Vectorial sodium transport across the mammalian alveolar epithelium: It occurs but through which cells?

Circulation Research

Volumn 92, Issue 4, 2003, Pages 348-349

  Matalon, Sadis ^a,b   Davis, Ian C ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Alveolar fluid clearance; Alveolar type I II cells; Na+,K+ ATPase isoforms; Pulmonary edema; Sodium channels

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ISOENZYME; SODIUM CHANNEL;

CELL TYPE; EDITORIAL; ELECTROPHYSIOLOGY; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG EDEMA; LUNG FLUID; MAMMAL; OXIDATIVE STRESS; PRIORITY JOURNAL; SODIUM TRANSPORT;

ANIMALS; EPITHELIAL CELLS; LUNG; NA(+)-K(+)-EXCHANGING ATPASE; OUABAIN; PULMONARY ALVEOLI; SODIUM;

EID: 0037423811     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000061793.14540.2B     Document Type: Editorial

References (21)

1. Hummler E, Barker P, Gatzy J, Beermann F, Verdumo C, Schmidt A, Boucher R, Rossier BC. Early death due to defective neonatal lung liquid clearance in αENaC-deficient mice. Nat Genet. 1996;12:325-328.
2. Matalon S, O'Brodovich H. Sodium channels in alveolar epithelial cells: molecular characterization, biophysical properties, and physiological significance. Annu Rev Physiol. 1999;61:627-661.
3. Matthay MA, Folkesson HG, Clerici C. Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol Rev. 2002;82:569-600.
4. Yue G, Matalon S. Mechanisms and sequelae of increased alveolar fluid clearance in hyperoxic rats. Am J Physiol. 1997;272(3 pt 1):L407-L412.
5. +-ATPase β1 subunit gene improves alveolar fluid clearance and survival in hyperoxic rats. Hum Gene Ther. 2000;11:2231-2242.
6. Ware LB, Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med. 2001;163:1376-1383.
7. Matthay MA, Wiener-Kronish JP. Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am Rev Respir Dis. 1990;142:1250-1257.
8. Dobbs LG. Isolation and culture of alveolar type II cells. Am J Physiol. 1990;258:L134-L147.
9. Cheek JM, Kim KJ, Crandall ED. Tight monolayers of rat alveolar epithelial cells: bioelectric properties and active sodium transport. Am J Physiol. 1989;256:C688-C693.
10. Yue G, Russell WJ, Benos DJ, Jackson RM, Olman MA, Matalon S. Increased expression and activity of sodium channels in alveolar type II cells of hyperoxic rats. Proc Natl Acad Sci U S A. 1995;92:8418-8422.
11. Jain L, Chen XJ, Ramosevac S, Brown LA, Eaton DC. Expression of highly selective sodium channels in alveolar type II cells is determined by culture conditions. Am J Physiol Lung Cell Mol Physiol. 2001;280:L646-L658.
12. +-ATPase function in A549 cells. Am J Respir Cell Mol Biol. 1998;18:741-749.
13. +-ATPase in rat type II pneumocytes. J Appl Physiol. 1986;60:1584-1589.
14. Ingbar DH, Duvick S, Savick SK, Schellhase DE, Detterding R, Jamieson JD, Shannon JM. Developmental changes of fetal rat lung Na-K-ATPase after maternal treatment with dexamethasone. Am J Physiol. 1997;272(4 pt 1):L665-L672.
15. Johnson MD, Widdicombe JH, Allen L, Barbry P, Dobbs LG. Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis. Proc Natl Acad Sci USA. 2002;99:1966-1971.
16. Ridge KM, Olivera WG, Saldias F, Azzam S, Horowitz S, Rutschman DH, Dumasius V, Factor P, Sznajder JI. Alveolar type 1 cells express the α2 Na,K-ATPase, which contributes to lung liquid clearance. Circ Res. 2003;92:453-460.
17. Nici L, Dowin R, Gilmore-Hebert M, Jamieson JD, Ingbar DH. Upregulation of rat lung Na-K-ATPase during hyperoxic injury. Am J Physiol. 1991;261:L307-L314.
18. Borok Z, Liebler JM, Lubman RL, Foster MJ, Zhou B, Li X, Zabski SM, Kim KJ, Crandall ED. Na transport proteins are expressed by rat alveolar epithelial type I cells. Am J Physiol Lung Cell Mol Physiol. 2002;282:L599-L608.
19. Yue G, Shoemaker RL, Matalon S. Regulation of low-amiloride-affinity sodium channels in alveolar type II cells. Am J Physiol. 1994;267:L94-L100.
20. Factor P, Saldias F, Ridge K, Dumasius V, Zabner J, Jaffe HA, Blanco G, Barnard M, Mercer R, Perrin R, Sznajder JI. Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase β1 subunit gene. J Clin Invest. 1998;102:1421-1430.
21. Thome U, Chen L, Factor P, Dumasius V, Freeman B, Sznajder JI, Matalon S, Na,K-ATPase gene transfer mitigates an oxidant-induced decrease of active sodium transport in rat fetal ATII cells. Am J Respir Cell Mol Biol. 2001;24:245-252.