Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643

Journal of Biological Chemistry

Volumn 278, Issue 10, 2003, Pages 8804-8808

  Yang, Zhiru ^a   Savehenko, Alexei ^b   Yakunin, Alexander ^c   Zhang, Rongguang ^d   Edwards, Aled ^b,c   Arrowsmith, Cheryl ^b   Tong, Liang ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; CRYSTAL STRUCTURE; GENES; INTERFACES (MATERIALS); MOLECULAR STRUCTURE;

PROKARYOTES;

ENZYMES;

ASPARTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GENE; BACTERIAL METABOLISM; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; NONHUMAN; NUCLEOTIDE METABOLISM; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; THERMOTOGA MARITIMA; TM1643 GENE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ARCHAEA; BACTERIA (MICROORGANISMS); EUKARYOTA; PROKARYOTA; THERMOTOGA MARITIMA;

AMINO ACID OXIDOREDUCTASES; AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037424378     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211892200     Document Type: Article

References (24)

1. Nelson, K. E., Clayton, R. A., Gill, S. R., Gwinn, M. L., Dodson, R. J., Haft, D. H., Hickey, E. K., Peterson, J. D., Nelson, W. C., Ketchum, K. A., McDonald, L., Utterback, T. R., Malek, J. A., Linher, K. D., Garrett, M. M., Stewart, A. M., Cotton, M. D., Pratt, M. S., Phillips, C. A., Richardson, D., Heidelberg, J., Sutton, G. G., Fleischmann, R. D., Eisen, J. A., and Fraser, C. M., et al. (1999) Nature 399, 323-329
2. Nasu, S., Wicks, F. D., and Gholson, R. K. (1982) J. Biol. Chem. 257, 626-632
3. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
4. Weeks, C. M., and Miller, R. (1999) J. Appl. Crystallogr. 32, 120-124
5. Terwilliger, T. C., and Berendzen, J. (1999) Acta Crystallogr. Sect. D Biol. Crystallogr. 55, 849-861
6. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. Sect. A 47, 110-119
7. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J.-S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 54, 905-921
8. Bergmeyer, H. U. (1985) Methods Enzymol. 8, 454-461
9. Bergmeyer, H. U. (1985) Methods Enzymol. 6, 570-577
10. Yoshida, A., and Freese, E. (1970) Methods Enzymol. 17, 176-181
11. Tedeschi, G., Negri, A., Mortarino, M., Ceciliani, F., Simonic, T., Faotto, L., and Ronchi, S. (1996) Eur. J. Biochem. 239, 427-433
12. Angeles, T. S., and Viola, R. E. (1990) Arch. Biochem. Biophys. 283, 96-101
13. Karsten, W. E., and Viola, R. E. (1991) Biochim. Biophys. Acta 1077, 209-219
14. Wong, Y. H., Mauck, L. A., and Sherman, W. R. (1982) Methods Enzymol. 90, 309-314
15. Hendrickson, W. A. (1991) Science 254, 51-58
16. Holm, L., and Sander, C. (1993) J. Mol. Biol. 233, 123-138
17. Norman, R. A., McAlister, M. S. B., Murray-Rust, J., Movahedzadeh, F., Stoker, N. G., and McDonald, N. Q. (2002) Structure 10, 393-402
18. Scapin, G., Blanchard, J. S., and Sacchettini, J. C. (1995) Biochemistry 34, 3502-3512
19. Hadfield, A., Shammas, C., Kryger, G., Ringe, D., Petsko, G. A., Ouyang, J., and Viola, R. E. (2001) Biochemistry 40, 14475-14483
20. Turnbull, A. P., Baker, P. J., and Rice, D. W. (1997) J. Biol. Chem. 272, 25105-25111
21. Rife, J. E., and Cleland, W. W. (1980) Biochemistry 19, 2328-2333
22. Tally, J. F., Maniscalco, S. J., Saha, S. K., and Fisher, H. F. (2002) Biochemistry 41, 11284-11293
23. Carson, M. (1987) J. Mol. Graphics 5, 103-106
24. Nicholls, A., Sharp, K. A., and Honig, B. (1991) Proteins 11, 281-296