Inhibition aspects of the bioconversion of L-phenylalanine to 2-phenylethanol by Saccharomyces cerevisiae

Enzyme and Microbial Technology

Volumn 32, Issue 2, 2003, Pages 212-223

  Stark, D ^a   Zala, D ^a   Munch T ^b   Sonnleitner, B ^c   Marison, I W ^a   Von Stockar, Urs ^a  

^a EPFL   (Switzerland)

^b GIVAUDAN SCHWEIZ AG   (Switzerland)

^c ZURICH UNIVERSITY OF APPLIED SCIENCES   (Switzerland)

Author keywords

2 Phenylethanol; Inhibition kinetics; L Phenylalanine; Metabolic uncoupling; Saccharomyces cerevisiae

Indexed keywords

BIOCONVERSION; ENZYMES; ETHANOL;

CHEMOSTAT CULTURES; RESPIRATORY CAPACITIES;

MICROBIOLOGY;

ALCOHOL; AROMATIC COMPOUND; GLUCOSE; PHENETHYL ALCOHOL; PHENYLALANINE;

ARTICLE; BACTERIAL METABOLISM; BACTERIUM CULTURE; BIOSYNTHESIS; BIOTRANSFORMATION; CATABOLISM; CHEMOSTAT; CONTROLLED STUDY; NONHUMAN; OXIDATION; SACCHAROMYCES CEREVISIAE;

PISUM SATIVUM; SACCHAROMYCES CEREVISIAE;

EID: 0037415346     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0141-0229(02)00237-5     Document Type: Article

References (36)

1. Krings U., Berger R.G. Biotechnological production of flavors and fragrances. Appl. Microbiol. Biotechnol. 49:1998;1-8.
2. Fabre C.E., Blanc P.J., Goma G. 2-Phenylethyl alcohol: an aroma profil. Perfumer Flavorist. 23:1998;43-45.
3. Cheetham P.S.J. The use of biotransformations for the production of flavors and fragrances. TIBTECH. 11:1993;478-488.
4. Sentheshanmuganathan S. The mechanism of the formation of higher alcohols from amino acids by Saccharomyces cerevisiae. Biochem. J. 74:1960;568-576.
5. Kockova-Kratochvilova A. Yeasts and yeast-like organisms. Weinheim: VCH; 1990, p. 381-91.
6. Vollbrecht D., Radler F. Formation of higher alcohols by amino acid deficient mutants of Saccharomyces cerevisiae. I. The decomposition of amino acids to higher alcohols. Arch. Mikrobiol. 94:1973;351-358.
7. Albertazzi E., Cardillo R., Servi S., Zucchi G. Biogeneration of 2-phenylethanol and 2-phenylethy-lacetate important aroma components. Biotechnol. Lett. 16:1994;491-496.
8. Fabre C.E., Blanc P.J., Goma G. Production of 2-phenylethyl alcohol by Kluyveromyces marxianus. Biotechnol. Prog. 14:1998;270-274.
9. Wilson J.R.J., Lyall J., McBride R.J., Murray J.B., Smith G. Partition coefficients of some aromatic alcohols in an n-heptane/water system and their relationship to minimum inhibitory concentration against Pseudomonas aeruginosa and Staphylococcus aureus. J. Clin. Hosp. Pharm. 6:1981;63-66.
10. Lester G. Inhibition of growth, synthesis, and permeability in Neurospora crassa by phenethyl alcohol. J. Bacteriol. 90:1965;29-37.
11. Wilkie D., Maroudas N.G. Induction of cytoplasmic respiratory deficiency in yeast by phenethyl alcohol. Genet. Res. 13:1969;107-111.
12. Ingram L., Buttke T.M. Effects of alcohols on micro-organisms. Adv. Microb. Physiol. 25:1984;254-300.
13. Lucchini J.J., Bonnaveiro N., Cremieux A., Legoffic F. Mechanism of bactericidal action of phenethyl alcohol in Escherichia coli. Curr. Microbiol. 27:1993;295-300.
14. Seward R., Willetts J.C., Dinsdale M.G., Lloyd D. The effects of ethanol, hexan-1-ol, and 2-phenylethanol on cider yeast growth, viability, and energy status: synergistic inhibition. J. Inst. Brew. 102:1996;439-443.
15. Lucchini J.J., Corre J., Cremieux A. Antibacterial activity of phenolic compounds and aromatic alcohols. Res. Microbiol. 141:1990;499-510.
16. Yamané T., Shimizu S. Fed-batch techniques in microbial processes. Adv. Biochem. Eng. Biotechnol. 30:1984;147-194.
17. Casey G.P., Ingledew W.M. Ethanol tolerance in yeasts. Crit. Rev. Microbiol. 13:1986;219-280.
18. Holzberg I., Finn R.K., Steinkraus K.H. A kinetic study of the alcoholic fermentation of grape juice. Biotechnol. Bioeng. 9:1967;413-427.
19. Bazua C.D., Wilke C.R. Ethanol effects on the kinetics of a continuous fermentation with Saccharomyces cerevisiae. Biotechnol. Bioeng. 7:1977;105-118.
20. Luong J.H.T. Kinetics of ethanol inhibition in alcohol fermentation. Biotechnol. Bioeng. 27:1985;280-285.
21. Maiorella B., Blanch H.W., Wilke C.R. By-product inhibition effects on ethanolic fermentation by Saccharomyces cerevisiae. Biotechnol. Bioeng. 15:1983;103-121.
22. Leao C., van Uden N. Effects of ethanol and other alkanols on passive proton influx in the yeast Saccharomyces cerevisiae. Biochim. Biophys. Acta. 774:1984;43-48.
23. Cartwright C.P., Juroszek J.R., Beavan M.J., Ruby F.M.S., Morais S.M.F., Rose A.H. Ethanol dissipates the proton-motive force across the plasma membrane of Saccharomyces cerevisiae. J. Gen. Microbiol. 132:1986;369-377.
24. Terenzi H.F., Storck R. Stimulation by phenethyl alcohol of aerobic fermentation in Mucor rouxii. Biochem. Biophys. Res. Commun. 30:1968;447-452.
25. Postma E., Verduyn C., Scheffers W.A., van Dijken J.P. Enzymic analysis of the Crabtree effect in glucose-limited chemostat cultures of Saccharomyces cerevisiae. Appl. Environ. Microbiol. 55:1989;468-477.
26. Verduyn C., Postma E., Scheffers W.A., van Dijken J.P. Effect of benzoic acid on metabolic fluxes in yeasts: a continuous-culture study on the regulation of respiration and alcoholic fermentation. Yeast. 8:1992;501-517.
27. Verduyn C. Physiology of yeasts in relation to biomass yields. Ph.D. Thesis, TU Delft; 1991.
28. Sonnleitner B., Hahnemann U. Dynamics of the respiratory bottleneck of Saccharomyces cerevisiae. J. Biotechnol. 38:1994;63-79.
29. Pham H.T.B., Larsson G., Enfors S.O. Growth and energy metabolism in aerobic fed-batch cultures of Saccharomyces cerevisiae: simulation and model verification. Biotechnol. Bioeng. 60:1998;474-482.
30. Large P.J. Degradation of organic nitrogen compounds by yeasts. Yeast. 2:1986;1-34.
31. Sparnins V.L., Burbee D.G., Dagley S. Catabolism of L-tyrosine in Trichosporon cutaneum. J. Bacteriol. 138:1979;425.
32. Kron S.J., Styles C.A., Fink G.R. Symmetrical cell division in pseudohyphae of the yeast Saccharomyces cerevisiae. Mol. Biol. Cell. 5:1994;1003-1022.
33. Dickinson J.R. Fusel alcohols induce hyphal-like extensions and pseudohyphal formation in yeasts. Microbiol. (UK). 142:1996;1391-1397.
34. Kuriyama H., Slaughter J.C. Control of cell morphology of the yeast Saccharomyces cerevisiae by nutrient limitation in continuous culture. Lett. Appl. Microbiol. 20:1995;37-40.
35. Wright R.M., Repine T., Repine J.E. Reversible pseudohyphal growth in haploid Saccharomyces cerevisiae is an aerobic process. Curr. Genet. 23:1993;388-391.
36. Freeman A., Woodley J.M., Lilly M.D. In situ product removal as a tool for bioprocessing. Bio/Technology. 11:1993;1007-1012.