Non-classical antifolates, 5-(N-phenylpyrrolidin-3-yl)-2,4,6-triaminopyrimidines and 2,4-Diamino-6(5H)-oxopyrimidines, synthesis and antitumor studies

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 1, 2003, Pages 145-157

  Huang, Yen Lin ^a,b   Lin, Chyun Feng ^a,b   Lee, Yi Jen ^a   Li, Wei Wei ^c   Chao, Ting Chou ^c   Bacherikov, Valeriy A ^a   Chen, Kuo Tung ^b   Chen, Chin Ming ^b   Su, Tsann Long ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ALCOHOL DERIVATIVE; ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; BUTANOL; DEOXYURIDINE; DIHYDROFOLATE REDUCTASE; DOXORUBICIN; FOLIC ACID; FOLIC ACID ANTAGONIST; FOLINIC ACID; GUANIDINE; KETONE DERIVATIVE; MALONONITRILE; METHOTREXATE; PYRIMIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; TRITIUM;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; OXIDATION; POLYMERIZATION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DEOXYURIDINE; DRUG SCREENING ASSAYS, ANTITUMOR; FOLIC ACID; FOLIC ACID ANTAGONISTS; HUMANS; LEUCOVORIN; METHOTREXATE; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TRITIUM; TUMOR CELLS, CULTURED;

TRITIUM;

EID: 0037413345     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00238-9     Document Type: Article

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