Pharmacological evidence for a correlation between hippocampal CA1 cell damage and hyperlocomotion following global cerebral ischemia in gerbils

European Journal of Pharmacology

Volumn 467, Issue 1-3, 2003, Pages 103-109

  Katsuta, Kiyotaka ^a   Umemura, Kazuo ^b   Ueyama, Noriko ^a   Matsuoka, Nobuya ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

(Mongolian gerbil); Cerebral ischemia; Delayed neuronal death; Global ischemia; Hippocampus; Locomotor activity; Neuroprotective drug

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; 4 PHOSPHONOMETHYLPIPECOLIC ACID; 6 (1 IMIDAZOLYL) 7 NITRO 2,3 QUINOXALINEDIONE; ACETYLSALICYLIC ACID; ALPHA [4 (4 FLUOROBENZOYL) 1 PIPERIDYL] 2 ACETONAPHTHONE; CLONIDINE; DIZOCILPINE; ELIPRODIL; NEUROPROTECTIVE AGENT; NIZOFENONE; PENTOBARBITAL; PHENCYCLIDINE; PIROXICAM; TACROLIMUS; TICLOPIDINE; VINPOCETINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CAROTID ARTERY LIGATION; CELL DEATH; CELL LOSS; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; GERBIL; HIPPOCAMPUS; HYPERACTIVITY; LOCOMOTION; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0037466444     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(03)01573-5     Document Type: Article

References (29)

1. Babcock A.M., Baker D.A., Lovec R. Locomotor activity in the ischemic gerbils. Brain Res. 625:1993;351-354.
2. 2+ channels and in gerbil global cerebral ischaemia. Eur. J. Pharmacol. 299:1996;103-112.
3. Bickler P.E., Hansen B.M. Alpha 2-adrenergic agonists reduce glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices during hypoxia. Neuropharmacology. 35:1996;679-687.
4. Boast C.A., Gerhardt S.C., Pastor G., Lehmann J., Etienne P.E., Liebman J.M. The N-methyl-D-aspartate antagonists CGS19755 and CPP reduce ischemic brain damage in gerbils. Brain Res. 442:1988;345-348.
5. Chandler M.J., DeLeo J., Carney J.M. An unanesthetized-gerbil model of cerebral ischemia-induced behavioural changes. J. Pharmacol. Methods. 14:1985;137-146.
6. Choi D.W. Excitotoxic cell death. J. Neurobiol. 23:1992;1261-1276.
7. Contreras P.C., Ragan D.M., Bremer M.E., Lanthorn T.H., Gray N.M., Iyengar S., Jacobson A.E., Rice K.C., de Costa B.R. Evaluation of U-50,488H analogs for neuroprotective activity in the gerbil. Brain Res. 546:1991;79-82.
8. Corbett D., Evans S.J., Nurse S.M. Impaired acquisition of the Morris water maze following global ischemic damage in the gerbils. NeuroReport. 3:1992;204-206.
9. Dietrich W.D., Busto R., Globus M.Y., Ginsberg M.D. Brain damage and temperature: cellular and molecular mechanisms. Adv. Neurol. 71:1996;177-197.
10. Furuichi Y., Katsuta K., Maeda M., Ueyama N., Moriguchi A., Matsuoka N., Goto T., Yanagihara T. Neuroprotective action of tacrolimus (FK506) in focal and global cerebral ischemia in rodents: dose dependency, therapeutic time window and long-term efficacy. Brain Res. 965:2003;137-145.
11. Gerhardt S.C., Boast C.A. Motor activity changes following cerebral ischemia in gerbils are correlated with the degree of neuronal degeneration in hippocampus. Behav. Neurosci. 102:1988;301-303.
12. Gill R., Foster A.C., Woodruff G.N. MK-801 is neuroprotective in gerbils when administered during the post-ischemic period. Neuroscience. 25:1988;847-855.
13. Iadecola C., Alexander M. Cerebral ischemia and inflammation. Curr. Opin. Neurol. 14:2001;89-94.
14. Ide T., Morikawa E., Kirino T. An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the Mongolian gerbil. Neurosci. Lett. 204:1996;157-160.
15. Judge M.E., Sheardown M.J., Jacobsen P., Honore T. Protection against post-ischemic behavioral pathology by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX) in the gerbil. Neurosci. Lett. 133:1991;291-294.
16. Kaneko T., Nakazawa T., Ueno M., Furuya Y., Ikeda M., Mihara M., Abe K., Tanaka K., Uzuo T., Fukuda T., Sugimoto H., Yamatsu K. Anti-ischemic effect of the novel anti-ischemic agent 2-(4-(p-fluorobenzoyl)-piperidin-1-yl)-2′-acetonaphthone hydrochloride and possible mechanism of its action. Arzneimittelforschung. 39:1989;445-450.
17. Karasawa Y., Araki H., Otomo S. Changes in locomotor activity and passive avoidance task performance induced by cerebral ischemia in Mongolian gerbils. Stroke. 25:1994;645-650.
18. Kawasaki-Yatsugi S., Yatsugi S., Koshiya K., Shimizu-Sasamata M. Neuroprotective effect of YM90K, an AMPA-receptor antagonist, against delayed neuronal death induced by transient global cerebral ischemia in gerbils and rats. Jpn. J. Pharmacol. 74:1997;253-260.
19. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239:1982;57-69.
20. Kirino T., Sano K. Selective vulnerability in the gerbil hippocampus following transient ischemia. Acta Neuropathol. 62:1984;201-208.
21. Kuroiwa T., Bonnekoh P., Hossmann K.-A. Locomotor hyperactivity and hippocampal CA1 injury after transient forebrain ischemia of gerbils. Neurosci. Lett. 122:1991;141-144.
22. Maeda M., Furuichi Y., Ueyama N., Moriguchi A., Satoh N., Matsuoka N., Goto T., Yanagihara T. A combined treatment with tacrolimus (FK506) and recombinant tissue plasminogen activator for thrombotic focal cerebral ischemia in rats: increased neuroprotective efficacy and extended therapeutic time window. J. Cereb. Blood Flow Metab. 22:2002;1205-1211.
23. Matsuda S., Wen T.-C., Morita F., Ohtsuka H., Igase K., Yoshimura H., Sakanaka M. Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils. Neurosci. Lett. 204:1996;109-112.
24. Matsumoto Y., Aihara K., Kamata T., Goto N. Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation. Eur. J. Pharmacol. 262:1994;157-161.
25. Mileson B.E., Schwartz R.D. The use of locomotor activity as a behavioral screen for neuronal damage following transient forebrain ischemia in gerbils. Neurosci. Lett. 128:1991;71-76.
26. Nakagomi T., Sasaki T., Kirino T., Tamura A., Noguchi M., Saito I., Takakura K. Effect of cyclooxygenase and lipoxygenase inhibitors on delayed neuronal death in the gerbil hippocampus. Stroke. 20:1989;925-929.
27. Nakanishi H., Katsuta K., Koide T., Ueda Y., Shirakawa K., Yoshida K. Protective effect of FR115427 against ischemic hippocampal damage in gerbils. Jpn. J. Pharmacol. 64:1994;189-193.
28. Simon R.P., Swan J.H., Griffiths T., Meldrum B.S. Blockade of NMDA receptors may protect against ischemic damage in the brain. Science. 226:1984;850-852.
29. Wang D., Corbett D. Cerebral ischemia, locomotor activity and spatial mapping. Brain Res. 533:1990;78-82.