Serum from patients with acute coronary syndromes displays a proapoptotic effect on human endothelial cells: A possible link to pan-coronary syndromes

Circulation

Volumn 107, Issue 2, 2003, Pages 264-270

  Valgimigli, Marco ^a,b   Agnoletti, Laura ^b   Curello, Salvatore ^b   Comini, Laura ^b   Francolini, Gloria ^b   Mastrorilli, Francesca ^a   Merli, Elisa ^a   Pirani, Roberto ^a   Guardigli, Gabriele ^a   Grigolato, Pier Giovanni ^c   Ferrari, Roberto ^a,b  

^a UNIVERSITY OF FERRARA   (Italy)

^b IRCCS   (Italy)

^c Spedali Civili ^*  (Italy)

Author keywords

Apoptosis; Endothelium; Inflammation; Interleukins; Plaque

Indexed keywords

ANTIOXIDANT; FAS ANTIGEN; INTERLEUKIN 6 ANTIBODY; PROTEIN BAX; PROTEIN BCL 2; TROLOX C; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ADULT; AGED; ANGINA PECTORIS; ANGIOGRAPHY; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; BLOOD ANALYSIS; CIRCULATION; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DATA ANALYSIS; ENDOTHELIUM CELL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOBLOTTING; INCUBATION TIME; MALE; NORMAL HUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SERUM; STATISTICAL SIGNIFICANCE; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ACUTE DISEASE; AGED; ANGINA PECTORIS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD95; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOOD PROTEINS; CELLS, CULTURED; CHROMANS; CORONARY ANGIOGRAPHY; CORONARY DISEASE; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-6; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; SIALOGLYCOPROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037458123     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000045665.57256.86     Document Type: Article

References (34)

1. Goldstein JA, Demetriu D, Grines CL, et al. Multiple complex coronary plaques in patients with acute myocardial infarction. N Engl J Med. 2000;343:915-922.
2. Asakura M, Ueda Y, Yamaguchi O, et al. Extensive development of vulnerable plaques as a pan-coronary process in patients with myocardial infarction: an angioscopic study. J Am Coll Cardiol. 2001;37:1284-1288.
3. Guazzi MD, Bussotti M, Grancini L, et al. Evidence of multifocal disease in patients with acute myocardial infarction. Circulation. 1997;96:1145-1151.
4. Gilpin EA, Koziol JA, Madsen EB, et al. Periods of differing mortality distribution during the first year after acute myocardial infarction. Am J Cardiol. 1983;52:240-244.
5. Isner JM, Kearney M, Bortman S, et al. Apoptosis in human atherosclerosis and restenosis. Circulation. 1995;91:2703-2711.
6. Knockx MM. Apoptosis in the atherosclerotic plaque: quantitative and qualitative aspects. Arterioscler Thromb Vasc Biol. 1998;18:1519-1522.
7. Han DK, Haudenschild CC, Hong MK, et al. Evidence for apoptosis in human atherogenesis and in a rat vascular injury model. Am J Pathol. 1995;147:267-277.
8. Harada K, Chen Z, Ishibashi S, et al. Apoptotic cell death in atherosclerotic plaques of hyperlipidemic knockout mice. Atherosclerosis. 1997;135:235-239.
9. Geng YJ, Libby P. Evidence for apoptosis in advanced human atheroma: colocalization with interleukin 1b converting enzyme. Am J Pathol. 1995;147:251-266.
10. Farb A, Burke AP, Tang AL, et al. Coronary plaque erosion without rupture into a lipid core: a frequent cause of coronary thrombus in sudden coronary death. Circulation. 1996;93:1354-1363.
11. Bombeli T, Karsan A, Tait JF, et al. Apoptotic vascular endothelial cells become procoagulant. Blood. 1997;89:2429-2442.
12. Bombeli T, Schwartz BR, Harlan JM. Endothelial cells undergoing apoptosis become proadhesive for nonactivated platelets. Blood. 1999;93:3831-3838.
13. Mallat Z, Hugel B, Ohan J, et al. Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity. Circulation. 1999;99:348-353.
14. Ambrose JA, Winters SL, Stern A, et al. Angiographic morphology and the pathogenesis of unstable angina pectoris. J Am Coll Cardiol. 1985;5:609-616.
15. Rehr R, Disciascio G, Vetrovec G, et al. Angiographic morphology of coronary artery stenoses in prolonged rest pain: evidence of intracoronary thrombosis. J Am Coll Cardiol. 1989;14:1429-1437.
16. Qiao JH, Fishbein MC. The severity of coronary atherosclerosis at site of plaques rupture with occlusive thrombosis. J Am Coll Cardiol. 1991;17:1138-1142.
17. Ferrari R, Bachetti T, Confortini R, et al. Tumor necrosis factor soluble receptors in patients with various degree of congestive heart failure. Circulation. 1995;92:1479-1486.
18. Choy JC, Granvile DJ, Hunt DW, et al. Mildly oxidized low density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells. FASEB J. 2000;14:1996-2007.
19. Heermeier K, Leicht W, Palmetshofer, et al. Oxidized LDL suppresses NF-κB and overcomes protection from apoptosis in activated endothelial cells. J Am Soc Nephrol. 2001;12:456-463.
20. Jaffe EA, Nachman L, Becker CG, et al. Culture of human endothelial cells derived from umbilical veins. J Clin Invest. 1973;52:2745-2756.
21. Nicoletti I, Migliorati G, Pagliacci MC, et al. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods. 1991;139:271-279.
22. Agnoletti L, Curello S, Bachetti T, et al. Serum from patients with severe heart failure downregulates eNOS and is proapoptotic: role of tumor necrosis factor-α. Circulation. 1999;100:1983-1991.
23. Kataoka H, Hume N, Miyamoto S, et al. Oxidized LDL modulates Bax/Bcl-2 through the lectinlike Ox-LDL receptor-1 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2001;21:955-960.
24. Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation. 2001;104:365-372.
25. Lutgens E, Daemen MJ, Kockx M, et al. Atherosclerosis in APOE*3-Leiden transgenic mice: from proliferative to atheromatous stage. Circulation. 1999;99:276-283.
26. Witzum JL. The oxidation hypothesis of atherosclerosis. Lancet. 1994;344:793-795.
27. Yim MB, Yim HS, Lee C, et al. Protein glycation: creation of catalytic sites for free radical generation. Ann N Y Acad Sci. 2001;928:48-53.
28. Thomas MJ, Chen Q, Sorci-Thomas MG, et al. Isoprostane levels in lipids extracted from atherosclerotic arteries of nonhuman primates. Free Radic Biol Med. 2001;30:1337-1346.
29. Carmody RJ, Cotter TG, Signalling apoptosis: a radical approach. Redox Rep. 2001;6:77-90.
30. Yokoyama I, Negita M, Hayakawa A, et al. Cytosolic calcium dynamics and free radical-induced apoptosis of the endothelial cells. Transplant Proc. 1999;31:808-809.
31. Jacob AK, Hotchkiss RS, DeMeester SL, et al. Endothelial cell apoptosis is accelerated by inorganic iron and heat via an oxygen radical dependent mechanism. Surgery. 1997;122:243-253.
32. Cipollone F, Cianattoni G, Patrignani P, et al. Oxidant stress and aspirininsensitive thromboxane biosynthesis in severe unstable angina. Circulation. 2000;102:1007-1013.
33. Nakajima T, Schulte S, Warrington KJ, et al. T-cell-mediated lysis of endothelial cells in acute coronary syndromes. Circulation. 2002;105:570-575.
34. Buffon A, Biasucci LM, Liuzzo G, et al. Widespread inflammation in unstable angina. N Engl J Med. 2002;347:5-12.