Betulin isolation from birch bark by vacuum and atmospheric sublimation. A thermogravimetric study

Thermochimica Acta

Volumn 398, Issue 1-2, 2003, Pages 153-166

  Guidoin, Marie France ^a   Yang, Jin ^a   Pichette, André ^b   Roy, Christian ^a,c  

^a UNIVERSITÉ LAVAL   (Canada)

^b UNIVERSITÉ DU QUÉBEC À CHICOUTIMI   (Canada)

^c Institut Pyrovac Inc   (Canada)

Author keywords

Betulin isolation; Birch bark; Sublimation; Thermogravimetry

Indexed keywords

BETULIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ATMOSPHERIC PRESSURE; BARK; DIFFERENTIAL SCANNING CALORIMETRY; DRUG STRUCTURE; DRUG SYNTHESIS; POLYMERIZATION; STRUCTURE ANALYSIS; TEMPERATURE DEPENDENCE; THERMOGRAVIMETRY;

EID: 0037420059     PISSN: 00406031     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-6031(02)00358-1     Document Type: Article

References (15)

1. E. Pisha, H. Chai, T.E. Chagwedera, N.R. Farnsworth, G.A. Cordell, Nat. Med. 1 (1995) 1046.
2. D.S.H.L. Kim, Z. Chen, V.T. Nguyen, J.M. Pezzuto, S. Qiu, Z.Z. Lu, Synth. Commun. 27 (1997) 1607.
3. S. Fulda, I. Jeremias, H.H. Steiner, T. Pietsch, K.M. Debation, Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells, Int. J. Cancer 82 (1999) 435.
4. M. Evers, C. Poujade, F. Soler, Y. Ribeill, C. James, Y. Lelièvre, J.C. Guegen, D. Reisdorf, I. Morize, R. Pauwels, E. De Clercq, Y. Hénin, A. Bousseau, J.E Mayaux, J.B. Le Pecq, N. Dereu, J. Med. Chem. 39 (1996) 1056.
5. Y. Kashiwada, F. Hashimoto, L.M. Cosentino, C.H. Chen, P.E. Garrett, K.H. Lee, J. Med. Chem. 39 (1996) 1016.
6. C. Eckerman, R. Ekman, Paperi ja Puu 3 (1985) 100.
7. H. Fuchino, S. Konishi, H. Imai, H. Wada, N. Tanaka, Chem. Pharm. Bull. 42 (1994) 379.
8. P. Jääskeläinen, Betulinol and its utilisation, Paperi ja Puu 10 (1981) 599.
9. L. Kudela, M.J. Sampson, Sublimation technology, in: J.M. John (Ed.), Encyclopedia of Chemical Processing and Design, Vol. 55, Marcel Dekker, New York, 1996, pp. 224-237.
10. J.P. Elder, Sublimation measurements of pharmaceutical compounds by isothermal thermogravimetry, J. Therm. Anal. 49 (1997) 897.
11. M. Tesconi, M.J. Pikal, S.H. Yalkowsky, A Method for the rapid estimation of sublimation rates of organic compounds at standard temperature and pressure, J. Pharm. Sci. 86 (1997) 1299.
12. E.G. Gillan, S.G. Bott, A.R. Barron, Chem. Mater. 9 (1997) 796.
13. M.F. Guidoin, Isolation du bétulinol de l'écorce de bouleau à papier (Betula Papyfera), M.Sc. Thesis, Université Laval, Sainte-Foy, 2000.
14. C. Roy, B. de Caumia, P. Plante, H. Ménard, Production of liquids from biomass by vacuum pyrolysis development of data base for continuous process, in: Proceedings of the Energy from Biomass and Wastes VII, IGT Symposium, Lake Buena Vista, FL, 24-28 January 1983, pp. 1147-1170.
15. J.N. Murwanashyaka, Séparation et purification du 2,6-diméthoxyphénol, du 4-méthylgaiacol, du catéchol et du méthylcyclopentonolone à partir de l'huile pyrolytique provenant de l'écorce de bouleau à papier (Belula papyrifera), Ph.D. Thesis, Université Laval, Sainte-Foy, 2000 (in French).