Poly(ethylene glycol)-conjugated anti-EGF receptor antibody C225 with radiometal chelator attached to the termini of polymer chains

Bioconjugate Chemistry

Volumn 12, Issue 4, 2001, Pages 545-553

  Wen, X ^a   Wu, Q P ^a   Lu, Y ^a   Fan, Z ^a   Charnsangavej, C ^a   Wallace, S ^a   Chow, D ^b   Li, C ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CELL DEATH; CHELATION; ELECTROPHORESIS; ETHYLENE GLYCOL; MONOCLONAL ANTIBODIES; POLYOLS;

BIOLOGICAL BARRIER; CLINICAL APPLICATION; DIETHYLENETRIAMINE PENTA-ACETIC ACIDS; EPIDERMAL GROWTH FACTOR RECEPTORS; IMAGING CHARACTERISTICS; POLYMER CHAINS; RADIOIMMUNOSCINTIGRAPHY; RADIOLABELLING; SYNTHESISED; THIOL GROUPS;

POLYETHYLENE GLYCOLS;

EID: 0034920906     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0001443     Document Type: Article

References (26)

1. Radioimmunoscintigraphy and radioimmunotherapy in cancer: Principles and application
2. Monoclonal antibodies in cancer detection and therapy
3. Indium-111 satumomab pendetide: The first FDA-approved monoclonal antibody for tumor imaging
4. 111In-labeled monoclonal antitumor antibodies in normal animals and nude mouse human tumor models
5. Differences in tumor and normal tissue concentrations of iodine and indium labeled monoclonal antibody II. Biodistribution studies in mice with human tumor xenografts
6. Synthesis of 1-(p-Isothiocyanatobenzyl) derivatives of DTPA and EDTA. Antibody labeling and tumor-imaging studies
7. Macrocyclic chelates of radiometals for diagnosis and therapy
8. Effects of linker chemistry on the pharmacokinetics of radioimmunoconjugates
9. Synthesis, metal chelate stability studies, and enzyme digestion of a peptide-linked DOTA derivative and its corresponding radiolabeled immunoconjugates
10. Pharmacokinetics of chimeric L6 conjugated to indium-111- and yttrium-90-DOTA-peptide in tumor-bearing mice
11. The clinical efficacy of poly(ethylene glycol)-modified proteins
12. Therapeutic antibody fragments with prolonged in vivo half-lives
13. Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes
14. The receptor for EGF and its ligands: Expression, prognostic value and target for therapy in cancer
15. Epidermal growth factor receptor inhibition by a monoclonal antibody as anticancer therapy
16. Ellman's assay for the determination of sulfhydryls
17. Radioactive labeling of antibody: A simple and efficient method
18. Amine detection reagents
19. Imaging of human tumor xenografts with an indium-111-labeled anti-epidermal growth factor receptor monoclonal antibody
20. Phase I and imaging trial of indium 111-labeled anti-epidermal growth factor receptor monoclonal antibody 225 in patients with squamous cell lung carcinoma
21. Chemical engineering of the monoclonal antibody A7 by poly(ethylene glycol) for targeting cancer chemotherapy
22. The potential for enhanced tumor localization by poly(ethylene glycol) modification of anti-CEA antibody
23. Chelating polymer modified monoclonal antibodies for radioimmunodiagnostics and radioimmunotherapy
24. Involvement of p21Waf1 in mediating inhibition of paclitaxel-induced apoptosis by epidermal growth factor in MDA-MB-468 human breast cancer cells
25. Overexpression of the EGF receptor is a hallmark of squamous cell carcinomas
26. Apoptosis and activation of caspase cascade induced by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity