Chitinosan-drug complexes: Effect of electrolyte on naproxen release in vitro

International Journal of Pharmaceutics

Volumn 250, Issue 1, 2003, Pages 259-272

  Rege, Pankaj R ^a,b   Shukla, Dhruti J ^a   Block, Lawrence H ^a  

^a DUQUESNE UNIVERSITY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Chitinosan; Chitosan; Electrolyte; Excipient; Naproxen sodium; Tablets

Indexed keywords

ALUMINUM CHLORIDE; CALCIUM CHLORIDE; CHITINOSAN; CHITOSAN DERIVATIVE; ELECTROLYTE; EXCIPIENT; FUNCTIONAL GROUP; ION; MAGNESIUM STEARATE; NAPROXEN; SODIUM CHLORIDE; UNCLASSIFIED DRUG; CHITIN; DRUG DERIVATIVE;

ANALYSIS OF VARIANCE; AQUEOUS SOLUTION; ARTICLE; COMPLEX FORMATION; COMPRESSIVE STRENGTH; DISSOLUTION; DRUG RELEASE; DRUG SOLUBILITY; GEL; IN VITRO STUDY; IONIZATION; MOLECULAR INTERACTION; MOLECULAR WEIGHT; PH; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET FORMULATION; CHEMISTRY; SOLUBILITY; TABLET; VISCOSITY;

CHITIN; ELECTROLYTES; HYDROGEN-ION CONCENTRATION; NAPROXEN; SOLUBILITY; TABLETS; VISCOSITY;

EID: 0037413405     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00551-3     Document Type: Article

References (21)

1. Acartürk F. Preparation of a prolonged-release tablet formulation of diclofenac sodium, part I: using chitosan. Pharmazie. 44:1989;547-547.
2. Akbuga J. A biopolymer: chitosan. Int. J. Pharm. Adv. 1:1995;3-18.
3. Al-Angary A.A. Effects of molecular weight and particle size of chitosan on chlorpheniramine maleate release from compressed tablets. Saudi Pharm. J. 2:1994;157-162.
4. Austin, P.R., Brine, C.J., 1981. Chitin powder and process for making it. U.S. Patent 4,286,087, 25 August.
5. Block, L.H., 1997. Chitinosans: enabling excipients for drug delivery systems. Internationales Symposium: Chitin/Chitosan Isolierung, Charakterisierung, Anwendung. Lübeck, Germany, 19-20 July.
6. Block L.H., Patel R.N. Solubility and dissolution of triamcinolone acetonide. J. Pharm. Sci. 62:1973;617-621.
7. Fini A., Zecchi V., Tartarini A. Dissolution profiles of NSAID carboxylic acids and their salts with different counterions. Pharm. Acta Helv. 60:1985;58-62.
8. Gordon R.E., Rosanske T.W., Fonner D.E., Anderson N.R., Banker G.S. Granulation technology and tablet characterization. Liebermann H.A., Lachman L., Schwartz J.B. Pharmaceutical Dosage Forms: Tablets. 2:1990;245-348 Marcel Dekker, Inc, New York.
9. Israelachivili J. Interactions involving polar molecules. Israelachivili J. Intermolecular and Surface Forces. 1992;54-56 Academic Press, Inc, San Diego, CA.
10. Insel, P.A., 1996. Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout. In: Hardman, J.G., Limbird, L.E., Molinoff, P.B., Ruddon, R.W., Gilman, A.G. (Eds.), The Pharmacological Basis of the Rapeutics, 9th ed. pp. 617-657.
11. Knapczyk J. Excipient ability of chitosan for direct tableting. Int. J. Pharm. 89:1993;1-7.
12. Machida, Y., Nagai, T., 1989. Chitin/chitosan as pharmaceutical excipients. In: Breimer, D.D., Crommelin, D.J.A., Midha, K.K. (Eds.), Topics in Pharmaceutical Sciences. Federation Internationale Pharmaceutique (F.I.P), The Hague, pp. 211-220.
13. Muzzarelli R.A.A. Biochemical significance of exogenous chitins and chitosans in animals and patients. Carbohydr. Res. 20:1993;7-16.
14. a values of medicinal compounds in pharmacy practice. Drug Intell. Clin. Pharm. 12:1978;546-554.
15. Rege P.R., Shukla D.J., Block L.H. Chitinosans as tableting excipients for modified release delivery systems. Int. J. Pharm. 181:1999;49-60.
16. Sabnis, S.S., 1996. Development of modified chitosans as excipients for use in drug delivery systems. Ph.D. Thesis, Duquesne University, USA, pp. 127-132.
17. Sabnis S.S., Block L.H. Improved infrared spectroscopic method for the analysis of degree of N-deacetylation of chitosan. Polym. Bull. 39:1997;67-71.
18. Sabnis S.S., Rege P.R., Block L.H. Use of chitosan in compressed tablets of diclofenac sodium: inhibition of drug release in an acidic environment. Pharm. Dev. Technol. 2:1997;243-255.
19. Sawayanagi Y., Nambu N., Nagai T. Directly compressed tablets containing chitin or chitosan in addition to lactose or potato starch. Chem. Pharm. Bull. 30:1982;2935-2940.
20. Scott H. Polymer science. Martin A., Swarbrick J., Cammarata A. Physical Pharmacy. 3rd ed. 1991;599-600 Lea and Febiger, Philadelphia.
21. Wolff M., Kersten D., Göber B. Bestimmung und Berechnung von pH-Werten wäβrig-methanolischer Lösungen. Pharmazie. 42:1987;820-823.