Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 5, 2003, Pages 867-872

  Hattori, Kazuo ^a   Kohchi, Yasunori ^a   Oikawa, Nobuhiro ^a   Suda, Hitomi ^a   Ura, Masako ^a   Ishikawa, Tohru ^a   Miwa, Masanori ^a   Endoh, Mika ^a   Eda, Hiroyuki ^a   Tanimura, Hiromi ^a   Kawashima, Akira ^a   Horii, Ikuo ^a   Ishitsuka, Hideo ^a   Shimma, Nobuo ^a  

^a NIPPON ROCHE RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAPECITABINE; CYTIDINE DEAMINASE; DIHYDROPYRIMIDINE DEHYDROGENASE; ENZYME INHIBITOR; ESTERASE; FLUOROURACIL; PRODRUG; RO 0094889; THYMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER TISSUE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG SYNTHESIS; ENZYME DEGRADATION; HUMAN; HUMAN TISSUE; NONHUMAN; PROTEIN EXPRESSION;

EID: 0037430550     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)01082-X     Document Type: Article

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