Randomized controlled trial of clemastine fumarate for treatment of experimental rhinovirus colds

Clinical Infectious Diseases

Volumn 22, Issue 4, 1996, Pages 656-662

  Gwaltney Jr , Jack M ^a   Park, Joseph ^b   Paul, Richard A ^b   Edelman, David A ^b   O'Connor, Robert R ^b   Turner, Ronald B ^b  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CLEMASTINE FUMARATE; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; COMMON COLD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NOSE SECRETION; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINOVIRUS; SNEEZING; XEROSTOMIA;

EID: 0029824295     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinids/22.4.656     Document Type: Article

References (28)

1. West S, Brandon B, Stolley P, Rumrill R. A review of antihistamines and the common cold. Pediatrics 1975;56:100-7.
2. Smith MB, Feldman W. Over-the-counter cold medications. A critical review of clinical trials between 1950 and 1991. JAMA 1993;269: 2258-63.
3. Doyle WJ, McBride TP, Skoner DP, Maddern BR, Gwaltney JM Jr, Uhrin M. A double-blind, placebo-controlled clinical trial of the effect of chlorpheniramine on the response of the nasal airway, middle ear and eustachian tube to provocative rhinovirus challenge. Pediatr Infect Dis J 1988;7:229-38.
4. Gaffey MJ, Gwaltney JM Jr, Sastre A, Dressler WE, Sorrentino JV, Hayden FG. Intranasally and orally administered antihistamine treatment of experimental rhinovirus colds. Am Rev Respir Dis 1987;136:556-60.
5. Gwaltney JM Jr, Colonno RJ, Hamparian VV, Turner RB. Rhinovirus. In: Schmidt NJ, Emmonds RW, eds. Diagnostic procedures for viral, rickettsial and chlamydial infections. 6th ed. Washington, DC: American Public Health Association, 1989:604-44.
6. Gwaltney JM Jr, Moskalski PB, Hendley JO. Interruption of experimental rhinovirus transmission. J Infect Dis 1980;142:811-5.
7. Jackson GG, Dowling HF, Spiesman IG, Boand AV. Transmission of the common cold to volunteers under controlled conditions. The common cold as a clinical entity. Arch Intern Med 1958;101:267-78.
8. Kubo N, Shirakawa O, Kuno T, Tanaka C. Antimuscarinic effects of antihistamines: quantitative evaluation by receptor-binding assay. Jpn J Pharmacol 1987;43:277-82.
9. Widdicombe JG. Reflexes from the upper respiratory tract. In: Cherniack NS, Widdicombe JG. Handbook of physiology - the respiratory system II. Bethesda, Maryland: American Physiological Society, 1986:363-87.
10. Mygind N, Secher C, Kirkegaard J. Role of histamine and antihistamines in the nose. Eur J Respir Dis Suppl 1983;128:516-20.
11. Doyle WJ, Boehm S, Skoner DP. Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy. J Allergy Clin Immunol 1990;86:924-35.
12. Eggleston PA, Hendley JO, Gwaltney JM Jr, Eggleston AW, Leavell BS Jr. Histamine in nasal secretions. Int Arch Allergy Appl Immunol 1978;57:193-200.
13. Naclerio RM, Proud D, Kagey-Sobotka A, Lichtenstein LM, Hendley JO, Gwaltney JM Jr. Is histamine responsible for the symptoms of rhinovirus colds? A look at the inflammatory mediators following infection. Pediatr Infect Dis J 1988;7:218-22.
14. Igarashi Y, Skoner DP, Doyle WJ, White MV, Fireman P, Kaliner MA. Analysis of nasal secretions during experimental rhinovirus upper respiratory infections. J Allergy Clin Immunol 1993;92:722-31.
15. Gaffey MJ, Kaiser DL, Hayden FG. Ineffectiveness of oral terfenadine in natural colds: evidence against histamine as a medicator of common cold symptoms. Pediatr Infect Dis J 1988;7:223-8.
16. Berkowitz RB, Tinkelman DG. Evaluation of oral terfenadine for treatment of the common cold. Ann Allergy 1991;67:593-7.
17. Henauer SA, Gluck U. Efficacy of terfenadine in the treatment of common cold. A double-blind comparison with placebo. Eur J Clin Pharmacol 1988;34:35-40.
18. Gwaltney JM Jr, Hendley JO, Simon G, Jordan WS Jr. Rhinovirus infections in an industrial population. II. Characteristics of illness and antibody response. JAMA 1967;202:494-500.
19. Goust J. Immediate hypersensitivity. In: Virella G, ed. Introduction to medical immunology. 3rd ed. New York: Marcel Dekker, 1993:356.
20. Howard JC Jr, Kantner TR, Lilienfield LS, et al. Effectiveness of antihistamines in the symptomatic management of the common cold. JAMA 1979;242:2414-7.
21. Gwaltney JM Jr. Combined antiviral and antimediator treatment of rhinovirus colds. J Infect Dis 1992;166:776-82.
22. Wong L, Hendeles L, Weinberger M. Pharmacologic prophylaxis of allergic rhinitis: relative efficacy of hydroxyzine and chlorpheniramine. J Allergy Clin Immunol 1981;67:223-8.
23. Kemp JP, Buckley CE, Gershwin ME, et al. Multicenter, double-blind, placebo-controlled trial of terfenadine in seasonal allergic rhinitis and conjunctivitis. Ann Allergy 1985;54:502-9.
24. Gutkowski A, Bedard P, Del Carpio J, et al. Comparison of the efficacy and safety of loratadine, terfenadine, and placebo in the treatment of seasonal allergic rhinitis. J Allergy Clin Immunol 1988;81:902-7.
25. Falliers CJ, Brandon ML, Buchman E, et al. Double-blind comparison of cetirizine and placebo in the treatment of seasonal rhinitis. Ann Allergy 1991;66:257-62.
26. Berman BA. Perennial allergic rhinitis: clinical efficacy of a new antihistamine. J Allergy Clin Immunol 1990;86:1004-8.
27. Mansmann HC Jr, Altman RA, Berman BA, et al. Efficacy and safety of cetirizine therapy in perennial allergic rhinitis. Ann Allergy 1992; 68:348-53.
28. Garrison JC. Histamine, brandykinin, 5-hydroxytryptamine, and their antagonists. In: Gilman AG, Rall TW, Nies AS, Taylor P, eds. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1990:586.