Improved up-and-down designs for phase I trials

Statistics in Medicine

Volumn 22, Issue 1, 2003, Pages 69-82

  Ivanova, Anastasia ^a   Montazer Haghighi, Aliakbar ^b   Mohanty, Sri Gopal ^c   Durham, Stephen D ^d  

^a IL   (United States)

^b BENEDICT COLLEGE   (United States)

^c MCMASTER UNIVERSITY   (Canada)

^d UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Continual reassessment method; Dose finding; Phase I trial; Up and down design

Indexed keywords

DRUG;

ARTICLE; BIOSTATISTICS; CANCER PATIENT; CYTOTOXICITY; DOSE CALCULATION; DOSE RESPONSE; DRUG OVERDOSE; EMPIRICISM; EXPERIMENTAL DESIGN; HUMAN; OPTIMAL DRUG DOSE; PHASE 1 CLINICAL TRIAL; PROBABILITY; SAMPLE SIZE; SIMULATION;

CLINICAL TRIALS, PHASE I; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; PHARMACEUTICAL PREPARATIONS; RESEARCH DESIGN;

EID: 0037438434     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/sim.1336     Document Type: Article

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