Changes in the central nervous system during long-duration space flight: Implications for neuro-imaging

Advances in Space Research

Volumn 22, Issue 2, 1998, Pages 185-196

  Newberg, A B ^a   Alavi, A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; ANIMAL; BRAIN; CENTRAL NERVOUS SYSTEM; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; HUMAN; MOTION SICKNESS; NERVE CELL PLASTICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PHYSIOLOGY; RADIATION EXPOSURE; RADIOGRAPHY; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPACE FLIGHT; WEIGHTLESSNESS;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM; HUMANS; MAGNETIC RESONANCE IMAGING; NEURONAL PLASTICITY; SPACE FLIGHT; SPACE MOTION SICKNESS; TOMOGRAPHY, EMISSION-COMPUTED; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED; WEIGHTLESSNESS;

EID: 0032248973     PISSN: 02731177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0273-1177(98)80010-0     Document Type: Article

References (77)

1. 18 F-Fluorodeoxyglucose, Semin. Nucl. Med., 11, 24-31 (1981).
2. Antipov, B.P., B.I. Davydov, I.E., Ushakov, and V.P. Fedorov, The Effects of Space Flight Factors on the Central Nervous System: Structural-Functional Aspects of the Radiomodifying Effect, USSR Space Life Sci. Dig., 30, 72 (1991).
3. Antipov, V.V., B.I. Davydov, and V.S. Tikhonchuk, Radiocerebral Effects of Combined Exposure to Extreme Levels of Space Flight Factors, USSR Space Life Sci, Dig., 30, 80 (1991).
4. Becker, T., W. Retz, E. Hoffman, et al., Some Methodological Issues in Neuroradiological Research in Psychiatry. J Neural Trans., 99, 7 (1995)
5. Berry, C.A., Summary of Medical Experience in the Apollo 7 Through 11 Spaceflights, Aerosp. Med., 41,500 (1970).
6. Bonte, F.J., E.D. Ross, and H.H. Chehabi, et al., SPECT Study of Regional Cerebral Blood Flow in Alzheimer's Disease, J. Comput. Assist. Tomograph., 10, 579 (1986).
7. Brennan, K.M., M.S. Roos, and T.F. Budinger, et al., A Study of Radiation Necrosis and Edema in the Canine Brain Using Positron Emission Tomography and Magnetic Resonance Imaging, Radiation Res., 134, 43 (1993).
8. Brooks, D.J., R.P. Beaney, and M. Powell, et al., Studies on Cerebral Oxygen Metabolism, Blood Flow, and Blood Volume, in Patients with Hydrocephalus Before and After Surgical Decompression, Using Positron Emission Tomography, Brain, 109, 613 (1986).
9. Brooks, D.J., Detection of Preclinical Parkinson's Disease with PET, Neurol., 4(suppl 2), 24 (1991).
10. Brooks, D.J., V. Ibanez, and G.V. Sawle, et al., Differing Patterns of Striatal (ISF)-dopa Uptake in Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy, Ann. Neurol., 28, 547 (1990).
11. Christensen, J.M. and J.M. Talbot, eds., Research Opportunities in Human Behavior and Performance, Prepared for, The Life Sciences Division, Office of Space Science and Applications, NASA, Washington DC (1985).
12. Cleghorn, J.M., R.B. Zipursky, and S.J. List, Structural and Functional Brain Imaging in Schizophrenia, J. Psychiatry Neurosci., 16, 53 (1991).
13. Cowings, P.S. and W.B. Toscano, The Relationship of Motion Sickness Susceptibility to Learned Autonomic Control for Symptom Suppression, Aviat., Space, and Environ. Med, 53, 570 (1982).
14. Czeisler, C.A., A.J. Chiasera, and J.F. Duffy, Research On Sleep, Orcadian Rhythms and Aging: Applications to Manned Spaceflight, Experiment.Gerontol., 26, 217 (1991).
15. Damasio, H., P. Eslinger, and A.R. Damasio, et al., Quantitative Computed Tomography Analysis in the Diagnosis of Dementia, Arch. Neurol., 40: 715 (1983).
16. Davis, J.R., R.T. Jennings, B.G. Beck, et al., Treatment Efficacy of Intramuscular Promethazine for Space Motion Sickness, Aviat., Space, and Environ. Med., 64, 230 (1993).
17. Davydov, N.A., Ye.Yu. Galinka, and A.S. Ushakov, Functional Activity of the Serotonin and Histaminergic Systems in Humans Subjected to Long-Term Hypokinesia, USSR Space Life Sci. Dig., 4, 80 (1986).
18. Dmitriyev, A.S. and Tropnikova, G.K., The Effects of Low Frequency Whole-Body Vertical Vibration on the Serotonergic System of the Brain and Spinal Cord, USSR Space Life Sci. Dig., 17, 97 (1988).
19. 82 Rb Positron Emission Tomography, J. Comput. Axial Tomograph., 11, 563 (1987).
20. 18 F) Fluorodopa Positron Emission Tomographic Studies, Move. Dis., 5, 203 (1990).
21. Friston, K.J., C.D. Frith, and R.E. Passingham, et al., Motor Practice and Neurophysiological Adaptation in the Cerebellum. A Positron Emission Tomography Study, Proc. R. Soc. Lond., 248:223 (1992).
22. Frost, J.D., W.H. Shumate, J.G. Salamy, and C.R. Booher, Experiment M133, Sleep Monitoring on Skylab. In Biomedical Results from Skylab, edited by R.S. Johnston and L.F. Dietlein, (NASA SP-377). US Government Printing Office, Washington, DC (1977).
23. Fuchs, H.S., Man in Weightlessness - Physiological Problems, Clinical Aspects, Prevention, and Protection. Rivista di Med. Aeronauticae Spaziale., 44, 332 (1980).
24. Galo, M.H., C.P. Hughes, and W. Danziger, et al., Aging, Dementia, and Brain Atrophy. A Longitudinal Computed Tomography Study, A.J.N.R., 4, 699 (1983).
25. Gazenko, O. G. ed. Summaries of Reports of the 6th All-Soviet (Vol. I and II), Kaluga, USSR (1979).
26. George, A.E., L.A. Stylopolous, and M.J. deLeon, et al., Temporal Lobe CT Diagnostic Features of Alzheimer's Disease, A.J.N.R., 8, 931 (1987)[abstract].
27. Gitsov, L.G., V.G. Burneva, and L.B. Verbitskaya, Ultrastructural Changes in Neurons of the Arcuate Nucleus-Medial Eminence Complex in Rats Irradiated with Carbon Ions and Gamma-Radiation USSR Space Life Sci. Dig., 28, 92 (1990).
28. Grafton, S.T., J.C. Mazziotta, and S. Presty, et al., Functional Anatomy of Human Procedural Learning Determined With Regional Cerebral Blood Flow and PET, J. Neurosci., 12, 2542 (1992).
29. Graybiel, A., E.F. Miller, and J.L. Homick, Experiment M131, Human Vestibular Function In Biomedical Results from Skylab, edited by R.S. Johnston and L.F. Dietlein, (NASA SP-377). US Government Printing Office, Washington, DC (1977).
30. Greenberg, J.H., M. Reivich, and A. Alavi, et al., Metabolic Mapping of Functional Activity in Man With 18F-fluoro-deoxyglucose Technique, Science, 212, 678 (1981).
31. Hawkins, W.R. and J.F. Zieglschmid, Clinical Aspects of Crew Health. In Biomedical results from Apollo (NASA SP-369) edited by R.S. Johnston, L.F. Dietlein, and C.A. Berry, US Government Printing Office, Washington, DC (1975).
32. Hoffman, R.A., L.S. Pinsky, W.Z. Osborae, and J.V. Bailey, Visual Light Flash Observations on Skylab 4 In: Biomedical Results From Skylab (NASA SP-377), edited by R.S. Johnston and L.F. Dietlein, US Government Printing Office, Washington, DC, (1977).
33. Homick, J.L., R.L. Kohl, M.F. Reschke, et al., Transdermal Scopolamine in the Prevention of Motion Sickness: Evaluation of the Time Course of Efficacy, Aviat., Space, and Environ. Med.,54, 994 (1983).
34. Horowitz, J.M. and B.A. Horwitz, The Effects of Gravitational Fields On Neural Signaling in the Hippocampus. In 1988-89 NASA Space / Gravitational Biology Accomplishments, NASA Technical Memorandum 4160 edited by T. Halstead, NASA Office of Space Science and Applications, Washington, DC (1990).
35. Jagust, W.J., R.P. Friedland, and T.F. Budinger, et al., Longitudinal Studies of Regional Cerebral Metabolism in Alzheimer's Disease, Neurol., 38, 909 (1988).
36. Jamieson, D.G., J.B. Chawluck, and A Alavi, et al., The Effect of Disease Severity on Local Cerebral Glucose Metabolism in Alzheimer's Disease, J. Cerebr. Blood Flow Metab., 7:S410 (1987).
37. Johnson, C.C. and R.D. Arno, eds., Life Science Research Objectives and Representative Experiments for the Space Station. NASA Technical Memorandum 89445, Ames Research Center, CA (1989).
38. Johnston, R.S. and L.F. Dietlein, eds., Biomedical Results from Skylab, Scientific and Technical Information Office, NASA, Washington, DC (1977).
39. 56 Fe Heavy-Particle Irradiation: Implications for Manned Space Flight, Radiat. Res., 130, 88 (1992).
40. Kovalev, V.Yu. and A.E. Enes, Investigation of the Postflight Concentration of L-cystathionine in Various Areas of the Brains of Rats in an Experiment on the Cosmos-1129 Biosatellite. USSR Space Life Sci. Dig., 15, 90 (1988).
41. 18 F Fluorodeoxyglucose Method, J. Cerebr. Blood Flow Metab., 7, S411 (1987).
42. Kumar, A., M.B. Schapiro, and C. Grady, et al., High-resolution PET studies in Alzheimer's disease, Neuropsychopharmacol, 4, 35 (1991).
43. Kunz, U., P. Heintz, C. Ehrenheim, et al., MRI as the Primary Diagnostic Instrument in Normal Pressure Hydrocephalus? Psych. Res., 29, 287 (1989).
44. Kushner, M.J., A. Rosenquist, and A. Alavi, et al., Cerebral Metabolism and Patterned Visual Stimulation. A Positron Emission Tomographic Study of the Human Visual Cortex, Neurol., 38, 89 (1988).
45. Lackner, J.R. and A. Graybiel, Variations in Gravitoinertial Force Level Affect the Gain of the Vestibulo-Ocular Reflex: Implications for the Etiology of Space Motion Sickness, Aviat., Space, and Environ. Med., 52, 154 (1981).
46. Leenders, K.L., E.P. Salmon, and P. Tyrrell, et al., The Nigrostriatal Dopaminergic System Assessed In Vivo By Positron Emission Tomography In Healthy Volunteer Subjects and Patients With Parkinson's Disease, Arch. Neurol., 47, 1290 (1990).
47. Lo, E.H., K.A. Frankel, and R.L. Delapaz, et al., Cerebrovascular and Metabolic Perturbations in Delayed Heavy Charged Particle Radiation Injury, Brain Res., 504, 168 (1989).
48. Martin, W.R.W., A. Stoessel, et al., Positron Emission Tomography in Parkinson's Disease, Glucose and Dopa Metabolism, Adv. Neurol., 45:95 (1986).
49. Matsnev, E.I., I.K. Yakovleva, and V.N. Tarasov, et al. Space Motion Sickness: Phenomenology, Countermeasures, and Mechanisms, Aviat., Space, and Environ. Med.,54, 312 (1983).
50. Miller, J.D., B.A. McMillen, D.M. Murakami, and M.M. McConnaughey, Effects of Weightlessness on Neurotransmitter Receptors in Selected Brain Areas, Physiologist, 28,S203 (1985).
51. Miller, J.D., B.A. McMillen, M.M. McConnaughey, et al., Effects of Microgravity on Brain Neurotransmitter Receptors, Euro. J. Pharm., 161, 165 (1989).
52. Morey-Holton, E. and M. Tischler, eds., NASA Workshop on Biological Adaptation: NASA Technical Memorandum 89468, Ames Research Center, California (1988).
53. Nagel, J.S., M. Ichise, and B.L. Holman, The Scintigraphic Evaluation of Huntington's Disease and Other Movement Disorders Using Single Photon Emission Computed Tomography Perfusion Brain Scans, Semin. Nucl. Med., 21, 11 (1991).
54. NASA Life Sciences Strategic Planning Study Committee, Exploring the Living Universe: A Strategy for Space Life Sciences, NASA, Washington DC (1988).
55. Newberg, A.B. and A. Alavi, Role of Positron Emission Tomography in the Investigation of Neuropsychiatric Disorders, in Diagnostic Nuclear Medicine, Third Edition, edited by M.P. Sandler, R.E. Coleman, F.J.T. Wackers, J.A. Patton, A. Gottschalk, and P.B. Hoffer, Williams & Wilkins, Baltimore, Volume 2, pp.1099 (1996).
56. Newberg, A.B., Changes in the Central Nervous System and their Clinical Correlates During Long-Term Spaceflight, Aviat. Space Environ. Med. , 65,562 (1994).
57. Nicogossian, A.E., Space Physiology and Medicine, Lea & Febiger, Philadelphia 1994.
58. Ogawa, T., K. Uemura, and F. Shishido, et al., Changes of Cerebral Blood Flow and Oxygen and Glucose Metabolism Following Radiochemotherapy of Gliomas, A PET Study, J. Comput. Assist Tomograph 12, 290 (1988).
59. Pfefferbaum, A., E.V. Sullivan, and T.L. Jernigan, et al., A quantitative Analysis of CT and Cognitive Measures in Normal Aging and Alzheimer's Disease, Psych. Res. Neuroimaging, 35, 115 (1990).
60. Phelps, M.E. and J.C. Mazziotta, Positron Emission Tomography: Human Brain Function and Biochemistry, Science, 228, 799 (1985).
61. Rabin, B.M., W.A. Hunt, and J.A. Joseph, An Assessment of the Behavioral Toxicity of High-Energy Iron Particles Compared to Other Qualities of Radiation, Radiation Res., 119, 113 (1989).
62. Reschke, M.F. and D.E. Parker, Effects of Prolonged Weightlessness on Self-Motion Perception and Eye Movements Evoked by Roll and Pitch, Aviat. Space and Environ. Med., 58, Sect. 11 (1987).
63. Rougemont, D., J.C. Baron, and P. Collard, et al., Local Cerebral Glucose Utilisation in Treated and Uuntreated Patients with Parkinson's Disease, J. Neurol. Neurosurg. Psych., 47, 824 (1984).
64. Santy, P.A., H. Kapanka, J.R. Davis, and D.F. Stewart, Analysis of Sleep on Shuttle Missions, Aviat. Space Environ. Med, 59, 1094 (1988).
65. Sasaki, E.H., Effects of Transient Weightlessness on Binocular Depth Perception, Aerosp. Med.,36, 343-344 (1965).
66. Sawle, G.V., S.J. Wroe, and A.J. Lees, et al., The Identification of Presymptomatic Parkinsonism, Clinical and [18F] Dopa Positron Emission Tomography Studies in an Irish Kindred, Ann. Neurol, 32, 609 (1992).
67. Sedvall, G., The Current Status of PET Scanning With Respect to Schizophrenia, Neuropsychopharmacol., 7, 41 (1992).
68. Simonov, P. V. and M. V. Frolov, Utilization of Human Voice for Estimation of Man's Emotional Stress and State of Attention, Aerosp. Med.,44, 256 (1973).
69. Smith, F.W., J.A. Besson, and H.G. Gemmell, et al., Tecnnetium-99m HMPAO Imaging in Patients Wwith Basal Ganglia Disease, Brit. J. Radiol., 61, 914 (1988).
70. Tanna, N.K., M.I. Kohn, and D.N. Horwich, et al., Analysis of Brain and Cerebrospinal Fluid Volumes With MR Imaging: Impact on PET Data, Correction for Atrophy, Radiol., 178, 123 (1991).
71. Tedeschi, E., S.G. Hasselbalch, and G. Waldemar, et al., Heterogeneous Cerebral Glucose Metabolism in Normal Pressure Hydrocephalus, J. of Neurol., Neurosurg., and Psych., 59, 608 (1995).
72. Thornton, W.E. and J.A. Rummel, Muscular Deconditioning and its Prevention in Space Flight, In Biomedical Results from Skylab, edited by R.S. Johnston and L.F. Dietlein, (NASA SP-377). US Government Printing Office, Washington, DC (1977).
73. Valk, P.E., T.F. Budinger, and V.A. Levin, et al., Positron Emission Tomography of Malignant Cerebral Tumors After Interstitial Brachytherapy, Demonstration of Metabolic Activity and Correlation With Clinical Outcome, J. Neurosurg., 69:830 (1988).
74. Waldemar, G., J.F. Schmidt, and F. Delecluse, et al., High Resolution SPECT With [99mTc]-d, 1-HMPAO in Normal Pressure Hydrocephalus Before and After Shunt Operation, J. of Neurol., Neurosurg., and Psych., 56, 655 (1993).
75. Watt, D.G.D., K.E. Monet, R.L. Bondar, and R.B. Thirsk, Canadian Medical Experiments on Shuttle Flight 41-G, Canadian Aeronautics Space J., 31,215 (1985).
76. Young, L.R., C.M. Oman, D.G.D. Watt, and K.E. Money, MIT/Canadian Vestibular Experiments on the Spacelab-1 Mission: 1. Sensory Adaptation to Weightlessness and Readaptation to One-g: An Overview, Experimental Brain Research, 64, 291 (1986).
77. Yuganov, Ye.M. and V.I. Kopanev, Physiology of the Sensory Sphere Under Spaceflight Conditions, In Foundations of Space Biology and Median, edited by M. Calvin and O.G. Gazenko, pp. 571-598, NASA Scientific and Technical Information Office, Washington, DC (1975).