Genetic polymorphism of conjugating enzymes and cancer risk: GSTM1, GSTT1, NAT1 and NAT2

Journal of Toxicological Sciences

Volumn 23, Issue SUPPL. 2, 1998, Pages 140-142

  Lee, Edmund ^a   Huang, Yan ^a   Zhao, Bin ^a   Seow Choen, Francis ^b   Balakrishnan, A ^b   Chan, S H ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; GLUTATHIONE TRANSFERASE;

CANCER RISK; CARCINOGENICITY; COLORECTAL CANCER; CONFERENCE PAPER; CONJUGATION; DETOXIFICATION; GENE MUTATION; GENETIC POLYMORPHISM; NASOPHARYNX CARCINOMA;

EID: 0031881083     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.23.supplementii_140     Document Type: Conference Paper

References (18)

1. Hayes JD, Pulford, DJ. (1995) The glutathione D-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. in Biochem. and Mol Biol., 30, 445-461.
2. Mannervick B, Awasthi YC, Yayes JD et al. (1992) Nomenclature for human glutathione transferase. Biochem J, 282, 305-308.
3. Lin HJ, Ran CY, Berstein DA et al. (1994) Ethnic distribution of the glutathione transferase Mu 1-1 (GST1) null genotype in 1473 individuals and application to bladder cancer susceptibility. Carcinogenesis, 15, 1077-1081.
4. Strange RC, Faulder CG, Davis BA et al. (1984) The human glutathione S-transferase: studies on the tissue distribution and genetic variation of the GST1, GST2 and GST3 isozymes. Ann. Hum. Genet., 48, 11-20.
5. Lee EJD, Zhao B, Moochhala SM et al. (1994) Frequency of mutant CYP1A1, NAT2 and GSTM1 alleles in a normal Chinese population. Pharmacogenetics, 4, 355-358.
6. Hayashi S, Watanabe J, Kawajiri K (1992) High susceptibility of lung cancer analysed in terms of combined genotypes of CYP 1A1 and mu-class glutathione S-transferase genes. Jpn. J. Cancer Res. 83, 866-70.
7. Zhong S, Wyllie AH, Barnes D et al. (1993) Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis, 14, 1821-4.
8. Chenevix-Trench G, Young J, Coggan M et al. (1995) Glutahtione S-transferase M1 and T1 polymorphism: susceptibility to colon cancer and age of onset. Carcinogenesis, 16, 1655-1657.
9. Deaken M, Elder J, Hendrickse C et al. (1996) Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis, 17, 881-884.
10. Lee EJD, Wong JYY, Yeoh PN et al. (1995) Glutathione S-transferase-??(GSTT1) genetic polymorphism among Chinese, Malays and Indians in Singapore. Pharmocogenetics, 5, 332-334.
11. Grant DM (1994) Molecular genetics of the acetyltransferases. 10th International Symposium on Microsomes and Drug Oxidations (Toronto, Canada), Abstract, 12-14.
12. Hein DW (1988) Acetylator genotype and arylamine-induced Carcinogenesis. Biochim. Biophys. Acta 1988, 948, 37-66.
13. Ilett KF, David BM, Detchon P et al. (1987) Acetylation phenotype in colorectal carcinoma. Cancer Res. 47, 1466-1469.
14. Lang NP, Chu DZJ, Hunter CF et al. (1986) Role of aromatic amine acetyltransferase in human colorectal cancer. Arch Surg, 121, 1259-1261.
15. Lee EJD, Zhao B, Moochhala SM et al. (1994) Frequency of CYP1A1, NAT2 and GSTM1 alleles in a normal Chinese population. Pharmacogenetics, 4, 355-358.
16. Shibuta K, Nakashima T, Abe M et al. (1994) Molecular genotyping for N-acetylation polymorphism in Japanese patients with colorectal cancer. Cancer, 74, 3108-3112.
17. Vatsis KP, Martell KJ, Weber WW (1991) Diverse point mutations in the human gene for polymorphic N-acetyltransferase. Proc. Natl. Acad. Sci. USA, 88, 6333-6337.
18. Wohlleb JC, Hunter CF, Blass B et al. (1990) Aromatic amine acetyltransferase as a marker for colorectal cancer: environmental and demographic associations. Int. J. Cancer, 46, 22-30.