Subchronic oral toxicity study on the three flavouring substances: Octan-3-ol, 2-methylcrotonic acid and oct-3-yl 2-methylcrotonate in Wistar rats

Food and Chemical Toxicology

Volumn 41, Issue 5, 2003, Pages 647-654

  Lindecrona, R H ^a   Molck A M ^a   Gry, J ^a   Poulsen, M ^a   Andersen, R ^a   Thorup, I ^a  

^a DANISH VETERINARY AND FOOD ADMINISTRATION   (Denmark)

Author keywords

2 methylcrotonic acid; Flavouring; Kidney; Liver; Oct 3 yl 2 methylcrotonate; Octan 3 ol; Rat; Subchronic toxicity

Indexed keywords

3 OCTANOL; CROTONIC ACID DERIVATIVE; FOOD DYE; OCT 3 YL 2 METHYLCROTONATE; OCTANOL; TIGLIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE DUCT; BODY WEIGHT; CARDIOMEGALY; CELL PROLIFERATION; CHRONIC TOXICITY; CONTROLLED STUDY; DESQUAMATION; DRUG MEGADOSE; EPITHELIUM CELL; EVALUATION; FEEDING; FEMALE; HISTOPATHOLOGY; KIDNEY; KIDNEY TUBULE; LIVER WEIGHT; MALE; MICROSCOPY; NONHUMAN; OBSERVATION; RAT; TISSUE INJURY; TOXICITY TESTING;

RATTUS NORVEGICUS;

EID: 0037401228     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(02)00327-7     Document Type: Article

References (31)

1. Barrett J.C., Huff J. Cellular and molecular mechanisms of chemically induced renal carcinogenesis. Renal Failure. 13:1991;211-225.
2. Bock K.W., Lilienblum W., Fischer G., Schirmer G., Bock-Hennig B.S. The role of conjugation reactions in detoxication. Archives of Toxicology. 60:1987;22-29.
3. Boorman G.A., McDonald M.R., Imote S., Persing R. Renal lesions induced by Ochratoxin A exposure in the F344 rat. Toxicologic Pathology. 20:1992;236-245.
4. Flavouring Substances and Natural Sources of Flavourings, Vol. I, Chemically-Defined Flavouring Substances. fourth ed:1992;Council of Europe, Maisonneuve, Strasbourg.
5. Dominick M.A., Robertson D.G., Bleavins M.R., Sigler R.E., Bobrowski W.F., Gough A.W. α2μ-Globulin nephropathy without nephrocarcinogenesis in male Wistar rats administered 1-(aminomethyl)cyclohexaneacetic acid. Toxicology and Applied Pharmacology. 111:1991;375-387.
6. European Commission, 1999. Commission Decision 1999/217/EC (OJ L 84, 27.3.1999, p. 1).
7. European Commission, 2000. Commission Regulation (EC) no. 1565/2000 (OJ L 180, 19.7.2000, p. 8).
8. European Commission, 2002. Commission Decision 2002/1137/EC (OJ L 49, 20.2.2002, p. 1).
9. Eustis S.L., Boorman G.A., Harada T., Popp J.A. Liver. Boorman G.A., Eustis S.L., Elwell M.R., Montgomery C.A., MacKenzie W.F. Pathology of the Fischer Rat. 1990;71-94 Academic Press, London.
10. Fenaroli, 1995. In: Burdock, G.A. (Ed.), Fenaroli's Handbook of Flavor Ingredients, Vol. II, third ed. CRC Press, London.
11. JECFA, 1997. Evaluation of certain food additives and contaminants. Forty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, No. 868.
12. JECFA, 1999a. Evaluation of certain food additives and contaminants. Forty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, No. 884.
13. JECFA, 1999b. Safety evaluation of certain food additives. WHO Food Additives series, No. 42.
14. JECFA, 2000a. Evaluation of certain food additives. Fifty-first report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, No. 891.
15. JECFA, 2000b. Evaluation of certain food additives and contaminants. Fifty-third report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, No. 896.
16. Heymann E. Carboxylesterases and amidases. Jacoby W.B. Enzymatic Basis of Detoxication, second ed. 1980;291-323 Academic Press, New York.
17. IOFI, 1994. International Organization of the Flavor Industry. Unpublished results submitted to the Scientific Committee on Food.
18. Kasper C.B., Henton D. Glucuronidation. Jacoby W.B. Enzymatic Basis of Detoxification, Vol. II. 1982;4-36 Academic Press, New York.
19. Kamil I.A., Smith J.N., Williams R.T. Studies in detoxication. The metabolism of aliphatic alcohols. The glucuronic acid conjugation of acyclic aliphatic alcohols. Journal of Biochemistry. 53:1953;129-136.
20. Münzel P.A., Brück M., Bock K.W. Tissue-specific constitutive and inducible expression of rat phenol UDP-glucuronosyltransferase. Biochemical Pharmacology. 47:1994;1445-1448.
21. OECD, 1998. OECD Guideline for the Testing of Chemicals, Repeated Dose 90-day Oral Toxicity Study in Rodents, No. 408, 1-10.
22. Olson M.J., Garg B.D., Murty C.V.R., Roy A.K. Accumulation of α2μ-globulin in the renal proximal tubules of male rats exposed to unleaded gasoline. Toxicology and Applied Pharmacology. 90:1987;43-51.
23. Ritskes-Hoitinga J., Lemmens A.G., Beynen A.C. Nutrition and kidney calcification in rats. Laboratory Animals. 23:1989;313-318.
24. Santos K.D., Rocha M., Wannmacher C.M.D., Wajner M. The influence of organic acids on the proliferation of human peripheral lymphocytes activated by concanavalin A and pokeweed mitogen. International Journal of Immunopharmacology. 18:1996;761-769.
25. SCF, 1995. Annex 6 to the minutes of the 98th meeting of the Scientific Committee on Food, 21 and 22 September.
26. SCF, 1999. Scientific Committee on Food. Opinion on a Programme for the Evaluation of Flavouring Substances (expressed on 2 December 1999).
27. Schlottfeldt J., Blazina L.R., Wannmacher C.M.D., Wajner M. The effect of organic acids on phytohaemaglutinin-activated proliferation of human lymphocytes in vitro. International Journal of Immunopharmacology. 17:1995;175-182.
28. Stofberg J., Grundschober F. The consumption ratio and food predominance of flavoring materials. Perfumer and Flavorist. 12:1987;27-56.
29. Stofberg J., Kirschman J.C. The consumption ratio of flavoring materials. a mechanism for setting priorities for safety evaluation Food and Chemical Toxicology. 23:1985;857-860.
30. Strassburg C.P., Nguyen N., Manns M.P., Tukey R.H. Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium. Molecular Pharmacology. 54:1998;647-654.
31. Volatile Compounds in Food-VCF Database, Boelens Aroma Chemical Information Service BACIS. 2000;TNO Nutrition and Food Research Institute, Zeist, The Netherlands.