The carcinogen (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene induces Cdc25B expression in human bronchial and lung cancer cells

Cancer Research

Volumn 63, Issue 4, 2003, Pages 771-775

  Oguri, Tetsuya ^a,b   Singh, Shivendra V ^a   Nemoto, Kaoru ^a   Lazo, John S ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7,8 DIHYDROXYBENZO[A]PYRENE 9,10 OXIDE; 7,8,9,10 TETRAHYDRO 7,8 DIHYDROXYBENZO[A]PYRENE 9,10 OXIDE; CARCINOGEN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE 1; PROTEIN CDC25B; UNCLASSIFIED DRUG;

ARTICLE; BRONCHUS CANCER; BRONCHUS MUCOSA; CANCER CELL CULTURE; CELL DIFFERENTIATION; DISEASE COURSE; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; LONG TERM EXPOSURE; LUNG CANCER; LUNG CARCINOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; ADENOCARCINOMA, BRONCHIOLO-ALVEOLAR; BRONCHI; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; CELL DIVISION; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; LUNG NEOPLASMS; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0037443062     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Draetta, G., and Eckstein, J. Cdc25 protein phosphatase in cell proliferation. Biochim. Biophys. Acta. 1322: M53-M63, 1997.
2. Galaktionov, K., Lee, A. K., Eckstein, J., Draetta, G., Meckler, J., Loda, M., and Beach, D. CDC25 phosphatase as potential human oncogenes. Science (Wash. DC). 269: 1575-1577, 1995.
3. Gasparotto, D., Maestro, R., Piccinin, S., Vukosavljevic, T., Barzan, L., Sulfaro, S., and Boiocchi, M. Overexpression of Cdc25A and Cdc25B in head and neck cancers. Cancer Res., 57: 2366-2368, 1997.
4. Takemasa, I., Yamamoto, H., Sekimoto, M., Ohue, M., Noura, S., Miyake, Y., Matsumoto, T., Aihara, T., Tomita, N., Tamaki, Y., Sakita, I., Kikkawa, N., Matsuura, N., Shiozaki, H., and Monden, M. Overexpression of Cdc25B phosphatase as a novel maker of poor prognosis of human colorectal carcinoma. Cancer Res., 60: 3043-3050, 2000.
5. Sasaki, H., Yukiue, H., Kobayashi, Y., Tanahashi, M., Moriyama, S., Nakashima, Y., Fukai, I., Kiriyama, M., Yamakawa, Y., and Fujii, Y. Expression of Cdc25B gene as a prognosis maker in non-small cell lung cancer. Cancer Lett., 173: 187-192, 2001.
6. Ma, Z-Q, Liu, Z., Ngan, E. S. W., and Tsai, S. Y. Cdc25B functions as a novel coctivator for the steroid receptor. Mol. Cell. Biol., 21: 8056-8067, 2001.
7. Wang, Z., Wang, M., Lazo, J. S., and Carr, B. I. Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase. J. Biol. Chem., 277: 19470-19475, 2002.
8. Zou, X., Tsutsui, T., Ray, D., Blomquist, J. F., Ichijo, H., Ucker, D. S., and Kiyokawa, H. The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1. Mol. Cell. Biol., 21: 4818-4828, 2001.
9. Mao, L., Lee, J. S., Kurie, J. M., Fan, Y. H., Lippman, S. M., Lee, J. J., Ro, J. Y., Broxson, A., Yu, R., Morice, R. C., Kemp, B. L., Khuri, F. R., Walsh, G. L., Hittelmann, W. N., and Hong, W. F. Clonal genetic alterations in the lungs current and former smokers. J. Natl. Cancer Inst. (Bethesda), 89: 857-862, 1997.
10. Thakker, D. R., Yagi, H., Levin, W., Wood, A. W., Conney, A. H., and Jerina, D. M. Polycyclic aromatic hydrocarbons: metabolic activation to ultimate carcinogens, In: M. W. Anders (ed.), Bioactivation of Foreign Compounds, pp. 177-242, New York: Academic Press, 1985.
11. Buening, M. K., Wislocki, P. G., Levin, W., Yagi, H., Thakker, D. R., Akagi, H., Koreeda, M., Jerina, D. M., and Conney, A. H. Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene-7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7β,8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. Proc. Nat. Acad. Sci. USA, 75: 5358-5361, 1978.
12. Rubin, H. Synergistic mechanism in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updates. Carcinogenesis (Lond.), 22: 1903-1930, 2001.
13. Ma, Z-Q., Chua, S. S., DeMayo, F. J., and Tsai, S. Y. Induction of mammary gland hyperplasia in transgenic mice over-expressing human Cdc25B. Oncogene, 18: 4564-4576, 1999.
14. Yao, Y., Slosberg, E. D., Wang, L., Hibshoosh, H., Zhang, Y-J. Xing, W-Q., Santella, R. M., and Weinstein, I. B. Increased susceptibility to carcinogen-induced mammary tumors in MMTV-Cdc25B transgenic mice. Oncogene, 18: 5159-5166, 1999.
15. Ke, Y., Reddel, R. R., Gerwin, B. I., Miyashita, M., McMenamin, M., Lechner, J. F., and Harris, C. C. Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation. Differentiation, 33: 60-66, 1988.
16. Baldin, V., Cans, C., Superti-Furga, G., and Ducommun, B. Alternative splicing of human Cdc25B tyrosine phosphatase. Possible implications for growth control? Oncogene, 14: 2485-2495, 1997.
17. Denissenko, M. F., Pao, A., Tang, M., and Pfeifer, G. P. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in p53. Science (Wash. DC), 274: 430-432, 1995.
18. Dittrich, K., and Krugh, T. R. Mapping of (+/-)-anti-benzo[a]pyrene diol epoxide adducts to human c-Ha-ras1 protooncogene. Chem. Res. Toxicol., 4: 277-281, 1991.
19. Jeffy, B. D., Chimomas, R. B., Chen, E. J., Gudas, J. M., and Romagnolo, D. Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: requirement for metabolism of benzo[a]pyrene to 7r,8t-dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. Cancer Res., 62: 113-121, 2002.
20. Shen, E. S., and Whitlock, J. P., Jr. Protein-DNA interactions at a dioxin-responsive enhancer. J. Biol. Chem., 267: 6815-6819, 1992.
21. 1 arrest in nontransformed and malignant lung cell lines. Toxicol. Appl. Pharmacol., 173: 105-113, 2001.
22. Lazo, J. S., Nemoto, K., Pestell, K. E., Cooley, K., Southwick, E. C., Mitchell, D. A., Furey, W., Gussio, R., Zaharevitz, D. W., Joo, B., and Wipf, P. Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. Mol. Pharmacol., 61: 720-728, 2002.