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Volumn 987, Issue 1-2, 2003, Pages 249-256
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Determination of PNU-248686A, a novel matrix metalloproteinase inhibitor, in human plasma by liquid chromatography-tandem mass spectrometry, following protein precipitation in the 96-well plate format
a
a
Lab Drug Metab
(Italy)
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Author keywords
Enzyme inhibitors; Matrix metalloproteinase inhibitors; PNU 248686A; Sodium (2R) 3 ( (4 chloro(1, 1 biphenyl) 4 yl sulfonyl) 2 hydroxy 2 (phenylsulfanyl)methyl propanoate
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Indexed keywords
AMMONIUM COMPOUNDS;
MASS SPECTROMETRY;
METHANOL;
NEGATIVE IONS;
PRECIPITATION (CHEMICAL);
PROTEINS;
SODIUM;
HUMAN PLASMA;
LIQUID CHROMATOGRAPHY;
ACETONITRILE;
AMMONIUM FORMATE;
BUFFER;
MATRIX METALLOPROTEINASE INHIBITOR;
PNU 248686A;
SODIUM 3 [[4' CHLORO(1,1' BIPHENYL) 4 YL]SULFONYL] 2 HYDROXY 2 [(PHENYLSULFANYL)METHYL]PROPANOATE;
UNCLASSIFIED DRUG;
ACCURACY;
ANALYTIC METHOD;
CONFERENCE PAPER;
CONTROLLED STUDY;
DRUG BLOOD LEVEL;
DRUG DETERMINATION;
FLOW RATE;
HUMAN;
LIQUID CHROMATOGRAPHY;
NORMAL HUMAN;
PH;
PRIORITY JOURNAL;
TANDEM MASS SPECTROMETRY;
BIPHENYL COMPOUNDS;
CALIBRATION;
CHROMATOGRAPHY, LIQUID;
HUMANS;
MASS SPECTROMETRY;
MATRIX METALLOPROTEINASES;
PROTEASE INHIBITORS;
REPRODUCIBILITY OF RESULTS;
SENSITIVITY AND SPECIFICITY;
SULFONES;
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EID: 0037435995
PISSN: 00219673
EISSN: None
Source Type: Journal
DOI: 10.1016/S0021-9673(02)01907-6 Document Type: Article |
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Times cited : (7)
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References (8)
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