Prolonged shedding of multidrug-resistant influenza A virus in an immunocompromised patient [8]

New England Journal of Medicine

Volumn 348, Issue 9, 2003, Pages 867-868

  Weinstock, David M ^a   Gubareva, Larisa V ^b   Zuccotti, Gianna ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; OSELTAMIVIR; RIMANTADINE; ZANAMIVIR;

ACUTE LYMPHOCYTIC LEUKEMIA; ADULT; AVASCULAR NECROSIS; CASE REPORT; COUGHING; FEVER; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNE DEFICIENCY; INFECTION CONTROL; INFLUENZA VIRUS A; KIDNEY DISEASE; LETTER; LUNG DISEASE; MALE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RHINORRHEA; VIRUS SHEDDING;

ADULT; DRUG RESISTANCE, MULTIPLE; FATAL OUTCOME; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOCOMPROMISED HOST; INFLUENZA A VIRUS; INFLUENZA, HUMAN; LEUKEMIA, LYMPHOCYTIC, ACUTE; MALE; VIRUS SHEDDING;

EID: 0037468417     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200302273480923     Document Type: Letter

References (5)

1. Boivin G, Goyette N, Bernatchez H. Prolonged excretion of amantadine-resistant influenza A virus quasi species after cessation of antiviral therapy in an immunocompromised patient. Clin Infect Dis 2002;34:E23-E25.
2. Klimov AI, Rocha E, Hayden FG, Shult PA, Roumillat LF, Cox NJ. Prolonged shedding of amantadine-resistant influenza A viruses by immunodeficient patients: detection by polymerase chain reaction-restriction analysis. J Infect Dis 1995;172:1352-5.
3. Gubareva LV, Webster RG, Hayden FG. Comparison of the activties of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants. Antimicrob Agents Chemother 2001;45:3403-8.
4. Ives JA, Carr JA, Mendel DB, et al. The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leaves virus severely compromised both in vitro and in vivo. Antiviral Res 2002;55:307-17.
5. Gubareva LV, Kaiser L, Matrosovich MN, Soo-Hoo Y, Hayden FG. Selection of influenza virus mutants in experimentally infected volunteers treated with oseltamivir. J Infect Dis 2001;183:523-31.