Process for preparing Ezetimibe intermediate by an acid enhanced chemo- and enantioselective CBS catalyzed ketone reduction

Tetrahedron Letters

Volumn 44, Issue 4, 2003, Pages 801-804

  Fu, Xiaoyong ^a   McAllister, Timothy L ^a   Thiruvengadam, T K ^a   Tann, Chou Hong ^a,b   Su, Dan ^a,c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Rhodia ChiRex Boston   (United States)

^c Steris Laboratories Inc   (United States)

Author keywords

Asymmetric ketone reduction; Ezetimibe; R MeCBS

Indexed keywords

ACID; ALCOHOL; ANTILIPEMIC AGENT; BORANE DERIVATIVE; CARBONYL DERIVATIVE; CHEMICAL COMPOUND; EZETIMIBE; KETONE DERIVATIVE; REDUCING AGENT; SCAVENGER; SODIUM BOROHYDRIDE; TETRAHYDROFURAN DERIVATIVE; WATER;

ADDITION REACTION; ARTICLE; CATALYSIS; ENANTIOSELECTIVITY; PARAMETER; REDUCTION; SYNTHESIS; TEMPERATURE; WATER CONTENT;

EID: 0037454990     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)02700-4     Document Type: Article

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