A novel skilled-reaching impairment in paw supination on the "good" side of the hemi-Parkinson rat improved with rehabilitation

Journal of Neuroscience

Volumn 23, Issue 2, 2003, Pages 579-586

  Vergara Aragon, Patricia ^a   Gonzalez, Claudia L R ^b   Whishaw, Ian Q ^a  

^a UNIVERSITY OF LETHBRIDGE   (Canada)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

6 hydroxydopamine; Dopamine and skilled movement; Dopamine depletion; Nigrostriatal lesion; Parkinson analog rat; Parkinson's disease; Parkinson's disease rat model; Parkinson's therapy; Rehabilitation and Parkinson's disease; Skilled reaching

Indexed keywords

DOPAMINE; OXIDOPAMINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR THERAPY; BODY POSTURE; BRADYKINESIA; CONTROLLED STUDY; FEMALE; FOOD; MOTOR DYSFUNCTION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; RIGIDITY; SENSORY DYSFUNCTION; SKILL; TASK PERFORMANCE; TRAINING; TREMOR; VIDEORECORDING;

EID: 0037439941     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-02-00579.2003     Document Type: Article

References (51)

1. Abrous DN, Shaltot ARA, Torres EM, Dunnett SB (1993a) Dopamine-rich grafts in the neostriatum and/or nucleus accumbens: effects on drug-induced behaviours and skilled paw-reaching. Neuroscience 53:187-197.
2. Abrous DN, Torres EM, Dunnett SB (1993b) Dopaminergic grafts implanted into the neonatal or adult striatum: comparative effects on rotation and paw reaching deficits induced by subsequent unilateral nigrostriatal lesions in adulthood. Neuroscience 54:657-668.
3. Barnéoud P, Descombris E, Aubin N, Abrous DN (2000) Evaluation of complex sensorimotor behaviours in rats with a partial lesion of the dopaminergic nigrostriatal system. Eur J Neurosci 12:322-336.
4. Bland ST, Pillai RN, Aronowski J, Grotta JC, Schallert T (2001) Early over-use and disuse of the affected forelimb after moderately severe intraluminal suture occlusion of the middle cerebral artery in rats. Behav Brain Res 126:33-41.
5. Cenci MA, Whishaw IQ, Schallert T (2002) Animal models of neurological deficits: how relevant is the rat? Nat Neurosci Rev 13:574-579.
6. Dean KH, Jones D, Playford ED, Ben-Shlomo Y, Clarke CE (2001) Physictherapy for patients with Parkinson's disease: a comparison of techniques. Cochrane Database Syst Rev 3:CD002817.
7. de Goede CJ, Keus SH, Kwakkel G, Wagenaar RC (2001) The effects of physical therapy in Parkinson's disease: a research synthesis. Arch Phys Med Rehabil 82:509-515.
8. Döbrössy MD, LeMoal M, Montaron M-F, Abrous N (2000) Influence of environment on the efficacy of intrastriatal dopaminergic grafts. Exp Neurol 165:172-183.
9. Dunnett SB, Whishaw IQ, Rogers DC, Jones GH (1987) Dopamine-rich grafts ameliorate whole body motor asymmetry and sensory neglect but not independent limb use in rats with 6-hydroxydopamine lesions. Brain Res 415:630-678.
10. Dunnett SB, Isacson O, Sirinathsinghji DJS, Clarke DJ, Björklund A (1988) Striatal grafts in rats with unilateral neostriatal lesions. III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching. Neuroscience 24:813-820.
11. Duvoisin RC (1978) Parkinson's disease. Raven: New York.
12. Eshkol N, Wachmann A (1958) Movement notation. London: Weidenfeld and Nicholson.
13. Fallon JH, Loughlin SE (1995) Substantia nigra. In: The rat nervous system (Paxinos G, ed), pp 215-232. San Diego: Academic.
14. Fricker RA, Annett LE, Torres EM, Dunnett SB (1996) The locus of a striatal ibotenic acid lesion affects the direction of drug-induced rotation and skilled forelimb use. Brain Res Bull 41:409-416.
15. Glavan A, Floran B, Erlij D, Aceves J (2001) Intrapallidal dopamine restores motor deficits induced by 6-hydroxydopamine in the rat. J Neural Transm 108:153-166.
16. Grabowski M, Brundin P, Johansson BB, Kontos HA (1993) Paw reaching, sensorimotor and rotational behavior after brain infarction in rats. Stroke 24:889-895.
17. Hefti F, Melamed E, Shakian BJ, Wurtman RJ (1980) Circling behavior in rats with partial unilateral nigrostriatal lesions: affect of amphetamine, apomorphine, and dopa. Pharmacol Biochem Behav 12:185-188.
18. Heimer L, Zahm DS, Alheid GA (1995) Basal ganglia. In: The rat nervous system (Paxinos G, ed), pp 579-614. San Diego: Academic.
19. Henderson JM, Annett LE, Ryan LJ, Chiang W, Hidaka S, Torres EM, Dunnett SB (1999) Subthalamic nucleus lesions induce deficits as well as benefits in the hemiparkinsonian rat. Eur J Neurosci 11:2749-2757.
20. Herrera-Marschitz M, Utsumi H, Ungerstedt U (1990) Scoliosis in rats with experimentally-induced hemiparkinsonism: dependence upon striatal dopamine denervation. J Neurol Neurosurg Psychiatry 53:39-43.
21. Jeyasingham RA, Baird AL, Meldrum A, Dunnett SB (2001) Differential effects of unilateral striatal and nigrostriatal lesions on grip strength, skilled paw reaching and drug-induced rotation in the rat. Brain Res Bull 55:541-548.
22. Kumar R, Lozano AM, Sime E, Halket E, Lang AE (1999) Comparative effects of unilateral and bilateral subthalamic nucleus deep brain stimulation. Neurology 11:561-566.
23. Lang AE, Lozano AM, Montgomery E, Duff J, Tasker R, Hutchinson W (1997) Posteroventral medial pallidotomy in advanced Parkinson's disease. N Engl J Med 337:1036-1042.
24. Lee CS, Sauer H, Björklund A (1996) Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by intrastriatal 6-hydroxydopamine in the rat. Neuroscience 27:641-653.
25. Lozano AM, Lang AE (1995) Reports on a study of the effect of globus pallidus (Gpi) on the motor functions in Parkinson's disease patients. Lancet 346:1383-1387.
26. Marshall JF, Ungerstedt U (1977) Supersensitivity to apomorphine following destruction of the ascending dopamine neurons: quantification using the rotational model. Eur J Pharmacol 41:361-367.
27. Martin JP (1967) The basal ganglia and posture. London: Pittman.
28. Merello M, Nouzeilles MI, Kuzis G, Commarota A, Sabe L, Betti O, Starkstein S, Leiguarda R (1999) Unilateral radiofrequency lesion versus electro-stimulation of posteroventral pallidum: a prospective randomized comparison. Mov Disord 14:50-56.
29. Metz GAS, Ballermann M, Whishaw IQ (2001) Chronic levodopa therapy does not improve skilled reach accuracy or reach range on a pasta matrix reaching task in 6-OHDA dopamine depleted (hemiparkinson analogue) rats. Eur J Neurosci 14:27-37.
30. Miklyaeva EI, Castañeda E, Whishaw IQ (1994) Skilled reaching deficits in unilateral dopamine-depleted rats: impairments in movement and posture and compensatory adjustments. J Neurosci 14:7148-7158.
31. Miklyaeva EI, Martens DJ, Whishaw IQ (1995) Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine depletion in rats. Brain Res 681:23-40.
32. Montoya CP, Astell S, Dunnett SB (1990) Effects of nigral and striatal grafts on skilled forelimb use in the rat. Prog Brain Res 82:459-466.
33. Montoya CP, Campbell-Hope KD, Dunnett SB (1991) The "staircase test": a measure in independent forelimb reaching and grasping abilities in rats. J Neurosci Methods 36:219-228.
34. Moore AE, Cicchetti F, Hennen J, Isacson O (2001) Parkinsonian motor deficits are reflected by proportional A9/A10 dopamine neuron degeneration in the rat. Exp Neurol 172:363-376.
35. Nikkhah G, Duan W-M, Knappe U, Jökicke A, Björklund A (1993) Restoration of complex sensorimotor behavior and skilled forelimb use by a modified nigral cell suspension transplantation approach in the rat Parkinson model. Neuroscience 56:33-43.
36. Obwegeser AA, Utti RJ, Witte RJ, Lucas JA, Turk MF, Wharen Jr RE (2001) Quantitative and qualitative outcome measures after thalamic deep brain stimulation to treat disabling tremors. Neurosurgery 48:281-284.
37. Olsson M, Nikkhah G, Bentlage C, Björklund A (1995) Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J Neurosci 15:3863-3875.
38. Parent A, Hazrati LN (1995) Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop. Brain Res Brain Res Rev 20:91-127.
39. Paxinos G, Watson C (1998) The rat brain. New York: Academic.
40. Robinson TE, Castãeda E, Whishaw IQ (1990) Compensatory changes in striatal dopamine neurons following recovery from injury induced by 6-OHDA or methamphetamine: a review of evidence from microdialysis studies. Can J Psychol 44:253-275.
41. Schallert T, De Ryck M, Whishaw IQ, Ramirez VD, Teitelbaum P (1979) Excessive bracing reactions and their control by atropine and L-DOPA in an animal analog of Parkinsonism. Exp Neurol 64:33-43.
42. Schultz Q (1982) Depletion ofdopamine in the striatum as an experimental model of Parkinsonism: direct effects and adaptive mechanisms. Prog Neurobiol 8:121-166.
43. Schwarting RK, Huston JP (1996) The unilateral 6-hydroxydopamine lesion model in behavioural brain research analysis of functional deficits, recovery and treatments. Prog Neurobiol 50:275-331.
44. Tillerson JL, Cohen AD, Philhower J, Miller GW, Zigmond MJ, Schallert T (2001) Forced limb-use effects on the behavioral and neurochemical effects of 6-hydroxydopamine. J Neurosci 21:4427-4435.
45. Ungerstedt U (1971) Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta Scand 82 [Suppl 367]:96-122.
46. Whishaw IQ (2000) Loss of the innate cortical engram for action patterns used in skilled reaching and the development of behaviour compensation following motor cortex lesions in the rat. Neuropharmacology 39:788-805.
47. Whishaw IQ, Metz GA (2002) Absence of impairments or recovery mediated by the uncrossed pyramidal tract in the rat versus enduring deficits produced by the crossed pyramidal tract. Behav Brain Res 134:323-326.
48. Whishaw IQ, Pellis SM (1990) The structure of skilled forelimb reaching in the rat: a proximally driven movement with a single distal rotatory component. Behav Brain Res 41:49-59.
49. Whishaw IQ, O'Connor WT, Dunnett SB (1986) The contributions of motor cortex, nigrostriatal dopamine, and caudate-putamen to skilled forelimb use in the rat. Brain 109:805-843.
50. Whishaw IQ, Castañeda E, Gorny BP (1992) Dopamine and skilled limb use in the rat: more severe bilateral impairments follow substantia nigra than sensorimotor cortex 6-hydroxydopamine injection. Behav Brain Res 47:89-92.
51. Whishaw IQ, Woodward NC, Miklyaeva E, Pellis SM (1997) Analysis of limb use by control rats and unilateral DA-depleted rats in the Montoya staircase test: movements, impairments, and compensatory strategies. Behav Brain Res 89:167-177.