Synthesis and benzodiazepine receptor affinity of pyrazolo[1,5-a]pyrimidine derivatives. 3. New 6-(3-thienyl) series as α1 selective ligands

Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2003, Pages 310-313

  Selleri, Silvia ^a   Bruni, Fabrizio ^a   Costagli, Camilla ^a   Costanzo, Annarella ^a   Guerrini, Gabriella ^a   Ciciani, Giovanna ^a   Gratteri, Paola ^a   Bonaccini, Claudia ^a   Malmberg Aiello, Petra ^a   Besnard, François ^b   Renard, Stephane ^b   Costa, Barbara ^c   Martini, Claudia ^c  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Synthélabo ^*  (France)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; BENZODIAZEPINE RECEPTOR; DIAZEPAM; LIGAND; PYRAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; RECEPTOR SUBTYPE; RECOMBINANT RECEPTOR; ZOLPIDEM;

ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG EFFECT; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR MODEL; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; BINDING, COMPETITIVE; BRAIN; CATTLE; LIGANDS; MODELS, MOLECULAR; MUSCLE RELAXANTS, CENTRAL; PYRIMIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, GABA-A;

EID: 0037448347     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020999w     Document Type: Article

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