The glutathione system in the human gastrointestinal mucosa: Meaning and influence of clinical factors;Das glutathionsystem im menschlichen gastrointestinaltrakt: Bedeutung und einfluss klinischer faktoren

Deutsche Medizinische Wochenschrift

Volumn 128, Issue 10, 2003, Pages 507-511

  Morgenstern, Ingolf ^a   Kirch, W ^b  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GLYCINE; ISOENZYME;

ADENOMATOUS POLYP; BIOTRANSFORMATION; CANCER RISK; CATALYSIS; COLON MUCOSA; COLORECTAL CANCER; CONJUGATION; CYTOSTASIS; ENZYME ACTIVITY; FAMILIAL DISEASE; GASTROINTESTINAL MUCOSA; GASTROINTESTINAL TRACT; GENOTYPE; GLUTATHIONE METABOLISM; HUMAN; PARAMETER; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW;

GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HUMANS; INTESTINAL MUCOSA; ISOENZYMES; OXIDATION-REDUCTION;

EID: 0037424080     PISSN: 00120472     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-37632     Document Type: Review

References (51)

1. Beil W, Obst B, Sewing KF, Wagner S. Helicobacter pylori reduces intracellular glutathione in gastric epithelial cells. Dig Dis Sci 2000; 45: 1769-1773
2. Bhaskar L, Ramakrishna BS, Balasuhramaniani KA. Colonic mucosal antioxidant enzymes and lipid peroxide levels in normal subject and patients with ulcerative colitis. J Gastroenterol Hepat 1995; 10: 140-143
3. Board P, Coggan M, Johnston P, Ross V, Suzuki T, Webb G. Genetic heterogenity of the human glutathione transferases: A complex of gene families. Pharmacol Ther 1990; 48: 357-369
4. Bogaards JJP, Verhagen H, Willems MI, van Poppel G, van Bladeren PJ. Consumption of brussels sprouts results in elevated (-class glutathione S-transferase levels in human blood plasma. Carcinogenesis 1994; 15: 1073-1075
5. Butler WJ, Ryan P, Roberts-Thomson IC. Metabolic genotypes and risk for colorectal cancer increased risk in individuals with glutathione transferase theta 1 (GSTT1) gene defect. Gastroenterology 1997; 112: A542
6. Clapper ML, Szarka CE, Pfeiffer CR et al. Preclinical and clinical evaluation of broccoli supplements as inducer of glutathione S-transferase activity. Clin Cancer Res 1997; 3: 25-30
7. Clapper ML, Szarka CE. Glutathione S-transferases - biomarkers of cancer risk and chemopreventive response. Chemico-Biological Interactions 1998; 111: 377-388
8. Clapper ML, Hoffmann SJ, Tew KD. Characterization of glutathione S-transferases in human colon carcinomas. Proc Am Ass Cancer Res 1988; 29: 290
9. Cotton SC, Sharp L, Little J, Brockton N. Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE Review. Am J Epidem 2000; 151: 7-31
10. Deakin M, Elder J, Hendricksen C. Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, gastric and colorectal cancers. Carcinogenesis 1996; 17: 881-884
11. Duncan H, Swan C, Green J et al. Susceptibility to ulcerative colitis and Crohn's disease: interactions between glutathione S-transferase GSTM1 und GSTT1 genotypes. Clin Chim Acta 1995; 240: 53-61
12. Gertig DM, Stampfer M, Haimann CH. Glutathione S-transferase GSTM1 und GSTT1 polymorphisms and colorectal cancer risk: a prospective study. Cancer Epidem Biomark Prev 1998; 7: 1001-1005
13. Graham S. Results of case-control studies of diet and cancer in Buffalo, New York. Cancer Res 1983; 43 (Suppl); 2409-2413
14. Grubben MJAL, van den Braak CCM, Peters WHM et al. Low levels of colonic glutathione S-transferase in patients with x-linked agammaglobulinaemia. Eur J Clin Invest 2000; 30: 642-645
15. Guyonnet D, Siess M, Le Bon AM, Suschetet M. Modulation of phase II enzymes by organsulfur compounds from allium vegetables in rat tissues. Toxicol Appl Pharmacol 1999; 154: 50-58
16. Hayes JD, Pulford DJ. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Molecular Biol 1995; 30: 445-600
17. Hertevig E, Nilsson A, Seidegard J. The expression of glutathione transferase (in patients with inflammatory bowel disease. Scand J Gastroenterol 1994; 29: 729-735
18. Hirowaka K, Kawasaki H. Changes in glutathione in gastric mucosa of gastric ulcer patients. Res Commun Mol Pathol Pharmacol 1995; 88: 163-176
19. Hoensch H, Morgenstern I, Petereit G, Roelofs HMJ, Peters WHM, Kirch W. Influence of clinical factors, diet and drugs on the human upper gastrointestinal glutathione system. Gut 2002; 50: 235-240
20. Hoppencamps R, Thies E, Younes M, Siegers CP. Glutathione and glutathione-dependent enzymes in the human gastric mucosa. Klin Wochenschr 1984; 62: 183-186
21. Howie AF, Forrester LM, Glancey MJ et al. Glutathione S-transferase and glutathione peroxidase expression in normal and tumor human tissues. Carcinogenesis 1990; 11: 451-458
22. Inone M, Nobukuni Y, Ando Y, Hirota M, Morino Y. Interorgan metabolism of glutathione as the defence mechanism against oxidative stress. Amsterdam: Elsevier, In: Tanabe T, Hook JB, Endon H, editors. Nephrotoxicity of antibiotics and immunsuppressant. 1986
23. Katoh T, Nagata N, Kuroda Y, Itoh H, Kawahara A, Bell DA. Glutathione S-transferase M1 (GSTM1) und T1 (GSTT1) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma. Carcinogenesis 1996; 17: 1855-1859
24. Lee E, Huang Y, Zhao B, Seow-Choen F, Balakrishnan A, Chan SH. Genetic polymorphism of conjugating enzymes and cancer risk: GSTM1, GSTT1, NAT1 and NAT2. J Toxicol Sci 1998; 23: 140-142
25. Lin HJ, Probst-Hensch NM, Louie AD et al. Glutathione transferase null genotype, broccoli, and lower prevalence of colorectal adenomas. Cancer Epidemiol Biomarkers Prev 1998; 7: 647-652
26. Loguercio C, Taranto D, Vitale LM, Beneduce F, del Vecchio Blanco C. Effect of liver cirrhosis and age on the glutathione concentration in the plasma, erythrocytes and gastric mucosa of man. Free Rad Biol Med 1996; 20: 483-488
27. Mannervik B, Awasthi YC, Board PG. Nomenclature for human glutathione transferases. Biochem J 1992; 282: 305-306
28. Maugard CM, Charrier J, Brignon YJ. Allelic deletion at glutathione S-transferase M1 locus and its association with breast cancer susceptibility. Chem Biol Interact 1998; 111-112: 365-375
29. Michelet F, Gulguen R, Leroy P, Wellman M, Nicolas A, Siest G. Blood and plasma glutathione measured in healthy subjects by HPLC: relation to sex, aging, biological variables and life habits. Clin Chem 1995; 41: 1509-1517
30. Mulder TPJ, Verspaget HW, Sier CFM et al. Glutathione S-transferase pi in colorectal tumors is predictive for overall survival. Cancer Res 1995; 55: 2696-2702
31. Nijhoff WA, Bosboom MA, Smidt MH, Peters WHM. Enhancement of rat hepatic and gastrointestinal glutathione and glutathione S-transferases by α-angelealactone and flavone. Carcinogenesis 1995; 16: 607-612
32. Nijhoff WA, Peters WHM. Quantification of induction of rat oesophageal, gastric and pancreatic glutathione and glutathione S-transferase by dietatry anticarcinogenes. Carcinogenesis 1994; 15: 1769-1772
33. Oijen AH, Verhulst ML, Roelofs HM, Peters WHM, de Boer WA, Jansen JB. Eradication of helicobacter pylori restores glutathione S-transferase activity and glutathione levels in antral mucosa. Jpn J Cancer Res 2001; 92: 1329-1334
34. Peters WHM, Kock L, Nagengast FM, Kemers PG. Biotransformation enzymes in human intestine: critical low levels in the colon. Gut 1991; 32: 408-412
35. Peters WHM, Nagengast FM, van Tongeren JHM. Glutathione S-transferase, cytochrome P450 and uridine 5′-diphosphate-glucuronyltransferase in human small intestine and liver. Gastroenterology 1989; 96: 783-789
36. Peters WHM, Roelofs HMJ, Hectors MPC, Nagengast FM, Jansen JBMJ. Glutathione and glutathione S-transferases in Barrett's epithelium. Br J Cancer 1993; 67: 1413-1417
37. Peters WHM, Roelofs HMJ, Nagengast FM et al. Human intestinal glutathione S-transferases. Biochem J 1989; 257: 471-476
38. Peters WHM, Nagengast FM, Wobbes T. Glutathione S-transferases in normal and cancerous human colon tissue. Carcinogenesis 1989; 10: 2371-1374
39. Schipper DL, Wagenmans MJM, van Haelst U et al. Glutathione S-transferase in gastric carcinomas and in adjacent normal gastric epithelium: Immunohistochemical and biochemical analyses. Anticancer Res 1996; 16: 565-572
40. Shirin H, Pinto JT, Liu LU, Merzianu M, Sordillo EM, Moss SF. Helicobacter pylori decreases gastric mucosal glutathione. Cancer Lett 2001; 164: 127-133
41. Sleisinger MH, Fordtran JS. Gastrointestinal and Liver Disease - Pathophysiology/Diagnosis/Management. 6th edition (Hrsg). Philadelphia: W.B. Saunders Company, 1998
42. Spigelman AD, Nugent KP, Penna C, Foulds S, Phillips RK. Glutathione S-transferase Mu phenotype in patients with familial adenomatous polyposis and in unaffected controls. Cancer Detect Prev 1994; 18: 253-258
43. Strange RC, Matharoo B, Faulder GC et al. The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma. Carcinogenesis 1991; 12: 25-28
44. Szarka CE, Pfeiffer GR, Hum ST et al. Glutathione S-transferase activity and glutathione mu expression in subjects with risk for colorectal cancer. Cancer Res 1995; 55: 2789-2793
45. van Treptow-Lishaut S, Beckemmer G, Rowland I, Dolara P, Pool-Zobel BL. The carbohydrate crystalean and colonic microflora modulate expression of glutathione S-transferase subunits in colon of rats. Eur J Nutr 1999; 38: 76-83
46. Tsuchida S, Sato K. Glutathione transferases and cancer. Crit Rev Biochem Mol Biol 1992; 27: 337-384
47. van Lieshout EMM, Jansen JBMJ, Peters WHM. Biomarkers in Barrett's esophagus. Int J Ocol 1998; 13: 855-864
48. van Lieshout EMM, Peters WHM, Jansen JBMJ. Effect of oltipraze, (-tocopherol, (-carotene and phenethylisothiocyanate on rat oesophageal, gastric, colonic and hepatic glutathione, glutathion S-transferase and peroxidase. Carcinogenesis 1996; 17: 1439-1445
49. van Lieshout EMM, Tiemessen DM, Witteman BJ, Jansen JB, Peters WHM. Low glutathione and glutathione S-transferase levels in Barrrett's esophagus as compared to normal esophageal epithelium. Jpn J Cancer Res 1999; 90: 81-85
50. Witte JS, Longnecker MP, Bird CL, Lee ER, Franke HD, Haile RW. Relation of vegetable, fruit and grain consumption to colorectal adenomatous polyps. Am J Epidemiol 1996; 144: 1015-1027
51. Zhong S, Wyllie AH, Banes D, Wolf CR. Relationship between GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis 1993; 14: 1821-1824