Effects of acute and repeated daily exposure to hypergravity on spatial learning in mice

Neuroscience Letters

Volumn 336, Issue 3, 2003, Pages 147-150

  Mandillo, Silvia ^a   Del Signore, Arianna ^a   Paggi, Paola ^a   Francia, Nadia ^b   Santucci, Daniela ^b   Mele, Andrea ^a   Oliverio, Alberto ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Cognitive deficits; Gravity; Memory; Open field with objects; Rotation; Spatial learning

Indexed keywords

ACCELERATION; ANIMAL EXPERIMENT; ARTICLE; CENTRIFUGE; COGNITION; CONTROLLED STUDY; DISCRIMINATION LEARNING; EXPLORATORY BEHAVIOR; EXPOSURE; GRAVITY; LEARNING; LEARNING DISORDER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ROTATION; SPATIAL MEMORY; SPATIAL ORIENTATION; TASK PERFORMANCE; WALKING;

EID: 0037461573     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)01282-X     Document Type: Article

References (17)

1. Benke T., Koserenko O., Watson N.V., Gerstenbrand F. Space and cognition: the measurement of behavioral functions during a 6 day space mission. Aviat. Space Environ. Med. 64:1993;376-379.
2. Fowler B., Comfort D., Bock O. A review of cognitive and perceptual-motor performance in space. Aviat. Space Environ. Med. 71:(9):2000;A66-A68.
3. Glasauer S., Mittelstaedt H. Perception of spatial orientation in different g-levels. J. Gravitat. Physiol. 4:1998;P5-P8.
4. GustaveDitDuflo S., Gestreau C., Lacour M. Fos expression in the rat brain after exposure to gravito-inertial force changes. Brain Res. 861:2000;333-344.
5. Knierim J.J., McNaughton B.L., Poe G.R. Three-dimensional spatial selectivity of hippocampal neurons during space flight. Nat. Neurosci. 3:2000;209-210.
6. Manzey D., Lorenz B. Mental performance during short-term and long-term spaceflight. Brain Res. Rev. 28:1998;215-221.
7. Manzey D., Lorenz B., Polyakov V.V. Mental performance in extreme environments: results from a performance monitoring study during a 438 day space mission. Ergonomics. 41:1998;537-539.
8. McIntyre J., Zago M., Berthoz A., Lacquaniti F. Does the brain model Newton's laws? Nat. Neurosci. 4:2001;693-694.
9. Morey E.R., Baylink D.J. Inhibition of bone formation during space flights. Science. 201:1978;1138-1141.
10. Newberg A.B., Alavi A. Changes in the central nervous system during long-duration space flight: implications for neuro-imaging. Adv. Space Res. 22:1998;185-196.
11. Pompeiano O., D'Ascanio P., Centini C., Pompeiano M., Girelli C., Tononi G. Immediate early gene expression in the vestibular nuclei and related vegetative areas in rats during space flight. Acta Otolaryngol. 121:2001;120-126.
12. Pozzo T., Papaxanthis C., Stapley P., Berthoz A. The sensorimotor and cognitive integration of gravity. Brain Res. Rev. 28:1998;92-101.
13. Reschke M.F., Bloomberg J.J., Harm D.L., Paloski W.H., Layne C., McDonald V. Posture, locomotion, spatial orientation, and motion sickness as a function of space flight. Brain Res. Rev. 28:1998;102-117.
14. Roullet P., Mele A., Ammassari-Teule M. Involvement of glutamatergic and dopaminergic systems in the reactivity of mice to spatial and non-spatial change. Psychopharmacology. 126:1996;55-61.
15. Santucci D., Corazzi G., Francia N., Antonelli A., Aloe L., Alleva E. Neurobehavioural effects of hypergravity conditions in the adult mouse. NeuroReport. 11:2000;3353-3356.
16. Stackman R.W., Clark A.S., Taube J.S. Hippocampal spatial representations require vestibular input. Hippocampus. 12:2002;291-303.
17. Young L.R. Effects of orbital space flight on vestibular reflexes and perception. Acta Astronaut. 36:1995;409-413.