.D.15
-
34
-
-
0036570062
-
Clinical relevance of MGMT in the treatment of cancer
-
Gerson S.L. Clinical relevance of MGMT in the treatment of cancer. J. Clin. Oncol. 20:2002;2388-2399.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 2388-2399
-
-
Gerson, S.L.1
-
35
-
-
0029665878
-
4-methylthymine, or the cis-platin-d(GpG) adduct
-
4-methylthymine, or the cis-platin-d(GpG) adduct. Proc. Natl. Acad. Sci. U.S.A. 93:1966;6443-6447.
-
(1966)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 6443-6447
-
-
Duckett, D.R.1
Drummond, J.T.2
Murchie, A.I.3
Reardon, J.T.4
Sancar, A.5
Lilley, D.M.6
Modrich, P.7
|