Symptom severity patterns in experimental common colds and their usefulness in timing onset of illness in natural colds

Clinical Infectious Diseases

Volumn 36, Issue 6, 2003, Pages 714-723

  Gwaltney Jr , Jack M ^a   Hendley, J Owen ^a   Patrie, James T ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO;

ARTICLE; CHILL; COMMON COLD; COUGHING; DISEASE DURATION; DISEASE SEVERITY; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALAISE; NOSE OBSTRUCTION; PRIORITY JOURNAL; RHINORRHEA; RHINOVIRUS; SNEEZING; SORE THROAT; SYMPTOMATOLOGY; VIRUS INFECTION;

COMMON COLD; DISEASE PROGRESSION; HUMANS; REACTION TIME;

EID: 0037443952     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/367844     Document Type: Article

References (22)

1. Gwaltney JM Jr, Buier RM, Rogers JL. The influence of signal variation, bias, noise, and effect size on statistical significance in treatment studies of the common cold. Antiviral Res 1996; 29:287-95.
2. Gwaltney JM Jr. The use of experimentally infected volunteers in research on the common cold. In: Lenfiant C, Skoner DP, eds. Asthma and respiratory infections. New York: Marcel-Dekker, 2001:103-27.
3. Sperber SJ, Hendley JO, Hayden FG, Riker DK, Sorrentino JV, Gwaltney JM Jr. Effects of naproxen in experimental rhinovirus colds. Ann Intern Med 1992; 117:37-41.
4. Gwaltney JM Jr, Park J, Paul RA, Edelman DA, O'Connor RR, Turner RB. A randomized controlled trial of clemastine fumarate in experimental rhinovirus colds. Clin Infect Dis 1996; 22:656-62, 1996.
5. Gwaltney JM Jr, Druce HM. Efficacy of brompheniramine maleate for the treatment of rhinovirus colds. Clin Infect Dis 1997; 25:1188-94.
6. Turner RB, Wecker MT, Pohl G, et al. Efficacy of tremacamra, a soluble adhesion molecule 1, for experimental rhinovirus infection: a randomized clinical trial. JAMA 1999; 281:1797-804.
7. Gwaltney JM Jr, Winther B, Patrie JT, Hendley JO. Combined antiviral-antimediator treatment for the common cold. J Infect Dis 2002; 186:147-54.
8. Gwaltney JM Jr, Hendley JO, Simon G, Jordan WS Jr. Rhinovirus infections in an industrial population. II. Characteristics of illness and antibody response. JAMA 1967; 202:494-500.
9. Gwaltney JM Jr, Hendley JO, Winther B. A randomized, double-blind, placebo controlled study to assess the effectiveness of intranasally applied interferon alfa-2b combined with oral ibuprofen and brompheniramine maleate on symptom reduction and safety in natural colds in normal adults. Report to US Food and Drug Administration (FDA) IND 7631, Protocol V-203-99. Rockville, MD: FDA, 2000.
10. Gwaltney JM Jr, Hendley JO, Winther B. A randomized, double-blind, placebo controlled study to assess the effectiveness of intranasally applied interferon alfa-2b combined with oral ibuprofen and chlorpheniramine maleate on symptom reduction and safety in natural normal adults with natural colds. Report to US Food and Drug Administraion (FD) IND 7631, Protocol V-205-00. Rockville, MD: FDA, 2001.
11. Gwaltney JM Jr, Hendley JO. Respiratory transmission. In: Thomas JC, Weber DJ, eds. Epidemiologic methods for the study of infectious diseases. New York: Oxford University Press, 2001:213-27.
12. Liang K-Y, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika 1986; 73:13-22.
13. McCullagh P, Nelder JA. Generalized linear models. 2nd ed. London: Chapman and Hall, 1989.
14. White H. Maximum likelihood estimation of misspecified models. Econometrica 1982; 50:1-25.
15. Collett D. Modeling survival data in medical research. London: Chapman and Hall, 1995. Rosner B. Fundamentals of biostatistics. 5th ed. Pacific Grove, CA: Duxbury Press, 2000.
16. Casella G, Berger RL. Statistical inference. Belmont, CA: Wadsworth, 1990.
17. Harris JM II, Gwaltney JM Jr. Incubation periods of experimental rhinovirus infection and illness. Clin Infect Dis 1996; 23:1287-90.
18. Arruda E, Pitkaranta A, Witek TJ, Doyle CA, Hayden FG. Frequency and natural history of rhinovirus infections in adults during autumn. J Clin Microbiol 1997; 35:2864-8.
19. Rao SS, Hendley JO, Hayden FG, Gwaltney JM Jr. Symptom expression in natural and experimental rhinovirus colds. Am J Rhinol 1995; 9:49-52.
20. Howard JC Jr, Kantner TR, Lilienfield LS, et al. Effectiveness of antihistamines in the symptomatic management of the common cold. JAMA 1979; 242:2414-7.
21. Mäkelä MJ, Puhakka T, Ruuskanen O, et al. Viruses and bacteria in the etiology of the common cold. J Clin Microbiol 1998; 36:539-42.
22. Barsky AJ. Forgetting, fabricating, and telescoping: the instability of the medical history. Arch Intern Med 2002; 162:981-4.