DNA adducts, strand breaks and micronuclei in mice exposed to styrene by inhalation

Chemico-Biological Interactions

Volumn 137, Issue 3, 2001, Pages 213-227

  Vodicka, Pavel ^a   Koskinen, Mikko ^b   Vodicková, Ludmila ^c   Štetina, Rudolf ^d   Šmerák, Petr ^e   Bárta, Ivo ^e   Hemminki, Kari ^b  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

^d DEPARTMENT OF TOXICOLOGY   (Czech Republic)

^e CHARLES UNIVERSITY   (Czech Republic)

Author keywords

DNA adducts; DNA strand breaks; Micronuclei; Styrene; Styrene 7,8 oxide

Indexed keywords

1 STYRENE OXIDE ADENINE DERIVATIVE; 7 STYRENE OXIDE GUANINE DERIVATIVE; ADENINE DERIVATIVE; CLASTOGEN; DNA; DNA FRAGMENT; ENDONUCLEASE; GUANINE DERIVATIVE; NUCLEOTIDE; STYRENE; STYRENE OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BONE MARROW CELL; CELL COUNT; CELL PROLIFERATION; CHROMATID; COMET ASSAY; CONTROLLED STUDY; DNA ADDUCT; DNA STRAND BREAKAGE; EXPOSURE; GENOTOXICITY; LUNG PARENCHYMA; MALE; MICRONUCLEUS; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PERIPHERAL LYMPHOCYTE;

ADMINISTRATION, INHALATION; ANIMALS; BONE MARROW CELLS; COMET ASSAY; DNA; DNA ADDUCTS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXY COMPOUNDS; ERYTHROCYTES; HEPATOCYTES; LUNG; LYMPHOCYTES; MALE; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MUTAGENS; STYRENE;

EID: 0035964974     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(01)00253-8     Document Type: Article

References (37)

1. Styrene
2. Review of the toxicology of styrene
3. Evaluation of the metabolism and hepatotoxicity of styrene in F344 rats, B6C3F1 mice, and CD-1 mice following single and repeated inhalation exposures
4. Styrene-7,8-oxide
5. Disposition of [Ring-U-14C]styrene in rats and mice exposed by recirculating nose-only inhalation
6. Review of the metabolic fate of styrene
7. Specific DNA adducts induced by some mono-substituted epoxides in vitro and in vivo
8. DNA adducts, mutations and cancer
9. Styrene oxide-induced 2′-deoxycytidine adducts: Implications for the mutagenicity of styrene oxide
10. Adenine N3 is a main alkylation site of styrene oxide in double-stranded DNA
11. 32P-postlabelling/HPLC analysis of various styrene-induced DNA adducts in mice
12. Adduct formation on DNA and haemoglobin in mice intraperitoneally administered with styrene
13. 6-substituted adenine and 3-substituted cytosine/uracil: Formation and persistence in vitro and in vivo
14. 6-adenine adducts of epoxybutanediol in vivo after 1,3-butadiene exposure
15. Human DNA adducts of 1,3-butadiene, an important environmental carcinogen
16. A re-evaluation of the cytogenetic effects of styrene
17. Is human exposure to styrene a cause of cytogenetic damage? A re-analysis of the available evidence
18. Cytotoxic and genotoxic effects of styrene-7,8-oxide in neuroadrenergic Pc 12 cells
19. Styrene oxide-induced HPRT mutations, DNA adducts and DNA strand breaks in cultured human lymphocytes
20. 32P-postlabeling in DNA and human embryonal lung fibroblasts (HEL)
21. Detection of styrene and styrene oxide-induced DNA damage in various organs of mice using the comet assay
22. Single-strand breaks, chromosome aberrations, sister-chromatid exchanges, and micronuclei in blood lymphocytes of workers exposed to styrene during the production of reinforced plastics
23. Exposure dependent increase in DNA single strand breaks in leucocytes from workers exposed to low concentrations of styrene
24. An evaluation of styrene genotoxicity using several biomarkers in a 3-year follow-up study of hand-lamination workers
25. Biomonitoring of occupational exposure to styrene in a plastics lamination plant
26. 6-guanine DNA adducts, DNA strand breaks and mutant frequencies in the hypoxanthine guanine phosphoribosyltransferase gene in T-lymphocytes
27. Relative subnarcotic potency of solvents predicted by partition coefficients
28. Oxidative damage to DNA: Do we have a reliable biomarker?
29. Guidelines for the conduct of micronucleus assays in mammalian bone marrow erythrocytes
30. The micronucleus test
31. Mutagenic effects of some mycotoxins
32. 14C-styrene by nose-only inhalation
33. Catalytic triad of microsomal epoxide hydrolase: Replacement of Glu404 with Asp leads to a strongly increased turnover rate
34. Cytogenetic studies of rodents exposed to styrene by inhalation
35. Cytogenetic studies of mice exposed to styrene by inhalation
36. Termination of DNA synthesis in vitro at apurinic sites but not at ethyl adducts on the template