Trihalobenzocycloheptapyridine analogues of Sch 66336 as potent inhibitors of farnesyl protein transferase

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 1, 2003, Pages 139-143

  Njoroge, F George ^a   Vibulbhan, Bancha ^a   Pinto, Patrick ^a   Strickland, Corey L ^a   Bishop, W Robert ^a   Kirschmeir, Paul ^a   Girijavallabhan, V ^a   Ganguly, Ashit K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3,10 DIBROMO 8 CHLORO 6,11 DIHYDRO 5H BENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YL) 1 (2 OXO 1 PIPERIDINYL)ACETYLPIPERIDINE; 4 (3,10 DIBROMO 8 CHLORO 6,11 DIHYDRO 5H BENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YL) 1 [(HEXAHYDRO 2 OXO 1 PYRIMIDINYL)ACETYL]PIPERIDINE; 4 (3,10 DIBROMO 8 CHLORO 6,11 DIHYDRO 5H BENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YL) GAMMA OXO 1 PIPERIDINEBUTANAMIDE; ACID; AMIDE; ESTER DERIVATIVE; LACTAM DERIVATIVE; LONAFARNIB; METHYL 4 (3,10 DIBROMO 8 CHLORO 6,11 DIHYDRO 5H BENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YL) GAMMA OXO 1 PIPERIDINEBUTANOATE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SOLUBILITY; DRUG STABILITY; ENZYME INHIBITION; NONHUMAN;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; COS CELLS; ENZYME INHIBITORS; KIDNEY; MODELS, MOLECULAR; PIPERIDINES; PYRIDINES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM;

EID: 0037413341     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00308-5     Document Type: Article

References (12)

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12. Some predicted log P's using Pallas program from CompuDrug are as follows: SCH 66336 (5.0), compound 4c (4.5), compound 10d (4.7).