Studies on mimicry of naturally occurring annonaceous acetogenins: Non-THF analogues leading to remarkable selective cytotoxicity against human tumor cells

Chemistry - A European Journal

Volumn 9, Issue 1, 2003, Pages 282-290

  Zeng, Bu Bing ^a   Wu, Yikang ^a   Jiang, Sheng ^a   Yu, Qian ^a   Yao, Zhu Jun ^a   Liu, Zhong Hai ^b   Li, Hong Yan ^b   Li, Yan ^b   Chen, Xiao Guang ^b   Wu, Yu Lin ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Annonaceous acetogenins; Asymmetric synthesis; Cytotoxicity; Natural products; Structure activity relationships

Indexed keywords

CYTOLOGY; ORGANIC ACIDS; TOXICITY; TUMORS;

ANNONACEOUS ACETOGENINS;

GENETIC ENGINEERING;

2,5 DIHYDRO 3 (13,19 DIHYDROXY 15,17 DIOXAOCTACOSAN 1 YL) 5 METHYLFURAN 2 ONE; 2,5-DIHYDRO-3-(13,19-DIHYDROXY-15,17-DIOXAOCTACOSAN-1-YL)-5-METHYLFURAN-2-ONE; ACETOGENIN; ACETOGENIN DERIVATIVE; ANTINEOPLASTIC AGENT; ASCORBIC ACID; BUTENOLIDE; DRUG DERIVATIVE; GAMMA BUTYROLACTONE; LACTIC ACID; MANNITOL; NATURAL PRODUCT; THYMUS HORMONE; UNCLASSIFIED DRUG;

ANIMAL; ANNONACEAE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOCHEMISTRY; CELL CULTURE; CELL DIFFERENTIATION; CHEMISTRY; CHIRALITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; METHODOLOGY; MOLECULAR MIMICRY; MOUSE; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING; TUMOR CELL CULTURE;

4-BUTYROLACTONE; ANIMALS; ANNONACEAE; ANTINEOPLASTIC AGENTS; BIOCHEMISTRY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; MOLECULAR MIMICRY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THYMUS HORMONES; TOXICITY TESTS; TUMOR CELLS, CULTURED;

EID: 0037415097     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/chem.200390021     Document Type: Article

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