Engrailed (Gln50→Lys) homeodomain-DNA complex at 1.9 Å resolution: Structural basis for enhanced affinity and altered specificity

Structure

Volumn 5, Issue 8, 1997, Pages 1047-1054

  Tucker Kellogg, Lisa ^a   Rould, Mark A ^b,c   Chambers, Kristen A ^b,c   Ades, Sarah E ^c   Sauer, Robert T ^c   Pabo, Carl O ^b,c  

^a USA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Altered specificity mutation; DNA binding; Homeodomain; Protein DNA interactions; X ray crystallography

Indexed keywords

EUKARYOTA;

ASPARAGINE; DNA; ENGRAILED HOMEOBOX PROTEINS; HOMEODOMAIN PROTEIN; LYSINE; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DROSOPHILA; HYDROGEN BOND; MUTATION; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ASPARAGINE; CRYSTALLOGRAPHY, X-RAY; DNA; DROSOPHILA; HOMEODOMAIN PROTEINS; HYDROGEN BONDING; LYSINE; MODELS, MOLECULAR; MUTATION; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; TRANSCRIPTION FACTORS;

EID: 0030609996     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(97)00256-6     Document Type: Article

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