Novel isoforms of dlg are fundamental for neuronal development in Drosophila

Journal of Neuroscience

Volumn 23, Issue 6, 2003, Pages 2093-2101

  Mendoza, Carolina ^a   Olguín, Patricio ^a   Lafferte, Gabriela ^a   Thomas, Ulrich ^b   Ebitsch, Susanne ^b   Gundelfinger, Eckart D ^b   Kukuljan, Manuel ^a   Sierralta, Jimena ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

Author keywords

Alternative transcripts; dlg; Drosophila; dsRNA; Neuronal differentiation; SAP97; Scaffold proteins

Indexed keywords

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CELL DIFFERENTIATION; DROSOPHILA; EMBRYO DEVELOPMENT; EPITHELIUM CELL; NERVE GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR GROWTH;

EID: 0037444435     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-06-02093.2003     Document Type: Article

References (40)

1. Bellaiche Y, Radovic A, Woods DF, Hough CD, Parmentier ML, O'Kane CJ, Bryant PJ, Schweisguth F (2001) The partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila. Cell 106:355-366.
2. Bossinger O, Klebes A, Segbert C, Theres C, Knust E (2001) Zonula adherens formation in Caenorhabditis elegans requires dlg-1, the homologue of the Drosophila gene discs large. Dev Biol 230:29-42.
3. Budnik V, Koh Y-H, Guan B, Haugh C, Woods D, Gorczyca M (1996) Regulation of synapse structure and function by the Drosophila tumor suppressor gene, dlg. Neuron 17:627-640.
4. Chetkovich DM, Bunn RC, Kuo S-H, Kawasaki Y, Kohwi M, Bredt DS (2002) Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms. J Neurosci 22:6415-6425.
5. Doerks T, Bork P, Kamberov E, Makarova O, Muecke S, Margolis B (2000) L27, a novel heterodimerization domain in receptor targeting proteins Lin-2 and Lin-7. Trends Biochem Sci 25:317-318.
6. Ellis MC, O'Neill EM, Rubin GM (1993) Expression of Drosophila glass protein and evidence for negative regulation of its activity in non-neuronal cells by another DNA binding protein. Development 119:855-865.
7. Firestein BL, Rongo C (2001) DLG-1 Is a MAGUK similar to SAP97 and is required for adherens junction formation. Mol Biol Cell 12:3465-3475.
8. Garner CC, Nash J, Huganir RL (2000) PDZ domains in synapse assembly and signalling. Trends Cell Biol 10:274-280.
9. Grenningloh G, Rehm J, Goodman CS (1991) Genetic analysis of growth cone guidance in Drosophila: Fasciclin II functions as a neuronal recognition molecule. Cell 67:45-57.
10. Hough CD, Woods DF, Park S, Bryant PJ (1997) Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs large. Genes Dev 11:3242-3253.
11. Hummel T, Krukkert K, Roos J, Davis G, Klambt C (2000) Drosophila Futsch/22C10 is a MAP1B-Iike protein required for dendritic and axonal development. Neuron 26:357-370.
12. Kennerdell JR, Carthew RW (1998) Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell 95:1017-1026.
13. Koh YH, Popova E, Thomas U, Griffith LC, Budnik V (1999) Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation. Cell 98:353-363.
14. Lahey T, Gorczyca M, Jia X, Budnik V (1994) The Drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure. Neuron 13:823-835.
15. Lee S, Fan S, Makarova O, Straight S, Margolis B (2002) A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia. Mol Cell Biol 22:1778-1791.
16. Lue RA, Marfatia SM, Branton D, Chishti AH (1994) Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. Proc Natl Acad Sci USA 91:9818-9822.
17. Marfatia SM, Byron O, Campbell G, Liu SC, Chishti AH (2000) Human homologue of the Drosophila discs large tumor suppressor protein forms an oligomer in solution. Identification of the self-association site. J Biol Chem 275:13759-13770.
18. McLaughlin M, Hale R, Ellston D, Gaudet S, Lue RA, Viel A (2002) The distribution and function of alternatively spliced insertions in hDlg. J Biol Chem 277:6406-6412.
19. Mathew D, Gramates LS, Packard M, Thomas U, Bilder D, Perrimon N, Gorczycal M, Budnik V (2002) Recruitment of Scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Curr Biol 12:531-539.
20. Müller BM, Kismet U, Veh RW, Cases-Langhoff C, Becker B, Gundelfinger ED, Garner CC (1995) Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. J Neurosci 15:2354-2366.
21. Myers EW, Sutton GG, Delcher AL, Dew IM, Fasulo DP, Flanigan MJ, Kravitz SA, Mobarry CM, Reinert KH, Remington KA, Anson EL, Bolanos RA, Chou HH, Jordan CM, Halpern AL, Lonardi S, Beasley EM, Brandon RC, Chen L, Dunn PJ, et al. (2000) A whole-genome assembly of Drosophila. Science 287:2196-2204.
22. Ohshiro T, Yagami T, Zhang C, Matsuzaki F (2000) Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature 408:593-596.
23. Peng C, Manning L, Albertson R, Doe CQ (2000) The tumour suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature 408:596-600.
24. Perrimon N (1988) The maternal effect of lethal(1)discs-large-1: a recessive oncogen of Drosophila melanogaster. Dev Biol 127:392-407.
25. Rechsteiner M, Rogers SW (1996) PEST sequences and regulation byproteolysis. Trends Biochem Sci 21:267-271.
26. Robinow S, White K (1991) Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development. J Neurobiol 22:443-461.
27. +-channels in the central nervous system and retina of Drosophila. J Neurochem 82:1490-1501.
28. Seeger M, Tear G, Ferres-Marco D, Goodman CS (1993) Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron 10:409-415.
29. Tejedor FJ, Bokhari A, Rogero O, Gorczyca M, Zhang J, Kim E, Sheng M, Budnik V (1997) Essential role for dlg in synaptic clustering of shaker K channels in vivo. J Neurosci 17:152-159.
30. Tepass U, Tanentzapf G, Ward R, Fehon R (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu Rev Genet 35:747-784.
31. Thomas U, Kim E, Kuhlendahl S, Koh YH, Gundelfinger ED, Sheng M, Garner CC, Budnik V (1997a) Synaptic clustering of the cell adhesion molecule fasciclin II by discs-large and its role in the regulation of presynaptic structure. Neuron 19:787-799.
32. Thomas U, Phannavong B, Müller B, Garner CC, Gundelfinger ED (1997b) Functional expression of rat synapse-associated proteins SAP97 and SAP102 in Drosophila dlg-1 mutants: effects on tumor suppression and synaptic bouton structure. Mech Dev 62:161-174.
33. Thomas U, Ebitsch S, Gorczyca M, Koh YH, Hough CD, Woods DF, Gundelfinger ED, Budnik V (2000) Synaptic targeting and localization of discs-large is a stepwise process controlled by different domains of the protein. Curr Biol 10:1108-1117.
34. Woods DF, Bryant PJ (1989) Molecular cloning of the lethal(1) discs large-1 oncogene of Drosophila. Dev Biol 134:222-235.
35. Woods DF, Bryant PJ (1991) The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell 66:451-464.
36. Woods DF, Hough C, Peel D, Callaini G, Bryant PJ (1996) Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia. J Cell Biol 134:1469-1482.
37. Wu H, Reuver SM, Kuhlendahl S, Chung WJ, Garner CC (1998) Subcellular targeting and cytoskeletal attachment of SAP97 to the epithelial lateral membrane. J Cell Sci 111:2365-2376.
38. Wu H, Reissner C, Kuhlendahl S, Coblentz B, Reuver S, Kindler S, Gundelfinger ED, Garner CC (2000) Intramolecular interactions regulate SAP97 binding to GKAP. EMBO J 19:5740-5741.
39. Zipursky SL, Venkatesh TR, Teplow DB, Benzer S (1984) Neuronal development in the Drosophila retina: monoclonal antibodies as molecular probes. Cell 36:15-26.
40. Zito K, Fetter RD, Goodman CS, Isacoff EY (1997) Synaptic clustering of Fascilin II and Shaker: essential targeting sequences and role of Dlg. Neuron 19:1007-1016.