GABA and mood disorders

Psychological Medicine

Volumn 33, Issue 3, 2003, Pages 387-393

  Taylor, M ^a   Bhagwagar, Z ^a   Cowen, Philip J ^a   Sharp, T ^a  

^a WARNEFORD HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID C RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; BACLOFEN; BENZODIAZEPINE DERIVATIVE; FENGABINE; GABAPENTIN; GLUTAMATE DECARBOXYLASE; GLUTAMIC ACID; LITHIUM; NEUROTRANSMITTER; PROGABIDE; SEROTONIN; SEROTONIN 2A AGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 3 AGONIST; SEROTONIN 3 RECEPTOR; TOPIRAMATE; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG; VALPROIC ACID; VIGABATRIN;

AMINO ACID BLOOD LEVEL; ANXIETY DISORDER; BIPOLAR DISORDER; BRAIN CORTEX; BRAIN NERVE CELL; CEREBROSPINAL FLUID; DRUG EFFICACY; DRUG MECHANISM; DRUG TOLERABILITY; EDITORIAL; ELECTROCONVULSIVE THERAPY; GABAERGIC TRANSMISSION; HIPPOCAMPUS; HUMAN; INNERVATION; INTERNEURON; LIMBIC CORTEX; MAJOR DEPRESSION; MESENCEPHALON; MOOD DISORDER; NERVE CELL NETWORK; NEUROPATHOLOGY; NEUROTRANSMISSION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN FUNCTION; PYRAMIDAL NERVE CELL; RAPHE NUCLEUS;

BRAIN; GAMMA-AMINOBUTYRIC ACID; HUMANS; LIMBIC SYSTEM; MAGNETIC RESONANCE SPECTROSCOPY; MOOD DISORDERS; RAPHE NUCLEI; RECEPTORS, GABA-A; SEROTONIN; SEROTONIN AGENTS;

EID: 0037389184     PISSN: 00332917     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0033291702006876     Document Type: Editorial

References (61)

1. 2 receptor regulation of extracellular GABA levels in the prefrontal cortex. Neuropsychopharmacology 20, 92-96.
2. Behar, K. L., Rothman, D. L., Petersen, K. F., Hooten, M., Delaney, R., Petroff, O. A., Shulman, G. I., Navarro, V., Petrakis, I. L., Charney, D. S. & Krystal, J. H. (1999). Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients. American Journal of Psychiatry 156, 952-954.
3. Benes, F. M., Vincent, S. L. & Todtenkopf, M. (2001). The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects. Biological Psychiatry 50, 395-406.
4. Berrettini, W. H.. Nurnberger, J. I. Jr., Hare, T. A., Simmons-Alling, S., Gershon, E. S. & Post, R. M. (1983). Reduced plasma and CSF gamma-aminobutyric acid in affective illness: effect of lithium carbonate. Biological Psychiatry 18, 185-194.
5. Bhagwagar, Z., Whale, R. & Cowen, P. J. (2002). State and trait abnormalities in serotonin function in major depression. British Journal of Psychiatry 180, 24-28.
6. Billinton, A., Ige, A. O., Bolam, J. P., White, J. H., Marshall, F. H. & Emson, P. C. (2001). Advances in the molecular understanding of GABA(B) receptors. Trends in Neurosciences 24, 277-282.
7. Bormann, J. (2000). The 'ABC' of GABA receptors. Trends in Pharmacological Sciences 21, 16-19.
8. Coffman, J. A. & Petty, F. (1985). Plasma GABA levels in chronic alcoholics. American Journal of Psychiatry 142, 1204-1205.
9. Cotter, D. R., Pariante, C. M. & Everall, I. P. (2001). Glial cell abnormalities in major psychiatric disorders: the evidence and implications. Brain Research Bulletin 55, 585-595.
10. DeFelipe, J., Arellano, J. I., Gomez, A., Azmitia, E. C. & Munoz, A. (2001). Pyramidal cell axons show a local specialization for GABA and 5-HT inputs in monkey and human cerebral cortex. Journal of Comparative Neurology 433, 148-155.
11. Emrich, H. M., von Zerssen, D., Kissling, W., Moller, H. J. & Windorfer, A. (1980). Effect of sodium valproate on mania. The GABA-hypothesis of affective disorders. Archiv für Psychiatrie und Nervenkrankheiten 229, 1-16.
12. Enna, S. J., Ziegler, M. G., Lake, C. R., Wood, J. H., Brooks, B. R. & Butler, I. J. (1980). Cerebrospinal fluid gamma-aminobutyric acid. In Neurobiology of Cerebrospinal Fluid (ed. J. H. Wood), pp. 189-196. Plenum Press: New York.
13. Freund, T. F., Gulyas, A. I., Acsady, L., Gores, T., & Toth, K. (1990). Serotonergic control of the hippocampus via local inhibitory interneurons. Proceedings of the National Academy of Sciences of the United States of America 87, 8501-8505.
14. Furukawa, T. A., Streineir, D. L. & Young, L. T. (2001). Is antidepressant-benzodiazepine combination therapy clinically more useful? A meta-analytic Study. Journal of Affective Disorders 65, 173-177.
15. Gellman, R. L. & Aghajanian, G. K. (1993). Pyramidal cells in piriform cortex receive a convergence of inputs from monoamine activated GABAergic interneurons. Brain Research 600, 63-73.
16. Goddard, A. W., Mason, G. F., Almai, A., Rothman, D. L., Behar, K. L., Petroff, O. A., Charney, D. S. & Krystal, J. H. (2001). Reductions in occipital cortex GABA levels in panic disorder detected with 1H-magnetic resonance spectroscopy. Archives of General Psychiatry 58, 556-561.
17. B receptor function in mice, is enhanced by antidepressant drugs and ECS. British Journal of Pharmacology 92, 863-870.
18. Gulyas, A. I., Megias, M., Emri, Z. & Freund, T. F. (1999). Total number and ratio of excitatory and inhibitory synapses converging onto single interneurons of different types in the CA1 area of the rat hippocampus. Journal of Neuroscience 19, 10082-10097.
19. Gupta, A., Wang, Y. & Markram, H. (2000). Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex. Science 287, 273-278.
20. Hajos, M., Richards, C. D., Szekely, A. D. & Sharp, T. (1998). An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat. Neuroscience 87, 95-108.
21. Harrison, P. J. (2002). The neuropathology of primary mood disorder. Brain 125, 1428-1449.
22. Honig, A., Bartlett. J. R., Bouras, N. & Bridges, P. K. (1988). Amino acid levels in depression: a preliminary investigation. Journal of Psychiatric Research 22, 159-164.
23. 3 receptors in inhibitory circuits of the primate cerebral cortex. Journal of Comparative Neurology 417, 337-348.
24. Jones, E. G. (1987). GABA-peptide neurons in primate cerebral cortex. Journal of Mind and Behavior 8, 519-536.
25. Kuzniecky, R., Hetherington, H., Ho, S., Pan, J., Martin, R., Gilliam, F., Hugg, J. & Faught, E. (1998). Topiramate increases cerebral GABA in healthy humans. Neurology 51, 627-629.
26. Kwon, J. S., O'Donnell, B. F., Wallenstein, G. V., Greene, R. W., Hirayasu, Y., Nestor, P. G., Hasselmo, M. E., Potts, G. F., Shenton, M. E. & McCarley, R. W. (1999). Gamma frequency-range abnormalities to auditory stimulation in schizophrenia. Archives of General Psychiatry 56, 1001-1005.
27. Lloyd, K. G., Morselli, P. L., Depoortere, H., Fournier, V., Zivkovic, B., Scatton, B., Broekkamp, C., Worms, P. & Bartholini, G. (1983). The potential use of GABA agonists in psychiatric disorders: evidence from studies with progabide in animal models and clinical trials. Pharmacology, Biochemistry and Behavior 18, 957-966.
28. McBain, C. J. & Fisahn, A. (2001). Interneurons unbound. Nature Reviews Neuroscience 2, 11-23.
29. Magni, G., Garreau, M., Orofiamma, B. & Palminteri, R. (1989). Fengabine, a new GABAmimetic agent in the treatment of depressive disorders: an overview of six double-blind studies versus tricyclics. Neuropsychobiology 20, 126-131.
30. Mason, G. F., Sanacora, G., Anand, A., Epperson, N., Goddard, A., Rothman, D., Charney, D. & Krystal, J. (2000). Cortical GABA differs between unipolar and bipolar depression. Proceedings of the International Society for Magnetic Resonance in Medicine 8, 521.
31. Mason, G. F., Sanacora, G., Hundal, R., Petersen, K., Shulman, G., de Graaf, R., Rothman, D. & Krystal, J. (2001). Preliminary evidence of reduced cortical GABA synthesis rate in major depression. Society for Neuroscience Abstracts 27, 142.6.
32. Mattson, R. H., Petroff, O., Rothman, D. & Behar, K. (1994). Vigabatrin: effects on human brain GABA levels by nuclear magnetic resonance spectroscopy. Epilepsia 35 (Suppl. 5), S29-S32.
33. Morales, M., Battenberg, E., De Lecea, L. & Bloom, F. E. (1996). The type 3 serotonin receptor is expressed in a subpopulation of GABAergic neurons in the rat neocortex and hippocampus. Brain Research 731, 199-202.
34. Nielsen, N. P., Cesana, B., Zizolfi, S., Ascalone, V., Priore, P. & Morselli, P. L. (1990). Therapeutic effects of fengabine, a new GABAergic agent, in depressed outpatients: a double-blind study versus clomipramine. Acta Psychiatrica Scandinavica 82, 366-371.
35. Paykel, E. S., Van Woerkom, A. E., Walters, D. E., White, W. & Mercer, J. (1991). Fengabine in depression: a placebo-controlled study of a GABA agonist. Human Psychopharmacology 6, 147-154.
36. Perry E. K., Gibson P. H., Blessed G., Perry R. H. & Tomlinson B. E. (1977). Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue. Journal of the Neurological Sciences 34, 247-265.
37. Petroff, O. A., Rothman, D. L., Behar, K. L., Lamoureux, D. & Mattson, R. H. (1996). The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. Annals of Neurology 39, 95-99.
38. Petty, F., Kramer, G. L., Fulton, M., Moeller, F. G. & Rush, A. J. (1993a). Low plasma GABA is a trait-like marker for bipolar illness. Neuropsychopharmacology 9, 125-132.
39. Petty, F., Kramer, G. L. & Hendrickse, W. (1993b). GABA and depression. In Biology of Depressive Disorders, Part A: A Systems Perspective (ed. J. J. Mann and D. J. Kupfer), pp. 79-108. Plenum Press: New York.
40. Petty, F., Fulton, M., Moeller, F. G., Kramer, G., Wilson, L., Fraser, K. & Isbell, P. (1993c). Plasma gamma-aminobutyric acid (GABA) is low in alcoholics. Psychopharmacology Bulletin 29, 277-281.
41. Petty, F., Kramer, G. L., Fulton, M., Davis, L. & Rush, A. J. (1995). Stability of plasma GABA at four-year follow-up in patients with primary unipolar depression. Biological Psychiatry 37, 806-810.
42. Petty, F., Fulton, M., Kramer, G. L., Kram, M., Davis, L. L. & Rush, A. J. (1999). Evidence for the segregation of a major gene for human plasma GABA levels. Molecular Psychiatry 4, 587-589.
43. Rainnie, D. G. (1999). Serotonergic modulation of neurotransmission in the rat basolateral amygdala. Journal of Neurophysiology 82, 69-85.
44. Rothman, D. L., Petroff, O. A., Behar, K. L. & Mattson, R. H. (1993). Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. Proceedings of the National Academy of Sciences of the United States of America 90, 5662-5666.
45. Roy, A., Dejong, J., Lamparski, D., George, T. & Linnoila, M. (1991). Depression among alcoholics. Relationship to clinical and cerebrospinal fluid variables. Archives of General Psychiatry 48, 428-432.
46. Rudolph, U., Crestani, F. & Mohler, H. (2001). GABA(A) receptor subtypes: dissecting their pharmacological functions. Trends in Pharmacological Sciences 22, 188-194.
47. Sailasuta, N., LeRoux, P., Hurd, R., Wang, P., Sachs, N. & Ketter, T. (2001). Detection of cerebral gamma-aminobutyric acid (GABA) in bipolar disorder patients and healthy volunteers at 3T. Proceedings of the International Society for Magnetic Resonance in Medicine 9, 1011.
48. Sanacora, G., Mason, G. F., Rothman, D. L., Behar, K. L., Hyder, F., Petroff, O. A., Berman, R. M., Charney, D. S. & Krystal, J. H. (1999). Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Archives of General Psychiatry 56, 1043-1047.
49. Sanacora, G., Mason, G. F. & Krystal, J. H. (2000). Impairment of GABAergic transmission in depression: new insights from neuroimaging studies. Critical Reviews in Neurobiology 14, 23-45.
50. Sanacora, G., Mason, G. F., Rothman, D., Epperson, N., Goddard, A., Zimolo, Z., Heninger, G. & Krystal, J. H. (2001). Cortical GABA differentiates depressive subtypes. Society for Neuroscience Abstracts 27, 785.6.
51. Sargent, P. A., Kjaer, K. H., Bench, C. J., Rabiner, E. A., Messa, C., Meyer, J., Gunn, R. N., Grasby, P. M. & Cowen, P. J. (2000). Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Archives of General Psychiatry 57, 174-180.
52. Sesack, S. R., Deutch, A. Y., Roth, R. H. & Bunney, B. S. (1989). Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. Journal of Comparative Neurology 290, 213-242.
53. Shiah, I. S., Yatham, L. N. & Baker, G. B. (2000). Divalproex sodium increases plasma GABA levels in healthy volunteers. International Clinical Psychopharmacology 15, 221-225.
54. Smiley, J. F. & Goldman-Rakic, P. S. (1996). Serotonergic axons in monkey prefrontal cerebral cortex synapse predominantly on interneurons as demonstrated by serial section electron microscopy. Journal of Comparative Neurology 367, 431-443.
55. Tao, R. & Auerbach, S. B. (2000). Regulation of serotonin release by GABA and excitatory amino acids. Journal of Psychopharmacology 14, 100-113.
56. Varela, F., Lachaux, J. P., Rodriguez, E. & Martinerie, J. (2001). The brainweb: phase synchronization and large-scale integration. Nature Reviews: Neuroscience 2, 229-239.
57. Varga, V., Kocsis, B. & Sharp, T. (2001a). Electrophysiological evidence for the convergence or inputs from the medial prefrontal cortex and lateral habenula on single neurones in the dorsal raphe nucleus. Society Neuroscience Abstracts 701.20.
58. Varga, V., Szekely, A. D., Csillag, A., Sharp, T. & Hajos, M. (2001b). Evidence for a role of GABA interneurones in the cortical modulation of midbrain 5-hydroxytryptamine neurones. Neuroscience 106, 783-792.
59. Wang, Q. P., Ochiai, H. & Nakai, Y. (1992). GABAergic innervation of Serotonergic neurons in the dorsal raphe nucleus of the rat studied by electron microscopy double immunostaining. Brain Research Bulletin 29, 943-948.
60. Wang, R. Y. & Aghajanian, G. K. (1977). Physiological evidence for habenula as major link between forebrain and midbrain raphe. Science 197, 89-91.
61. Willins, D. L., Deutch, A. Y. & Roth, B. L. (1997). Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse 27, 79-82.