Rheology, oxygen transfer, and molecular weight characteristics of poly(glutamic acid) fermentation by Bacillus subtilis

Biotechnology and Bioengineering

Volumn 82, Issue 3, 2003, Pages 299-305

  Richard, Andrew ^a   Margaritis, Argyrios ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Bacillus subtilis; Biopolymer pharmaceuticals; Controlled drug delivery; Fermentation; Oxygen transfer; Paclitaxel; Poly(glutamic acid); Rheology

Indexed keywords

BIODEGRADATION; DRUG THERAPY; FERMENTATION; MOLECULAR WEIGHT; ONCOLOGY; RHEOLOGY;

MICROBIAL FERMENTATION;

BIOPOLYMERS;

PACLITAXEL; POLYGLUTAMIC ACID;

ANIMAL CELL; ARTICLE; BACILLUS SUBTILIS; CAPILLARY ENDOTHELIUM; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG TARGETING; ENDOTHELIUM CELL; FERMENTATION; FLOW KINETICS; MOLECULAR WEIGHT; NONHUMAN; OXYGEN TRANSPORT; TUMOR VOLUME;

BACILLUS SUBTILIS; BIOREACTORS; CELL CULTURE TECHNIQUES; MOLECULAR WEIGHT; OXYGEN; OXYGEN CONSUMPTION; POLYGLUTAMIC ACID; RHEOLOGY; SPECIES SPECIFICITY; VISCOSITY;

BACILLUS SUBTILIS;

EID: 0037420745     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10568     Document Type: Article

References (48)

1. La determination in fungal fermentation, taking into account electrode response time. J Chem Technol Biotechnol 75:469-474.
2. Bandyopadhyay B, Humphrey A, Taguchi H. 1967. Dynamic measurement of the volumetric oxygen transfer coefficient in fermentation systems. Biotechnol Bioeng 9:533-544.
3. Casas J, Santos V, Garcia-Ochoa F. 2000. Xanthan gum production under several operating conditions: molecular structure and rheological properties. Enzyme Microbiol Technol 26:282-291.
4. Cell Therapeutics. 2001. Company press releases. www.cticseattle.com. Cell Therapeutics Inc., Seattle, WA.
5. Chemical and Engineering News. 2002. States sue Bristol-Myers over Taxol generics. 80:13.
6. Cromwick A-M, Birrer G, Gross R. 1996. Effects of pH and aeration on γ-poly(glutamic acid) formation by Bacillus licheniformis in controlled batch fermentor cultures. Biotechnol Bioeng 50:222-227.
7. De Leon A, Barba-de la Rosa A, Mayani H, Galindo E, Ramirez O. 2001. Two useful dimensionless parameters that combine physiological, operational and bioreactor design parameters for improved control of dissolved oxygen. Biotechnol Lett 23:1051-1056.
8. Engel J, Deger W, Reissman T, Losse G, Naumann W, Murgas S. 2000. Process for the preparation of immobilized and activity stabilized complexes of LHTH. US Patent 6,054,555.
9. Garcia-Ochoa F, Gomez E, Santos V. 2000. Oxygen transfer and uptake rates during xanthan gum production. Enzyme Microbiol Technol 27:680-690.
10. Giannos S, Gross A, Kaplan D, Mayer J. 1990. Poly(glutamic acid) produced by bacterial fermentation. In: Dawes EA, editor. Novel biodegradable microbial polymers. Dordrecht: Kluwer Academic. p 457-460.
11. Godbole S, Schumpe A, Shah Y, Carr N. 1984. Hydrodynamics and mass transfer in non-Newtonian solutions in a bubble column. AIChEJ 30:213-220.
12. Goto A, Kunioka M. 1992. Biosynthesis and hydrolysis of poly(γ-glutamic acid) from Bacillus subtilis IFO3335. Biosci Biotech Biochem 56:1031-1035.
13. Gross A. 1998. Bacterial γ-poly(glutamic acid). In: Kaplan DL, editor. Biopolymers from renewable resources. New York: Springer. p 195-219.
14. Hannote M, Flores F, Torres L, Galindo E. 1991. Apparent yield stress estimation in xanthan gum solutions and fermentation broths using a low-cost viscometer. Chem Eng J 45:B49-B56.
15. Hasegawa S, Nagatsuri M, Shibutani M, Yamamoto S, Hasebe S. 1999. Productivity of concentrated hyaluronic acid using a Maxblend® fermentor. J Biosci Bioeng 88:68-71.
16. Hwan Do J, Chang H, Lee S. 2001. Efficient recovery of poly(glutamic acid) from highly viscous culture broth. Biotechnol Bioeng 76:219-223.
17. Iwata H, Matsuda S, Mitsuhashi K, Kenji I, Itoh E, Ikada Y. 1998. A novel surgical glue composed of gelatin and N-hydroxysuccinimide activated poly(L-glutamic acid). Biomaterials 19:1869-1876.
18. Kawase Y, Hashimoto N. 1996. Gas hold-up and oxygen transfer in threephase external-loop airlift bioreactors: non-Newtonian fermentation broths. J Chem Tech Biotechnol 65:325-334.
19. King E, Blacker A, Bugg T. 2000. Enzymatic breakdown of poly-γ-Dglutamic acid in Bacillus licheniformis: identification of a polyglutamyl-γ-hydrolase enzyme. Biomacromolecules 1:75-83.
20. Ko Y, Gross R. 1998. Effects of glucose and glycerol on γ-poly(glutamic acid) formation by Bacillus licheniformis ATCC 9945a. Biotechnol Bioeng 57:430-437.
21. Kubota H, Matsunobu T, Uotani K, Takebe H, Satoh A, Tanaka T, Taniguchi M. 1993. Production of Poly(γ-glutamic acid) by Bacillus subtilis F-2-01. Biosci. Biotech Biochem 57:1212-1213.
22. Kubota H, Nambu Y, Endo T. 1996. Alkaline hydrolysis of poly(γglutamic acid) produced by microorganism. J Pol Sci A Polymer Chem 34:1347-1351.
23. Kunioka M, Goto A. 1994. Biosynthesis of poly(γ-glutamic acid) from L-glutamic acid, citric acid, and ammonium sulfate in Bacillus subtilis IFO3335. Appl Microbiol Biotechnol 40:867-872.
24. Landon R, Law C, Webb C. 1993. Fermentation broth rheology during dextran production by Leuconostoc mesenteroides B512(F) as a possible tool for control. Appl Microbiol Biotechnol 40:251-257.
25. Lee I, Kim M, Lee J, Jung J, Lee H, Pary Y, Seo W. 1999. Influence of agitation speed on production of curdlan by Agrobacterium species. Bioproc Eng 20:283-287.
26. Leonard C, Housewright R, Thorne C. 1958. Effects of some metallic ions on glutamyl polypeptide synthesis by Bacillus subtilis. J Bacteriol 76:499-503.
27. Li C, Wallace S, Yu D-F, Yang D. 1999. Water soluble paclitaxel prodrugs. US Patent 5,977,163.
28. Li C, Ke S, Wu Q-P, Tansey W, Hunter N, Buchmiller L, Milas L, Chamsangavej C, Wallace S. 2000. Experimental therapeutics, preclinical pharmacology - tumor irradiation enhances the tumor-specific distribution of poly(L-glutamic acid)-conjugated paclitaxel and its antitumor efficacy. Clin Cancer Res 6:2829-2834.
29. Lopez E, Gomez E. 1996. Simultaneous determination of the major organic acids, sugars, glycerol and ethanol by HPLC in grape musts and white wines. J Chromatogr 34:254-257.
30. Margaritis A, Pace G. 1985. Microbial polysaccharides. In: Blanch H, Drew S, Wang D, editors. Comprehensive biotechnology, vol. 3. The principles, applications and regulations of biotechnology in industry, agriculture and medicine. Oxford: Pergamon Press. p 1005-1044.
31. Margaritis A, Zajic J. 1978. Mixing, mass transfer and scale-up of polysaccharide fermentations. Biotechnol Bioeng 20:939-1001.
32. Moo-Young M, Halard B, Allen D, Burrell R, Kawase Y. 1987. Oxygen transfer to mycelial fermentation broths in an airlift fermentor. Biotechnol Bioeng 30:746-753.
33. Moore S. 1968. Amino acid analysis: aqueous dimethyl sulfoxide as solvent for the ninhydrin reaction. J Biol Chem 243:6281-6283.
34. Multani A, Li C, Ozen M, Yadav M, Yuu D-F, Wallace S, Pathak S. 1997. Paclitaxel and water-soluble poly(L-glutamic acid)-paclitaxel, induce direct chromosomal abnormalities and cell death in a murrine metastatic melanoma cell line. Anticancer Res 17:4269-4274.
35. Myers A, Bichon D. 1992. Cytotoxic drug conjugates and their delivery to tumor cells. US Patent 5,087,616.
36. Otani Y, Tabata Y, Ikada Y. 1996. A new biological glue from gelatin and poly(L-glutamic acid). J Biomed Mat Res 31:157-165.
37. Otani Y, Tabata Y, Ikada Y. 1999. Sealing effect of rapidly curable gelatinpoly(L-glutamic acid) hydrogel glue on lung air leak. Ann Thorac Surg 67:922-926.
38. Ozturk S, Schumpe A. 1987. The influence of suspended solids on oxygen transfer to organic liquids in a bubble column. Chem Eng Sci 42:1781-1785.
39. Richard A, Margaritis A. 2001. Poly(glutamic acid) for biomedical applications. Crit Rev Biotechnol 21:219-232.
40. Roukas T, Mantzouridou F. 2001. Effect of the aeration rate on pullulan production and fermentation broth rheology in an airlift reactor. J Chem Tech Biotechnol 76:371-376.
41. Sakurai Y, Okano T, Kataoka K, Yamada N, Inoue S, Yokoyama M. 1997. Water soluble high molecular weight polymerized drug preparation. US Patent 5,693,751.
42. Scragg AH. 1991. Bioreactors in biotechnology: a practical approach. New York: Ellis Horwood. p 88-110.
43. Sgouras D, Duncan R. 1994. Evaluation of poly(glutamic acid, alanine, tyrosine) (1:1:1) as a lung-specific drug delivery system. I. Biocompatibility and studies on biodistribution in the rat. STP Pharma Sci 4:87-94.
44. Stanbury PF, Whitaker A, Hall SJ. 1995. Principles of fermentation technology, 2nd ed. New York: Pergamon. p 243-276.
45. Van't Riet K, Tramper J. 1991. Basic bioreactor design. New York: Marcel Dekker. p 236-273.
46. Werner F, Mersmann A. 1998a. Part 1: a simple method for testing the consistency of data sets for the description of the rheology of polymer solutions. Chem Eng Technol 7:644-647.
47. Werner F, Mersmann A. 1998b. Part 2: a simple method for testing the consistency of data sets for the description of the rheology of polymer solutions. Chem Eng Technol 7:559-562.
48. Yoon S, Do J, Lee S, Chang H. 2000. Production of poly-γ-glutamic acid by fed-batch culture of Bacillus licheniformis. Biotechnol Lett 22:585-588.