Beyond type 2 diabetes: The need for a clinically useful way to identify insulin resistance

American Journal of Medicine

Volumn 114, Issue 6, 2003, Pages 501-502

  McLaughlin, Tracey L ^a   Reaven, Gerald M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROINSULIN; TRIACYLGLYCEROL;

AGE DISTRIBUTION; ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL PRACTICE; CORONARY RISK; DIABETIC OBESITY; DIAGNOSTIC TEST; DISEASE ASSOCIATION; DYNAMIC EXERCISE; DYSLIPIDEMIA; FAMILY HISTORY; FATTY LIVER; FITNESS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HEALTH CARE COST; HIGH RISK PATIENT; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN DEFICIENCY; INSULIN RESISTANCE; INSULIN SENSITIVITY; ISCHEMIC HEART DISEASE; LIFESTYLE; MEDICAL RESEARCH; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; OVARY POLYCYSTIC DISEASE; PATHOPHYSIOLOGY; PATIENT EDUCATION; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; TRIACYLGLYCEROL BLOOD LEVEL; UNITED STATES; WEIGHT REDUCTION;

EID: 0037447531     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9343(03)00122-0     Document Type: Editorial

References (12)

1. Killilea T. Long-term consequences of type 2 diabetes mellitus economic impact on society and managed care . Am J Manag Care. 16:(suppl):2002;S441-S449.
2. Tuomilehto J., Lindstrom J., Eriksson J.G., et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 344:2001;1343-1350.
3. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 346:2002;393-403.
4. Zavaroni I., Bonini L., Gasparini P., et al. Hyperinsulinemia in a normal population as a predictor of non-insulin-dependent diabetes mellitus, hypertension, and coronary heart disease the Barilla factory revisited . Metabolism. 48:1999;989-994.
5. Bogardus C., Lillioja S., Mott D.M., Hollenbeck C., Reaven G.M. Relationship between degree of obesity and in vivo insulin action in man. Am J Physiol. 11:1985;E286-E291.
6. Hollenbeck C., Reaven G.M. Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. J Clin Endocrinol Metab. 64:1987;1169-1173.
7. Pradhan A.D., Manson J.E., Meigs J.B., et al. Insulin, proinsulin, proinsulin:insulin ratio, and the risk of developing type 2 diabetes mellitus in women. Am J Med. 114:2003;438-444.
8. Hanley A., D'Agostino R., Wagenknecht L.E., et al. Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the Insulin Resistance Atherosclerosis Study. Diabetes. 51:2002;1263-1270.
9. Yip J., Facchini F.S., Reaven G.M. Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease. J Clin Endocrinol Metab. 83:1998;2773-2776.
10. Isomaa B., Almgren P., Tuomi T., et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 24:2001;683-689.
11. Lakka H.M., Laaksonen D.E., Lakka T.A., et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 288:2002;2709-2716.
12. Despres J.P., Lamarche B., Mauriege P., et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med. 334:1996;952-957.