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For leading references to previous work on miniature proteins that are well-folded or bind macromolecular targets, see: (a) Braisted, A. C.; Wells, J. A. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 5688-5692. (b) Lombardi, A.; Bryson, J. W.; Ghirlanda, G.; DeGrado, W. F. J. Am. Chem. Soc. 1997, 119, 12378-12379. (c) Imperiali, B.; Ottesen. J. J. Biopolymers 1998, 47, 23-29. (d) DeGrado, W. F.; Summa, C. M.; Pavone, V.; Nastri, F.; Lombardi, A. Annu. Rev. Biochem. 1999, 68, 779-819. (e) Skerra, A. J. Mol. Recognit. 2000, 13, 167-187. (f) Cochran, A. G.; Skelton, N. J.; A., S. M. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 5578-5583. (g) Beerli, R. R.; Barbas, C. F. Nat. Biotechnol. 2002, 20, 135-141.
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For leading references to previous work on miniature proteins that are well-folded or bind macromolecular targets, see: (a) Braisted, A. C.; Wells, J. A. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 5688-5692. (b) Lombardi, A.; Bryson, J. W.; Ghirlanda, G.; DeGrado, W. F. J. Am. Chem. Soc. 1997, 119, 12378-12379. (c) Imperiali, B.; Ottesen. J. J. Biopolymers 1998, 47, 23-29. (d) DeGrado, W. F.; Summa, C. M.; Pavone, V.; Nastri, F.; Lombardi, A. Annu. Rev. Biochem. 1999, 68, 779-819. (e) Skerra, A. J. Mol. Recognit. 2000, 13, 167-187. (f) Cochran, A. G.; Skelton, N. J.; A., S. M. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 5578-5583. (g) Beerli, R. R.; Barbas, C. F. Nat. Biotechnol. 2002, 20, 135-141.
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For leading references to previous work on miniature proteins that are well-folded or bind macromolecular targets, see: (a) Braisted, A. C.; Wells, J. A. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 5688-5692. (b) Lombardi, A.; Bryson, J. W.; Ghirlanda, G.; DeGrado, W. F. J. Am. Chem. Soc. 1997, 119, 12378-12379. (c) Imperiali, B.; Ottesen. J. J. Biopolymers 1998, 47, 23-29. (d) DeGrado, W. F.; Summa, C. M.; Pavone, V.; Nastri, F.; Lombardi, A. Annu. Rev. Biochem. 1999, 68, 779-819. (e) Skerra, A. J. Mol. Recognit. 2000, 13, 167-187. (f) Cochran, A. G.; Skelton, N. J.; A., S. M. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 5578-5583. (g) Beerli, R. R.; Barbas, C. F. Nat. Biotechnol. 2002, 20, 135-141.
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25
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0242548129
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note
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3 internuclear phosphate.
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28
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0242464578
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note
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See Supporting Information for details.
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