Low expression levels of p27 correlate with loco-regional recurrence in nasopharyngeal carcinoma

Cancer Letters

Volumn 189, Issue 2, 2003, Pages 231-236

  Hwang, Chung Feng ^a   Su, Chih Ying ^a   Huang, Shung Chen ^a   Huang, Chao Cheng ^a   Fang, Fu Min ^a   Lui, Chun Chung ^a   Chang, Hsueh Wen ^b   Cho, Chung Lung ^b  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

c myc; Nasopharyngeal carcinoma; p27

Indexed keywords

ANTINEOPLASTIC AGENT; MYC PROTEIN; PROTEIN P27;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER RECURRENCE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CANCER; NECK METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; HEAD AND NECK NEOPLASMS; HUMANS; LIFE TABLES; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NEOPLASM RECURRENCE, LOCAL; PROTO-ONCOGENE PROTEINS C-MYC; SURVIVAL ANALYSIS; TAIWAN; TUMOR SUPPRESSOR PROTEINS;

EID: 0037469088     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(02)00508-6     Document Type: Article

References (27)

1. Vokes E.E., Liebowitz D.N., Weichselbaum R.R. Nasopharyngeal carcinoma. Lancet. 350:1997;1087-1091.
2. Kwong D.L.W., Nicholls J., Wei W.I., Chua D.T., Sham J.S., Yuen P.W., Cheng A.C., Wan K.Y., Kwong P.W., Choy D.T. The time course of histologic remission after treatment of patients with nasopharyngeal carcinoma. Cancer. 85:1999;1446-1453.
3. Cheng S.H., Liu T.W., Jian J.J., Tsai S.Y., Hao S.P., Huang C.H., Liu M.C., Yu B., Huang A.T. Concomitant chemotherapy and radiotherapy for locally advanced nasopharyngeal carcinoma. Cancer J. Sci. Am. 3:1997;100-106.
4. Coco-Martin J.M., Balkenende A., Verschoor T., Lallemand F., Michalides R. Cyclin D1 overexpression enhances radiation-induced apoptosis and radiosensitivity in a breast tumor cell line. Cancer Res. 59:1999;1134-1140.
5. INK4a on chemosensitivity in nasopharyngeal carcinoma cells. Int. J. Oncol. 17:2000;135-140.
6. Toyoshima H., Hunter T. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell. 78:1994;67-74.
7. Esposito V., Baldi A., De-Luca A., Groger A.M., Loda M., Giordano G.G., Caputi M., Baldi F., Pagano M., Giordano A. Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer. Cancer Res. 57:1997;3381-3385.
8. Bouchard C., Thieke K., Maier A., Saffrich R., Hanley-Hyde J., Ansorge W., Reed S., Sicinski P., Bartek J., Eilers M. Direct induction of cyclin D2 by Myc contributes to cell cycle induction and sequestration of p27. EMBO J. 18:1999;5321-5333.
9. O'Hagan R.C., Ohh M., David G., de Alboran I.M., Alt F.W., Kaelin W.G.Jr., DePinho R.A. Myc-enhanced expression of Cul1 promoted ubiquitin-dependent proteolysis and cell cycle progression. Genes Dev. 14:2000;2185-2191.
10. Catzavelos C., Bhattacharya N., Ung Y.C., Wilson J.A., Roncari L., Sandhu C., Shaw P., Yeger H., Morava-Protzner I., Kapusta L., Franssen E., Pritchard K.I., Slingerland J.M. Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer. Nat. Med. 3:1997;227-230.
11. Heerdt B.G., Molinas S., Deitch D., Augenlicht L.H. Aggressive subtypes of human colorectal tumors frequently exhibit amplification of the c-myc gene. Oncogene. 6:1991;125-129.
12. Venkatesan T.K., Kuropkat C., Caldarelli D.D., Panje W.R., Hutchinson J.C. Jr, Chen S., Coon J.S. Prognostic significance of p27 expression in carcinoma of the oral cavity and oropharynx. Laryngoscope. 109:1999;1329-1333.
13. Gapany M., Pavelic Z.P., Kelley D.J., Pavelic L., Gapany S.R., Craven J.M., Stambrook P.J., Gluckman J.L. Immunohistochemical detection of c-myc protein in head and neck tumors. Arch. Otolaryngol. Head Neck Surg. 120:1994;255-259.
14. Shanmugaratnam K., Chan S.H., de-Thé G., Goh J.E., Khor T.H., Simons M.J., Tye C.Y. Histopathology of nasopharyngeal carcinoma: correlations with epidemiology, survival rates and other biological characteristics. Cancer. 44:1979;1029-1044.
15. Sobin L.H., Wittekind C. International Union Against Cancer (UICC): TNM Classification of Malignant Tumors, 5th Edition. 1977;15-50 Wiley-Liss, New York.
16. Porter M.J., Field J.K., Leung S.F., Lo D., Lee J.C., Spandidos D.A., van Hasselt C.A. The detection of the c-myc and ras oncogenes in nasopharyngeal carcinoma by immunohistochemistry. Acta Otolaryngol. 114:1994;105-109.
17. Tan P., Cady B., Wanner M., Worland P., Cukor B., Magi-Galluzzi C., Lavin P., Draetta G., Pagano M., Loda M. The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a, b) invasive breast carcinomas. Cancer Res. 57:1997;1259-1263.
18. Loda M., Cukor B., Tam S.W., Lavin P., Fiorentino M., Draetta G.F., Jessup J.M., Pagano M. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat. Med. 3:1997;231-234.
19. Fan C.S., Wong N., Leung S.F., To K.F., Lo K.W., Lee S.W., Mok T.S., Johnson P.J., Huang D.P. Frequent c-myc and Int-2 overrepresentations in nasopharyngeal carcinoma. Hum. Pathol. 31:2000;169-178.
20. Wong S.C., Chan J.K., Lee K.C., Hsiao W.L. Differential expression of p16/p21/p27 and cyclin D1/D3, and their relationships to cell proliferation, apoptosis, and tumour progression in invasive ductal carcinoma of the breast. J. Pathol. 194:2001;35-42.
21. Bergmann E., Wanzel M., Weber A., Shin I., Christiansen H., Eilers M. Expression of P27(KIP1) is prognostic and independent of MYCN amplification in human neuroblastoma. Int. J. Cancer. 95:2001;176-183.
22. Khoo M.L., Beasley N.J., Ezzat S., Freeman J.L., Asa S.L. Overexpression of cyclin D1 and underexpression of p27 predict lymph node metastases in papillary thyroid carcinoma. J. Clin. Endocrinol. Metab. 87:2002;1814-1818.
23. Lee A.W., Law S.C., Foo W., Poon Y.F., Cheung F.K., Chan D.K., Tung S.Y., Thaw M., Ho J.H. Retrospective analysis of patients with nasopharyngeal carcinoma treated during 1976-1985: survival after local recurrence. Int. J. Radiat. Oncol., Biol., Phys. 26:1993;773-782.
24. Yamashita S., Kondo M., Hashimoto S. Squamous cell carcinoma of the nasopharynx: an analysis of failure patterns after radiation therapy. Acta Radiol. Oncol. 24:1985;315-320.
25. Pavelic Z.P., Steele P., Preisler H.D. Evaluation of c-myc proto-oncogene in primary human breast carcinomas. Anticancer Res. 11:1991;1421-1427.
26. Sikora K., Chan S., Evan G., Gabra H., Markham N., Stewart J., Watson J. c-myc oncogene expression in colorectal cancer. Cancer. 59:1987;1289-1295.
27. Polacarz S.V., Hey N.A., Stephenson T.J., Hill A.S. c-myc oncogene product p62 c-myc in ovarian mucinous neoplasms. J. Clin. Pathol. 42:1989;171-176.