Pyrrolidinedithiocarbamate induces apoptosis in cerebellar granule cells: Involvement of AP-1 and MAP kinases

Neurochemistry International

Volumn 43, Issue 1, 2003, Pages 31-38

  Porcile, Carola ^a,b   Stanzione, Sabrina ^a   Piccioli, Patrizia ^a   Bajetto, Adriana ^a,b   Barbero, Simone ^a,b   Bisaglia, Michela ^a,b   Bonavia, Rudy ^a,b   Florio, Tullio ^a,c   Schettini, Gennaro ^a,b  

^a CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

Author keywords

AP 1; Apoptosis; Cerebellar granule cells; PDTC

Indexed keywords

ACETYLTYROSYLVALYLALANYLASPARTIC ACID ALDEHYDE; ALDEHYDE DERIVATIVE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CYCLOHEXIMIDE; DACTINOMYCIN; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUPEPTIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PYRROLIDINE DITHIOCARBAMATE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; GRANULE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; APOPTOSIS; BISBENZIMIDE; BLOTTING, WESTERN; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; CYTOPLASMIC GRANULES; DNA FRAGMENTATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLUORESCENT DYES; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE TISSUE PROTEINS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRAZOLIUM SALTS; THIAZOLES; THIOCARBAMATES; TRANSCRIPTION FACTOR AP-1;

EID: 0037411553     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(02)00197-3     Document Type: Article

References (34)

1. Bessho R., Matsubara K., Kubota M., Kuwakado K., Hirota H., Wakazono Y., Lin Y.W., Okuda A., Kawai M., Nishikomori R., Heike T. Pyrrolidinedithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes. Biochem. Pharmacol. 48:1994;1883-1889.
2. Bisaglia M., Venezia V., Piccioli P., Stanzione S., Porcile C., Russo C., Mancini F., Milanese C., Schettini G. Acetaminophen protects hippocampal neurons and PC12 cultures from amyloid β-peptides induced oxidative stress and reduces NF-κB activation. Neurochem. Int. 41:2002;43-54.
3. Brennan P., O'Neill L.A. Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals. Biochim. Biophys. Acta. 1260:1995;167-175.
4. Brennan P., O'Neill L.A. 2-Mercaptoethanol restores the ability of nuclear factor κB (NFκB) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrrolidinedithiocarbamate (PDTC). Biochem. J. 320:1996;975-981.
5. Chung K.C., Park J.H., Kim C.H., Lee H.W., Sato N., Uchiyama Y., Ahn Y.S. Novel biphasic effect of pyrrolidine dithiocarbamate on neuronal cell viability is mediated by the differential regulation of intracellular zinc and copper ion levels, NF-κB and MAPK kinases. J. Neurosci. Res. 59:2000;117-125.
6. Enzinger C., Wirleitner B., Spottl N., Bock G., Fuchs D., Baier-Bitterlich G. Reduced pteridine derivatives induce apoptosis in PC12 cells. Neurochem. Int. 41:2002;71-78.
7. Estus S., Zacks W.J., Freeman R.S., Gruda M., Bravo R., Johnson E.M. Jr. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J. Cell Biol. 127:1994;1717-1727.
8. Galli C., Meucci O., Scorziello A., Werge T.M., Schettini G. Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis. J. Neurosci. 15:1995;1172-1179.
9. Gille H., Sharrocks A.D., Shaw P.E. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature. 358:1992;414-417.
10. Ham J., Babij C., Whitfield J., Lallemand D., Yaniv M., Rubin L.L. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron. 14:1995;927-939.
11. Hayes, W.J., 1982. Pesticides Studied in Man. Williams and Wilkins, Baltimore, pp. 436-462.
12. Hazzalin C.A., Cano E., Cuenda A., Barrat M.J., Cohen P., Mahadevan L.C. p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient. Curr. Biol. 6:1996;1028-1031.
13. Kim C.H., Kim J.H., Moon S.J., Hsu C.Y., Seo J.T., Ahn Y.S. Biphasic effects of dithiocarbamates on the activity of nuclear factor κ-B. Eur. J. Pharmacol. 392:2000;133-136.
14. Kyriakis J.M., Banerjee P., Nikolakaki E., Dai T., Rubie E.A., Ahmad M.F., Avruch J., Woodgett J.R. The stress-activated protein kinase subfamily of c-Jun kinases. Nature. 369:1994;156-160.
15. Lee C.S., Han J.H., Jang Y.Y., Song J.H., Han E.S. Differential effect of catecholamines and MPP(+) on membrane permeability in brain mitochondria and cell viability in PC12 cells. Neurochem. Int. 40:2002;361-369.
16. Mattson M.P., Culmsee C., Yu Z., Camandola S. Roles of nuclear factor κB in neuronal survival and plasticity. J. Neurochem. 74:2000;443-456.
17. Mercurio F., Manning A.M. NF-κB as a primary regulator of the stress response. Oncogene. 18:1999;6163-6171.
18. Mesner P.W., Epting C.L., Hegarty J.L., Green S.H. A timetable of events during programmed cell death induced by trophic factor withdrawal from neuronal PC12 cells. J. Neurosci. 15:1995;7357-7366.
19. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J. 12:1993;2005-2012.
20. Miller T.M., Johnson E.M. Jr. Metabolic and genetic analyses of apoptosis in potassium/serum-deprived rat cerebellar granule cells. J. Neurosci. 16:1996;7487-7495.
21. Muller J.M., Rupec R.A., Baeuerle P.A. Study of gene regulation by NF-κB and AP-1 in response to reactive oxygen intermediates. Methods Enzymol. 11:1997;301-312.
22. Nobel C.S.I., Kimland M., Lind B., Orrenius S., Slater A.F.G. Dithiocarbamates induce apoptosis in thymocytes by raising the intracellular level of redox-active copper. J. Biol. Chem. 270:1995;26202-26208.
23. Park J.W., Youn Y.C., Kwon O.S., Jang Y.Y., Han E.S., Lee C.S. Protective effect of serotonin on 6-hydroxydopamine- and dopamine-induced oxidative damage of brain mitochondria and synaptosomes and PC12 cells. Neurochem. Int. 40:2002;223-233.
24. Piccioli P., Porcile C., Stanzione S., Bisaglia M., Bajetto A., Bonavia R., Schettini G. Inhibition of NF-κB activation induces apoptosis in cerebellar granule cells. J. Neurosci. Res. 6:2001;1064-1073.
25. Shimoke K., Yamagishi S., Yamada M., Ikeuchi T., Hatanaka H. Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons. Brain Res. Dev. Brain Res. 112:1999;45-253.
26. Sunderman F.W. Efficacy of sodium diethyldithiocarbamate (dithiocarb) in acute nickel carbonyl poisoning. Ann. Clin. Lab. Sci. 9:1979;1-10.
27. Taglialatela G., Robinson R., Perez-Polo J.R. Inhibition of nuclear factor kappa B (NFκB) activity induces nerve growth factor-resistant apoptosis in PC12 cells. J. Neurosci. Res. 47:1997;155-162.
28. Thellung S., Villa V., Corsaro A., Arena S., Millo E., Damonte G., Benatti U., Tagliavini F., Florio T., Schettini G. p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells. Neurobiol. Dis. 9:2002;69-81.
29. Watson A., Eilers A., Lallemand D., Kyriakis J., Rubin L.L., Ham J. Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons. J. Neurosci. 18:1998;751-762.
30. Whitmarsh A.J., Davis R.J. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J. Mol. Med. 74:1996;589-607.
31. Wu M., Lee H., Bellas R.E., Schauer S.L., Arsura M., Katz D., FitzGerald M.J., Rothstein T.L., Sherr D.H., Sonenshein G.E. Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO J. 15:1996;4682-4690.
32. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of Erk and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.
33. Yamagishi S., Yamada M., Ishikawa Y., Matsumoto T., Ikeuchi T., Hatanaka H. p38 mitogen-activated protein kinase regulates low potassium-induced c-Jun phosphorylation and apoptosis in cultured cerebellar granule neurons. J. Biol. Chem. 276:2001;5129-5133.
34. Zhang H.X.S., Hampong M., Blanis L. Pelech. J. Biol. Chem. 276:2001;6905-6908.