Variations in spare electron transport chain capacity: The answer to an old riddle?

Journal of Neuroscience Research

Volumn 71, Issue 6, 2003, Pages 759-762

  Fern, Robert ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Brain injury; CNS; Cyanide; Mitochondria; Rotenone

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3 NITROPROPIONIC ACID; ADENOSINE TRIPHOSPHATE; CYANIDE; NEUROTOXIN; PESTICIDE; POISON; ROTENONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BASAL GANGLION; BRAIN CORTEX; BRAIN INJURY; BRAIN METABOLISM; BRAIN MITOCHONDRION; CONTROLLED STUDY; CORPUS CALLOSUM; CORPUS STRIATUM; DISEASE PREDISPOSITION; ELECTRON TRANSPORT; GLUCOSE UTILIZATION; HIPPOCAMPUS; INTOXICATION; NERVE CONDUCTION; NEUROLOGIC DISEASE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESPIRATORY CHAIN; SHORT SURVEY; SPECIES DIFFERENCE; STRAIN DIFFERENCE; THALAMUS; WHITE MATTER;

ANIMALS; BRAIN; ELECTRON TRANSPORT; ENZYME INHIBITORS; GLUCOSE; MALE; OXIDOREDUCTASES; RATS;

EID: 0037443672     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10553     Document Type: Short Survey

References (27)

1. Beal MF, Brouillet E, Jenkins BG, Ferrante RJ, Kowall NW, Miller JM, Storey E, Srivastava R, Rosen BR, Hyman BT. 1993. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J Neurosci 13:4181-4192.
2. Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT. 2000. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 3:1301-1306.
3. d'Avella D, Cicciarello R, Gagliardi ME, Albiero F, Mesiti M, Russi E, D'Aquino A, Tomasello F. 1994. Progressive perturbations in cerebral energy metabolism after experimental whole-brain radiation in the therapeutic range. J Neurosurg 81:774-779.
4. Duelli R, Staudt R, Duembgen L, Kuschinsky W. 1999. Increase in glucose transporter densities of Glut3 and decrease of glucose utilization in rat brain after one week of hypoglycemia. Brain Res 831:254-262.
5. Ferrante RJ, Schulz JB, Kowall NW, Beal MF. 1997. Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra. Brain Res 753:157-162.
6. Gorell JM, Johnson CC, Rybicki BA, Peterson EL, Richardson RJ. 1998. The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living. Neurology 50:1346-1350.
7. Hakim AM, Pappius HM. 1983. Sequence of metabolic, clinical, and histological events in experimental thiamine deficiency. Ann Neurol 13:365-375.
8. Hamilton BF, Gould DH. 1987. Nature and distribution of brain lesions in rats intoxicated with 3-nitropropionic acid: a type of hypoxic (energy deficient) brain damage. Acta Neuropathol 72:286-297.
9. Hicks SP. 1950. Brain metabolism in vivo. Arch Pathol 50:545-561.
10. Hirano A, Levine S, Zimmerman HM. 1967. Experimental cyanide encephalopathy: electron microscopic observations of early lesions in white matter. J Neuropathol Exp Neurol 26:200-213.
11. +), the neurotoxic metabolite of MPTP. Biochem Biophys Res Commun 148:684-693.
12. Horinaka N, Artz N, Cook M, Holmes C, Goldstein DS, Kennedy C, Sokoloff L. 1997. Effects of elevated plasma epinephrine on glucose utilization and blood flow in conscious rat brain. Am J Physiol 272: H1666-H1671.
13. Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH. 1985. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci USA 82:2173-2177.
14. Lessell S. 1971. Experimental cyanide optic neuropathy. Arch Ophthalmol 86:194-204.
15. Levine S, Hirano A, Zimmerman HM. 1967. Experimental cyanide encephalopathy: electron microscopic observations of early lesions in white matter. J Neuropathol Exp Neurol 26:172-174.
16. McCracken E, Dewar D, Hunter AJ. 2001. White matter damage following systemic injection of the mitochondrial inhibitor 3-nitropropionic acid in rat. Brain Res 892:329-335.
17. Morimoto Y, Wu B, Bart RD, Pearlstein RD, Warner DS. 1998. Effects of NMDA receptor glycine recognition site antagonism on cerebral metabolic rate for glucose and cerebral blood flow in the conscious rat. Brain Res 779:170-176.
18. Nehlig A, de Vasconcelos AP, Boyet S. 1988. Quantitative autoradiographic measurement of local cerebral glucose utilization in freely moving rats during postnatal development. J Neurosci 8:2321-2333.
19. Orzi F, Schuier F, Fieschi C. 1981. Effects of naftidrofuryl on local cerebral glucose utilization in the rat. J Cereb Blood Flow Metab 1:137-140.
20. Otsuka T, Wei L, Bereczki D, Acuff V, Patlak C, Fenstermacher J. 1990. Pentobarbital produces dissimilar changes in glucose influx and utilization in brain. Am J Physiol 261:R265-R275.
21. Ouary S, Bizat N, Altairac S, Menetrat H, Mittoux V, Conde F, Hantraye P, Brouillet E. 2000. Major strain differences in response to chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid in rats: implications for neuroprotection studies. Neuroscience 97:521-530.
22. Penney DG. 1990. Acute carbon monoxide poisoning: animal models: a review. Toxicology 62:123-160.
23. Pulsinelli WA, Brierley JB. 1979. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 10:267-272.
24. Sokoloff L. 1981. Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucose. J Cereb Blood Flow Metab 1:7-36.
25. Talpade DJ, Greene JG, Higgins DS Jr, Greenamyre JT. 2000. In vivo labeling of mitochondrial complex I (NADH:ubiquinone oxidoreductase) in rat brain using [(3)H]dihydrorotenone. J Neurochem 75:2611-2621.
26. Wong-Riley MT. 1989. Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. Trends Neurosci 12:94-101.
27. Zhang C, Wong-Riley MT. 2000. Synthesis and degradation of cytochrome oxidase subunit mRNAs in neurons: differential bigenomic regulation by neuronal activity. J Neurosci Res 60:338-344.