Adenovirus-mediated gene transfer of ICOSIg fusion protein ameliorates ongoing experimental autoimmune myocarditis

Human Gene Therapy

Volumn 14, Issue 6, 2003, Pages 521-532

  Matsui, Yutaka ^a,b   Okamoto, Hiroshi ^b   Inobe, Manabu ^a   Jia, Nan ^b   Shimizu, Toshihiro ^b   Akino, Masatoshi ^b   Sugawara, Takeshi ^b   Tezuka, Katsunari ^c   Nakayama, Yousuke ^a   Morimoto, Junko ^a   Kimura, Chiemi ^a   Kon, Shigeyuki ^a   Miyazaki, Tadaaki ^a   Kitabatake, Akira ^b   Uede, Toshimitsu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c JT Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ADEX1CAICOS1G FUSION PROTEIN; ADEX1CALACZ FUSION PROTEIN; B7 ANTIGEN; CD28 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; GENE PRODUCT; HYBRID PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DISEASE COURSE; DISEASE MODEL; EXPERIMENTAL AUTOIMMUNE MYOCARDITIS; EXPERIMENTATION; GENE TRANSFER; HEART; IMMUNIZATION; IMMUNOPATHOLOGY; INHIBITION KINETICS; LYMPH NODE; MALE; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; MYOCARDITIS; NONHUMAN; RAT; SPLEEN; STATISTICAL SIGNIFICANCE; SURVIVAL RATE; TREATMENT OUTCOME; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADENOVIRIDAE; ANIMALS; ANTIBODIES; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; AUTOIMMUNE DISEASES; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; IMMUNOGLOBULINS; LYMPH NODES; MALE; MYOCARDITIS; MYOCARDIUM; MYOSINS; PROTEINS; RATS; RATS, INBRED LEW; RECOMBINANT FUSION PROTEINS; SPLEEN; T-LYMPHOCYTES;

ADENOVIRIDAE; ANIMALIA;

EID: 0037431267     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303403764539314     Document Type: Article

References (26)

1. BLUESTONE, J.A. (1995). New perspectives of CD28-B7-mediated T cell costimulation. Immunity 2, 555-559.
2. DAMOISEAUX, J.G., YAGITA, H., OKUMURA, K., and VAN BREDA VRIESMAN, P.J. (1998). Costimulatory molecules CD80 and CD86 in the rat: Tissue distribution and expression by antigen-presenting cells. J. Leukoc. Biol. 64, 803-809.
3. DONG, C., JUEDES, A.E., TEMANN, U.A., SHRESTA, S., ALLISON, J.P., RUDDLE, N.H., and FLAVELL, R.A. (2001). ICOS costimulatory receptor is essential for T-cell activation and function. Nature 409, 97-101.
4. DRORY, Y., TURETZ, Y., HISS, Y., LEV, B., FISMAN, E.Z., PINES, A., and KRAMER, M.R. (1991). Sudden unexpected death in persons less than 40 years of age. Am. J. Cardiol. 68, 1388-1392.
5. GONZALO, J.A., TIAN, J., DELANEY, T., CORCORAN, J., ROTTMAN, J.B., LORA, J., AL-GARAWI, A., KROCZEK, R., GUTIERREZ-RAMOS, J.C., and COYLE, A.J. (2001). ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nat. Immunol. 2, 597-604.
6. GREWAL, I.S., and FLAVELL, R.A. (1998). CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16, 111-135.
7. ISHIYAMA, S., HIROE, M., NISHIKAWA, T., ABE, S., SHIMOJO, T., ITO, H., OZASA, S., YAMAKAWA, K., MATSUZAKI, M., MOHAMMED, M.U., NAKAZAWA, H., KASAJIMA, T., and MARUMO, F. (1997). Nitric oxide contributes to the progression of myocardial damage in experimental autoimmune myocarditis in rats. Circulation 95, 489-496.
8. KHAYYAMIAN, S., HUTLOFF, A., BUCHNER, K., GRAFE, M., HENN, V., KROCZEK, R.A., and MAGES, H.W. (2002). ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells. Proc. Natl. Acad. Sci. U.S.A. 99, 6198-6203.
9. KODAMA, M., MATSUMOTO, Y., and FUJIWARA, M. (1992). In vivo lymphocyte-mediated myocardial injuries demonstrated by adoptive transfer of experimental autoimmune myocarditis. Circulation 85, 1918-1926.
10. KODAMA, M., HANAWA, H., SAEKI, M., HOSONO, H., INOMATA, T., SUZUKI, K., and SHIBATA, A. (1994). Rat dilated cardiomyopathy after autoimmune giant cell myocarditis. Circ. Res. 75, 278-284.
11. LAUER, B., PADBERG, K., SCHULTHEISS, H.P., and STRAUER, B.E. (1994). Autoantibodies against human ventricular myosin in sera of patients with acute and chronic myocarditis. J. Am. Coll. Cardiol. 23, 146-153.
12. MATSUI, Y., INOBE, M., OKAMOTO, H., CHIBA, S., SHIMIZU, T., KITABATAKE, A., and UEDE, T. (2002). Blockade of T cell costimulatory signals using adenovirus vectors prevents both the induction and the progression of experimental autoimmune myocarditis. J. Mol. Cell. Cardiol. 34, 279-295.
13. MURAKAMI, U., UCHIDA, K., and HIRATSUKA, T. (1976). Cardiac myosin from pig heart ventricle. Purification and enzymatic properties. J. Biochem. (Tokyo) 80, 611-619.
14. NAKAGAWA, I., MURAKAMI, M., IJIMA, K., CHIKUMA, S., SAITO, I., KANEGAE, Y., ISHIKURA, H., YOSHIKI, T., OKAMOTO, H., KITABATAKE, A., and UEDE, T. (1998). Persistent and secondary adenovirus-mediated hepatic gene expression using adenovirus vector containing CTLA4IgG. Hum. Gene Ther. 9, 1739-1745.
15. OKURA, Y., YAMAMOTO, T., GOTO, S., INOMATA, T., HIRONO, S., HANAWA, H., FENG, L., WILSON, C.B., KIHARA, I., IZUMI, T., SHIBATA, A., and AIZAWA, Y. (1997). Characterization of cytokine and iNOS mRNA expression in situ during the course of experimental autoimmune myocarditis in rats. J. Mol. Cell. Cardiol. 29, 491-502.
16. OKURA, Y., TAKEDA, K., HONDA, S., HANAWA, H., WATANABE, H., KODAMA, M., IZUMI, T., AIZAWA, Y., SEKI, S., and ABO, T. (1998). Recombinant murine interleukin-12 facilitates induction of cardiac myosin-specific type 1 helper T cells in rats. Circ. Res. 82, 1035-1042.
17. OZKAYNAK, E., GAO, W., SHEMMERI, N., WANG, C., GUTIERREZ-RAMOS, J.C., AMARAL, J., QIN, S., ROTTMAN, J.B., COYLE, A.J., and HANCOCK, W.W. (2001). Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection. Nat. Immunol. 2, 591-596.
18. ROTTMAN, J.B., SMITH, T., TONRA, J.R., GANLEY, K., BLOOM, T., SILVA, R., PIERCE, B., GUTIERREZ-RAMOS, J.C., OZKAYNAK, E., and COYLE, A.J. (2001). The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nat. Immunol. 2, 605-611.
19. SAYEGH, M.H., and TURKA, L.A. (1998). The role of T-cell costimulatory activation pathways in transplant rejection. N. Engl. J. Med. 338, 1813-1821.
20. SCHWARTZ, R.H. (1990). A cell culture model for T lymphocyte clonal anergy. Science 248, 1349-1356.
21. SPERLING, A.I. (2001). ICOS costimulation: Is it the key to selective immunotherapy? Clin. Immunol. 100, 261-262.
22. H2 cells anymore. Nat. Immunol. 2, 573-574.
23. SPORICI, R.A., BESWICK, R.L., VON ALLMEN, C., RUMBLEY, C.A., HAYDEN-LEDBETTER, M., LEDBETTER, J.A., and PERRIN, P.J. (2001). ICOS ligand costimulation is required for T-cell encephalitogenicity. Clin. Immunol. 100, 277-288.
24. STULL, L.B., DIIULIO, N.A., YU, M., MCTIERNAN, C.F., RATLIFF, N.B., TUOHY, V.K., and MORAVEC, C.S. (2000). Alterations in cardiac function and gene expression during autoimmune myocarditis in mice. J. Mol. Cell. Cardiol. 32, 2035-2049.
25. TAMATANI, T., TEZUKA, K., and HANZAWA-HIGUCHI, N. (2000). AILIM/ICOS: a novel lymphocyte adhesion molecule. Int. Immunol. 12, 51-55.
26. WOODRUFF, J.F. (1980). Viral myocarditis. A review. Am. J. Pathol. 101, 425-484.