Loss of dendritic connectivity in CA1, CA2, and CA3 neurons in hippocampus in rat under aluminum toxicity: Antidotal effect of pyridoxine

Brain Research Bulletin

Volumn 59, Issue 6, 2003, Pages 421-427

  Sreekumaran, E ^a,d   Ramakrishna, T ^a   Madhav, T R ^b   Anandh, D ^c   Prabhu, B M ^c   Sulekha, S ^c   Bindu, P N ^c   Raju, T R ^c  

^a UNIVERSITY OF CALICUT   (India)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Aluminum; Dendritic branches; Hippocampus; Pyridoxine

Indexed keywords

ALUMINUM CHLORIDE; PYRIDOXINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CEREBROSPINAL FLUID; CLINICAL FEATURE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DENDRITE; HIPPOCAMPUS; HISTOCHEMISTRY; MALE; NERVE BLOCK; NERVE CELL; NERVE CONDUCTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ALUMINUM COMPOUNDS; ANIMALS; ANTIDOTES; CELL SIZE; CELL SURVIVAL; CELLS, CULTURED; CHLORIDES; DENDRITES; HIPPOCAMPUS; MALE; NEURAL PATHWAYS; NEURONS; PYRIDOXINE; RATS; RATS, WISTAR; SILVER STAINING;

EID: 0037441576     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(02)00944-9     Document Type: Article

References (32)

1. Flaten T.P. Aluminium as a risk factor for Alzheimer's disease, with emphasis on drinking water. Brain. Res. Bull. 55(2):2001;187-196.
2. McLachlan D.R.C. Aluminium and the risk for Alzheimer's disease. Environmetrics. 6:1995;233-275.
3. Savory J., Exley C., Forbes W.F., Huang Y., Joshi J.G., Kruck T., McLachlan D.R.C., Wakayama I. Can the controversy of the role of aluminum in Alzheimer's disease be resolved? What are the suggested approaches to this controversy and methodological issues to be considered? J. Toxicol. Environ. Health. 48:1996;615-635.
4. Huang Y., Herman M.M., Liu J., Katsetos C.D., Wills M.R., Savory J. Neurofibrillary lesions in experimental aluminum-induced encephalopathy and Alzheimer's disease share immunoreactivity for amyloid precursor protein Aβ, α1-antichymotrypsin and ubiquitin-protein conjugates. Brain. Res. 771:1997;213-220.
5. Ramakrishna T., Vatsala S., Shobi V., Sreekumaran E., Madhav T.R., Ramesh J., Easwaran K.R.K. Betaine reverses the toxic effects of aluminum: Implications in Alzheimer's disease and AD-like pathology. Curr. Sci. 75:1998;1153-1156.
6. Savory J., Rao J.K.S., Huang Y., Letada P.R., Herman M.M. Age-related hippocampal changes in Bcl-2: Bax ratio, oxidative stress, redox-active iron and amyloid precursor protein associated with aluminum-induced neurodegeneration. Increased susceptibility with aging. Neurotoxicol. 20:1999;805-817.
7. Sreekumaran E., Ramakrishna T. Spatial memory loss in rat due to aluminium toxicity is reversed by desferrioxamine/pyridoxine. Alzheimer's Rep. 5:2002;25-28.
8. McLachlan D.R.C., Dalton A.J., Kruck T.P.A., Bell M.Y., Smith W.L., Kalow C.V., Andrews D.F. Intramuscular desferrioxamine in patients with Alzheimer's disease. Lancet. 337:1991;1304-1308.
9. Platt B., Carpenter D.O., Bussel O.B., Reymann K.G., Riedel G. Aluminum impairs hippocampal long-term potentiation in rats in vitro and in vivo. Exp. Neurol. 134(1):1995;73-86.
10. Meiri H., Banin E., Roll M., Rousseau A. Toxic effects of aluminum on nerve cells and synaptic transmission. Prog. Neurobiol. 40(1):1993;89-121.
11. Whitehouse D.J., Price D.L., Clark A.W., Coyle J.T., DeLong M.R. Alzheimer's disease: Evidence for the selective loss of cholinergic neurons in the nucleus basalis. Ann. Neurol. 10:1981;122-126.
12. Cain D.P. Testing the NMDA, long-term potentiation, and cholinergic hypotheses of spatial learning. Neurosci. Behav. Res. 22:1998;181-193.
13. Sreekumaran, E. Electrophysiological study on the CA1, CA2 and CA3 neurons of the hippocampal slices in rat: Effect of aluminium and antidotes, betaine, pyridoxine and desferrioxamine. Ph.D. thesis submitted to the University of Calicut, Department of Life Sciences, Kerala, India; 2002.
14. Amaral, D. G.; Witter, M. P. Hippocampal formation. In: The rat nervous system, 2nd ed. San Diego, USA: Academic Press; 1995:443-493.
15. Sokolov M.V., Kleschevnikov A.M. Atropine suppresses associative LTP in the CA1 region of rat hippocampal slices. Brain Res. 672:1995;281-284.
16. Mukkadan J.K., Ramakrishna T. Retinal development in normal and Vitamin B1, B2 and B6 deficient rats. Ind. J. Physiol. Pharmacol. 26:1982;84.
17. Krishna A.P., Ramakrishna T. Effects of pyridoxine deficiency on exploratory behaviour of rats. Int. J. Psychophysiol. 2:1984;39-43.
18. Kirksey A., Morre D.M., Wasynezuk A.Z. Vitamin B6: Neuronal development in Vitamin B6 deficiency. Ann. N.Y. Acad. Sci. 585:1990;202-218.
19. Krishna A.P., Ramakrishna T. Effect of pyridoxine deficiency on maturation of neuromotor coordinations. Ind. J. Physiol. Pharmacol. 38(2):1994;113-116.
20. Ramakrishna T. Vitamins and brain development. Physiol. Res. 48:1999;175-187.
21. Dakshinamurti K. Vitamin B6. Ann. N.Y. Acad. Sci. 585:1990;1-570.
22. Geng M.-Y., Saito H., Katsuki H. Effects of Vitamin B6 and its related compounds on the survival of cultured brain neurons. Neurosci. Res. 24:1995;61-65.
23. Sankaranarayana Rao B.S., Raju T.R., Meti B.L. Long lasting structural changes in CA3 hippocampal and layer V motor cortical pyramidal neurons associated with self-stimulation - A quantitative Golgi study. Brain Res. Bull. 47:1998;95-101.
24. West M.J., Kawas C.H., Martin L.J., Troncoso J.C. The CA1 region of the human hippocampus is a hot spot in Alzheimer's disease. Ann. N.Y. Acad. Sci. 908:2000;255-259.
25. Kril J.J., Patel S., Harding A.J., Halliday G.M. Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation. Acta Neuropathol. 103:2002;370-376.
26. Terry R.D., Masliah E., Salmon D.P., Butters N., Deteresa R., Hill R., Hansen L.A., Katzman R. Physical basis of cholinergic alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30:1991;572-580.
27. Pearson R.C.A. Cortical connections and the pathology of Alzheimer's disease. Neurodegeneration. 5:1996;429-434.
28. Hallmayer J., Hossmann K.A., Mies G. Low dose of barbiturates for prevention of hippocampal lesions after brief ischemic episodes. Acta Neuropathol. 68:1985;27-31.
29. Dakshinamurti K., Singer W.D., Patterson J.A. Effect of pyridoxine deficiency in the neuronally mature rat. Int. J. Vitam. Nutr. Res. 57(2):1987;161-167.
30. Trombley P.Q. Selective modulation of GABAA receptors by aluminum. J. Neurophysiol. 80(2):1998;755-761.
31. Yan W., Wilson C.C., Haring J.H. 5-HT1a receptors mediate the neurotrophic effect of serotonin on developing dentate granule cells. Brain Res. Dev. Brain Res. 98(2):1997;185-190.
32. Norrholm S.D., Ouimet C.C. Chronic fluoxetine administration to juvenile rats prevents age-associated dendritic spine proliferation in hippocampus. Brain Res. 883(2):2000;205-215.