The end of treatment with antioxidative vitamins;Das ende der supplementierung mit antioxidativen vitaminen

Aktuelle Ernahrungsmedizin

Volumn 28, Issue 2, 2003, Pages 113-120

  Heyden, Siegfried ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

carotene; Clinical outcome; Supplements; Vitamin C; Vitamin E

Indexed keywords

ANTIOXIDANT; BETA CAROTENE; VITAMIN;

ATHEROGENESIS; CANCER; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DOSE RESPONSE; HUMAN; INCIDENCE; ISCHEMIC HEART DISEASE; LUNG CARCINOMA; REVIEW; RISK FACTOR; SMOKING; TREATMENT PLANNING; VITAMIN SUPPLEMENTATION;

EID: 0037396042     PISSN: 03410501     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-37985     Document Type: Review

References (30)

1. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994; 330: 1029-1035
2. Hennekens CH, Buring JE, Peto R. Antioxidant vitamins-benefits not yet proved. Editorial. N Engl J Med 1994; 336: 1080-1081
3. Hennekens CH, Buring JE, Manson JE, Stampfer N et al. Lack of effect of long-time supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 1996; 334: 1145-1149
4. Greenberg ER, Sporn MB. Antioxidant vitamins, cancer and cardiovascular disease. Editorial. N Engl J Med 1996; 334: 12189-12190
5. Liu SM, Ajani U, Chae C, Hennekens CH, Buring JE, Manson JE. Longterm beta-carotene supplementation and risk of type 2 diabetes mellitus. A randomized controlled trial. JAMA 1999; 282: 1073-1075
6. Ascherio A, Rimm EB, Herman MA, Giovannucci E, Kawachi I, Stampfer MJ, Willett WC. Relation of consumption of vitamin E, vitamin C and carotenoids to risk for stroke among men in the United States. Ann Intern Med 1999; 15: 963-970
7. Omenn GS, Goodman GE, Thornquist MD et al. Effects of a combination of the beta-carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996; 334: 1150-1155
8. Leo MA, Lieber CS. Alcohol, vitamin A and β-carotene: adverse interactions, including hepatotoxicity and carcinogenicity. Am J Clin Nutr 1999; 69: 1071-1085
9. Rapola JM, Albanes D, Taylor PR, Huffenen JK. Effect of vitamin E and beta carotene on the incidence of angina pectoris. JAMA 1996; 275: 693-698
10. The Heart Outcome Prevention Evaluation Study Investigators. Vitamin E supplementation and cardiovascular events in high-risk-patients. N Engl J Med 2000; 342: 154-160
11. The Heart Outcome Prevention Evaluation Study Investigators. Effects of an angiotensin converting-enzyme inhibitor, ramipril on cardiovascular events in high-risk-patients. N Engl J Med 2000; 342: 145-153
12. Raal RF, Pilcher GJ, Veller MG, Kotze MJ, Joffe B. Efficacy of vitamin E compared with either simvastatin or atorvastatin in preventing the progression of atherosclerosis in homozygous familial hypercholesterolemia. Am J Cardiol 1999; 84: 1344-1348
13. GISSI Prevenzione Investigators. Dietary supplementation with ω-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999; 354: 447-455
14. Marchioli RM, Barzi F, Bomba E, Chieffo C, DiGregorio D et al. Early protection against sudden death by ω-3 polyunsaturated fatty acids after myocardial infarction. Time-course analysis of the results of the GISSI-Prevenzione. Circulation 2002; 105: 1897-1903
15. Heart Protection Study Collaborative Group. Heart Protection Study of antioxidant vitamin supplementation in 20536 high-risk individuals: a randomized, placebo-controlled trial. Lancet 2002; 360: 7-22
16. Enstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology 1992; 3: 194-202
17. Herbert V. Vitamin C-supplement and disease - counterpoint. Editorial. J Am Coll Nutr 1995; 14: 112-113
18. Stampfer MJ, Hennekens CH, Manson JA, Colditz GA, Rosner B, Willett WC. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 1993; 328: 1444-1449
19. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett W. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993; 328: 1450-1456
20. Kushi LH, Folsom AR, Prineas RJ, Mink PJ, Wu Y, Bostick RM. Dietary antioxidant vitamins and the death from coronary heart disease in postmenopausal women. N Engl J Med 1996; 334: 1156-1162
21. Herbert V, Shaw S, Jayatilleke E. Vitamin C supplements are harmful to lethal for the 10% of Americans with high iron stores. FASEB J 1994; 8: A678
22. Dwyer JH, Nicholson LM, Shricore A, Sun P. Vitamin C supplement intake and progression of carotid atherosclerosis, the Los Angeles Atherosclerosis Study. Abstract. San Diego, California: Am Heart Assoc Congress, March 2000
23. Lee SH, Oe T, Blair IA. Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins. Science 2001; 292: 2083-2086
24. Kuller LH. Time to stop prescribing antioxidant vitamins to prevent and treat heart disease? Editorial. Arterioscler Thromb Vasc Biol 2001; 21: 1253
25. Brown BG, Zhai XQ, Chait A, Fisher LD et al. Simvastatin and niacin, antioxidant vitamins or the combination for the prevention of coronary disease. N Engl J Med 2001; 345: 1583-1592
26. Schäfer-Elinder L, Hädeel K, Johansson J, Molgaard J, Holme I, Olsson AG, Walldius G. Probucol treatment decreases serum concentrations of diet derived antioxidants. Arterioscler Thromb Vasc Biol 1995; 15: 1057-1063
27. Freedman JE. Antioxidant versus lipid-altering therapy - some answers, more questions. Editorial. N Engl J Med 2001; 345: 1636-1637
28. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol: modifications of low density lipoprotein that increase its atherogenicity. N Engl J Med 1989; 320: 915-924
29. Patsch J. Interview. Årzte-Zeitung 1992; Nr. 89, 11: 12-13
30. Steinberg D. Antioxidant vitamins and coronary heart disease. N Engl J Med 1993; 328: 1487-1489