An AU-rich element in the 3′ untranslated region of the C/EBPδ mRNA is important for protein binding during G0 growth arrest

Biochemical and Biophysical Research Communications

Volumn 304, Issue 2, 2003, Pages 344-350

  Dearth, Lawrence R ^a   DeWille, James ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

AU rich element; CCAAT enhancer binding protein; G0 growth arrest; Mammary epithelial cells; mRNA stability; Untranslated region

Indexed keywords

ADENOSINE; CCAAT ENHANCER BINDING PROTEIN; CIS ACTING ELEMENT; MESSENGER RNA; TRANS ACTING FACTOR; URIDINE;

3' UNTRANSLATED REGION; ANALYTIC METHOD; ANIMAL CELL; ARTICLE; BREAST EPITHELIUM; CELL CYCLE G0 PHASE; CELL GROWTH; CONTROLLED STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RNA ELECTROMOBILITY SHIFT ASSASY;

EID: 0037414462     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00597-7     Document Type: Article

References (41)

1. Ross J. mRNA stability in mammalian cells. Microbiol. Rev. 59:1995;423-450.
2. Ross J. Control of messenger RNA stability in higher eukaryotes. Trends Genet. 12:1996;171-175.
3. Guhaniyogi J., Brewer G. Regulation of mRNA stability in mammalian cells. Gene. 265:2001;11-23.
4. ′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation Cell. 46:1986;659-667.
5. Chen C.Y., Shyu A.B. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 20:1995;465-470.
6. Chen C.Y., Xu N., Shyu A.B. mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation. Mol. Cell. Biol. 15:1995;5777-5788.
7. ′ untranslated region of epidermal growth factor receptor mRNA that is the target for regulated RNA-binding proteins Mol. Cell. Biol. 21:2001;2070-2084.
8. Chen C.Y., Chen T.M., Shyu A.B. Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function. Mol. Cell. Biol. 14:1994;416-426.
9. ′ untranslated region of c-fos mRNA may be involved in the first step of c-fos mRNA degradation Mol. Cell. Biol. 12:1992;2931-2940.
10. Chen C.Y., Shyu A.B. Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements. Mol. Cell. Biol. 14:1994;8471-8482.
11. Malter J.S. Identification of an AUUUA-specific messenger RNA binding protein. Science. 246:1989;664-666.
12. Brewer G. An A. + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro Mol. Cell. Biol. 11:1991;2460-2466.
13. Wilson G.M., Brewer G. The search for trans-acting factors controlling messenger RNA decay. Prog. Nucleic Acid Res. Mol. Biol. 62:1999;257-291.
14. Lapucci A., Donnini M., Papucci L., Witort E., Tempestini A., Bevilacqua A., Nicolin A., Brewer G., Schiavone N., Capaccioli S. AUF1 Is a bcl-2 A. + U-rich element-binding protein involved in bcl-2 mRNA destabilization during apoptosis J. Biol. Chem. 277:2002;16139-16146.
15. Lai W.S., Kennington E.A., Blackshear P.J. Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs. J. Biol. Chem. 277:2002;9606-9613.
16. Lai W.S., Blackshear P.J. Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail. J. Biol. Chem. 276:2001;23144-23154.
17. Lai W.S., Carballo E., Thorn J.M., Kennington E.A., Blackshear P.J. Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA. J. Biol. Chem. 275:2000;17827-17837.
18. Carballo E., Lai W.S., Blackshear P.J. Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability. Blood. 95:2000;1891-1899.
19. Lai W.S., Carballo E., Strum J.R., Kennington E.A., Phillips R.S., Blackshear P.J. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol. Cell. Biol. 19:1999;4311-4323.
20. Taylor G.A., Carballo E., Lee D.M., Lai W.S., Thompson M.J., Patel D.D., Schenkman D.I., Gilkeson G.S., Broxmeyer H.E., Haynes B.F., Blackshear P.J. A pathogenetic role for TNFα in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity. 4:1996;445-454.
21. O'Rourke J., Yuan R., DeWille J. CCAAT/enhancer-binding protein-delta (C/EBP-δ) is induced in growth-arrested mouse mammary epithelial cells. J. Biol. Chem. 272:1997;6291-6296.
22. O'Rourke J.P., Hutt J.A., DeWille J. Transcriptional regulation of C/EBPδ in G(0) growth-arrested mouse mammary epithelial cells. Biochem. Biophys. Res. Commun. 262:1999;696-701.
23. 0 growth arrest and apoptosis J. Biol. Chem. 274:1999;16582-16589.
24. Gigliotti A.P., DeWille J.W. Local signals induce CCAAT/enhancer binding protein-delta (C/EBP-δ) and C/EBP-β mRNA expression in the involuting mouse mammary gland. Breast Cancer Res. Treat. 58:1999;57-58.
25. Gigliotti A.P., DeWille J.W. Lactation status influences expression of CCAAT/enhancer binding protein isoform mRNA in the mouse mammary gland. J. Cell. Physiol. 174:1998;232-239.
26. 0 growth-arrested mouse mammary epithelial cells and in involuting mouse mammary gland J. Biol. Chem. 275:2000;29123-29131.
27. Hurst H.C. Transcription factors. 1: bZIP proteins. Protein Profile. 1:1994;123-168.
28. Lekstrom-Himes J., Xanthopoulos K.G. Biological role of the CCAAT/enhancer-binding protein family of transcription factors. J. Biol. Chem. 273:1998;28545-28548.
29. Ramji D.P., Foka P. CCAAT/enhancer binding proteins: structure, function and regulation. Biochem. J. 365:2002;561-575.
30. Cao Z., Umek R.M., McKnight S.L. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5:1991;1538-1552.
31. Ron D., Habener J.F. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 6:1992;439-453.
32. Robinson G.W., Johnson P.F., Hennighausen L., Sterneck E. The C/EBPβ transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland. Genes Dev. 12:1998;1907-1916.
33. Sterneck E., Tessarollo L., Johnson P.F. An essential role for C/EBPβ in female reproduction. Genes Dev. 11:1997;2153-2162.
34. Seagroves T.N., Lydon J.P., Hovey R.C., Vonderhaar B.K., Rosen J.M. C/EBPβ (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development. Mol. Endocrinol. 14:2000;359-368.
35. Seagroves T.N., Krnacik S., Raught B., Gay J., Burgess-Beusse B., Darlington G.J., Rosen J.M. C/EBPβ, but not C/EBPα, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. Genes Dev. 12:1998;1917-1928.
36. Tang Q.Q., Otto T.C., Lane M.D. CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis. Proc. Natl. Acad. Sci. USA. 100:2003;850-855.
37. Tang Q.Q., Otto T.C., Lane M.D. Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc. Natl. Acad. Sci. USA. 100:2003;44-49.
38. Lane M.D., Tang Q.Q., Jiang M.S. Role of the CCAAT enhancer binding proteins (C/EBPs) in adipocyte differentiation. Biochem. Biophys. Res. Commun. 266:1999;677-683.
39. 0 growth arrested mammary epithelial cells J. Biol. Chem. 278:2003;11246-11255.
40. Ford H.L., Pardee A.B. Cancer and the cell cycle. J. Cell. Biochem. Suppl. 32-33:1999;166-172.
41. Myer V.E., Fan X.C., Steitz J.A. Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay. EMBO J. 16:1997;2130-2139.