PBX1 nuclear export is regulated independently of PBX-MEINOX interaction by PKA phosphorylation of the PBC-B domain

EMBO Journal

Volumn 22, Issue 1, 2003, Pages 89-99

  Kilstrup Nielsen, Charlotte ^a,d   Alessio, Massimo ^b   Zappavigna, Vincenzo ^a,c  

^a Ctr of Cell and Molec Pharmacol   (Italy)

^b Proteomics Laboratory   (Italy)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^d UNIVERSITY OF INSUBRIA   (Italy)

Author keywords

Homeodomain; Limb patterning; Nuclear export; Nuclear import; Post translational regulation

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; GENE PRODUCT; HOMEODOMAIN PROTEIN; NUCLEAR PROTEIN; PROTEIN MEINOX; PROTEIN SERINE THREONINE KINASE; SERINE; TRANSCRIPTION FACTOR PBX1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVATION; MESENCHYME; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT;

3T3 CELLS; ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; HUMANS; ISOELECTRIC FOCUSING; KINETICS; LEUCINE; MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTHREONINE; PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0037413691     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg010     Document Type: Article

References (32)

1. Abu-Shaar, M. and Mann, R.S. (1998) Generation of multiple antagonistic domains along the proximodistal axis during Drosophila development. Development, 125, 3821-3830.
2. Abu-Shaar, M., Ryoo, H.D. and Mann, R.S. (1999) Control of the nuclear localization of Extradenticle by competing nuclear import and export signals. Genes Dev., 13, 935-945.
3. Affolter, M., Marty, T. and Vigano, M.A. (1999) Balancing import and export in development. Genes Dev., 13, 913-915.
4. Askjaer, P. et al. (1999) RanGTP-regulated interactions of CRMI with nucleoporins and a shuttling DEAD-box helicase. Mol. Cell. Biol., 19, 6276-6285.
5. Berthelsen, J., Zappavigna, V., Mavilio, F. and Blasi, F. (1998) Prepl, a novel functional partner of Pbx proteins. EMBO J., 17, 1423-1433.
6. Berthelsen, J., Kilstrup-Nielsen, C., Blasi, F., Mavilio, F. and Zappavigna, V. (1999) The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. Genes Dev., 13, 946-953.
7. Blom, N., Gammeltoft, S. and Brunak, S. (1999) Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J. Mol. Biol., 294, 1351-1362.
8. Bürglin, T.R. (1997) Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved betwen plants and animals. Nucleic Acids Res., 25, 4173-4180.
9. Capdevilla, J., Tsukui, T., Rodrigues Esteban, C., Zappavigna, V. and Izpisua Belmonte, J.C. (1999) Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. Mol. Cell, 4, 839-849.
10. Casares, F. and Mann, R.S. (1998) Control of antennal versus leg development in Drosophila. Nature, 392, 723-726.
11. Chang, C.-P., Jacobs, Y., Nakamura, T., Jenkins, N.A., Copeland, N.G. and Cleary, M.L. (1997) Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol. Cell. Biol., 17, 5679-5687.
12. Chiang, C., Litingtung, Y., Lee, E., Young, K.E., Corden, J.L., Westphal, H. and Beachy, P.A. (1996) Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature, 383, 407-413.
13. Cusella-De Angelis, M.G., Molinari, S., Le Donne, A., Coletta, M., Vivarelli, E., Bouche, M., Molinaro, M., Ferrari, S. and Cossu, G. (1994) Differential response of embryonic and fetal myoblasts to TGF β: a possible regulatory mechanism of skeletal muscle histogenesis. Development, 120, 925-933.
14. Demidenko, Z., Badenhorst, P., Jones, T., Bi, X. and Mortin, M.A. (2001) Regulated nuclear export of the homeodomain transcription factor Prospero. Development, 128, 1359-1367.
15. Diaz-Benjumea, F.J., Cohen, B. and Cohen, S.M. (1994) Cell interaction between compartments establishes the proximal-distal axis of Drosophila legs. Nature, 372, 175-179.
16. Falquet, L., Pagni, M., Bucher, P., Hulo, N., Sigrist, C.J., Hofmann, K. and Bairoch, A. (2002) The PROSITE database, its status in 2002. Nucleic Acids Res., 30, 235-238.
17. Fognani, C., Kilstrup-Nielsen, C., Berthelsen, J., Ferretti, E., Zappavigna, V. and Blasi, F. (2002) Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors. Nucleic Acids Res., 30, 2043-2051.
18. Gonzales-Crespo, S. and Morata, G. (1996) Genetic evidence for the subdivision of the arthropod limb into coxopodite and telopodite. Development, 122, 3921-3928.
19. Gonzales-Crespo, S., Abu-Shaar, M., Torres, M., Martinez-A., C., Mann, R.S. and Morata, G. (1998) Antagonism between extradenticle function and Hedgehog signalling in the developing limb. Nature, 394, 196-200.
20. Hamburger, V. and Hamilton, H.L. (1992) A series of normal stages in the development of the chick embryo. 1951. Dev. Dyn., 195, 231-272.
21. Ingham, P.W. and McMahon, A.P. (2001) Hedgehog signaling in animal development: paradigms and principles. Genes Dev., 15, 3059-3087.
22. Mann, R.S. and Affolter, M. (1998) Hox proteins meet more partners. Curr. Opin. Genet. Dev., 8, 423-429.
23. Mattaj, I.W. and Englmeier, L. (1998) Nucleocytoplasmic transport: the soluble phase. Annu. Rev. Biochem., 67, 265-306.
24. Mercader, N., Leonardo, E., Azpiazu, N., Serrano, A., Morata, G., Martinez-A, C. and Torres, M. (1999) Conserved regulation of proximodistal limb axis development by Meis1/HTH. Nature, 402, 425-429.
25. Morata, G. (2001) How Drosophila appendages develop. Nat. Rev. Mol. Cell Biol., 2, 89-97.
26. Pöpperl, H., Rikhof, H., Chang, H., Haffter, P., Kimmel, C.B. and Moens, C.B. (2000) lazarus is a novel pbx gene that globally mediates hox gene function in zebrafish. Mol. Cell, 6, 255-267.
27. Rieckhof, G.E., Casares, F., Ryoo, H.D., Abu-Shaar, M. and Mann, R.S. (1997) Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein. Cell, 91, 171-183.
28. Selleri, L., Depew, M.J., Jacobs, Y., Chanda, S.K., Tsang, K.Y., Cheah, K.S., Rubenstein, J.L., O'Gorman, S. and Cleary, M.L. (2001) Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. Development, 128, 3543-3557.
29. Taylor, S.S., Buechler, J.A. and Yonemoto, W. (1990) cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Annu. Rev. Biochem., 59, 971-1005.
30. Vogt, T.F. and Duboule, D. (1999) Antagonists go out on a limb. Cell, 99, 563-566.
31. Wagner, K., Mincheva, A., Korn, B., Lichter, P. and Pöpperl, H. (2001) Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis. Mech. Dev., 103, 127-131.
32. Wolff, B., Sanglier, J.J. and Wang, Y. (1997) Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem. Biol., 4, 139-147.