Effects of levonorgestrel-releasing intra-uterine system on the expression of vascular endothelial growth factor and adrenomedullin in the endometrium in adenomyosis

Human Reproduction

Volumn 18, Issue 4, 2003, Pages 694-699

  Laoag Fernandez, J B ^a   Maruo, T ^a   Pakarinen, P ^b   Spitz, I M ^c   Johansson, E ^d  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF HELSINKI   (Finland)

^c SHAARE ZEDEK MEDICAL CENTER   (Israel)

^d POPULATION COUNCIL   (United States)

Author keywords

Adrenomedullin; Endometrium; Levonorgestrel releasing intra uterine system; Vascular endothelial growth factor

Indexed keywords

ADRENOMEDULLIN; AVIDIN; BIOTIN; LEVONORGESTREL; PEROXIDASE; VASCULOTROPIN;

ADENOMYOSIS; ADULT; ARTICLE; BLEEDING DISORDER; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CURETTAGE; DISEASE ASSOCIATION; DRUG EFFECT; ENDOMETRIUM; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MENORRHAGIA; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STROMA;

INSERTION SEQUENCES;

EID: 0037384344     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/deg179     Document Type: Article

References (60)

1. Barbosa, I., Bakos, O., Olsson, S.E., Odlind, V. and Johansson, E.D. (1990) Ovarian function during use of a levonorgestrel-releasing IUD. Contraception, 42, 51-66.
2. Barrington, J.W. and Bowen-Simpkins, P. (1997) The levonorgestrel intrauterine system in the management of menorrhagia. Br. J. Obstet. Gynaecol., 104, 614-616.
3. Charnock-Jones, D.S., Sharkey, A.M., Rajput-Williams, J., Burch, D., Schofield, J.P., Fountain, S.A., Boocock, C.A. and Smith, S.K. (1993) Identification and localization of alternately spliced mRNAs for vascular endothelial growth factor in human uterus and estrogen regulation in endometrial carcinoma cell lines. Biol. Reprod., 48, 1120-1128.
4. Charnock-Jones, D.S., Macpherson, A.M., Archer, D.F., Leslie, S., Makkink, W.K., Sharkey, A.M. and Smith, S.K. (2000) The effect of progestins on vascular endothelial growth factor, oestrogen receptor and progesterone receptor immunoreactivity and endothelial cell density in human endometrium. Hum. Reprod., 15 (Suppl. 3), 85-95.
5. Fedele, L., Portuese, A., Bianchi, S., Raffaelli, R., Portuese, A. and Dorta, M. (1997) Treatment of adenomyosis-associated menorrhagia with a levonorgestrel-releasing intrauterine device. Fertil. Steril., 68, 426-429.
6. Fedele, L., Gammaro, L. and Bianchi, S. (1999) Levonorgestrel-releasing intrauterine device for the treatment of menometrorrhagia in the woman on hemodialysis. N. Engl. J. Med., 341, 541.
7. Filippatos, G., Gangopadhyay, N., Lalude, O., Darameswaran, N., Said, S., Spielman, W. and Uhal, B. (2001) Regulation of apoptosis by vasoactive peptides. Am. J. Physiol. Cell. Mol. Physiol., 281, L749-L761.
8. Fraser, H.M. and Lunn, S.F. (2000) Angiogenesis and its control in the female reproductive system. Br. Med. Bull., 56, 787-797.
9. Gargett, C.E. and Rogers, P.A. (2001) Human endometrial angiogenesis. Reproduction, 121, 181-186.
10. Gargett, C., Lederman, F., Heryanto, B., Gambino, L. and Rogers, P.A.W. (2001) Focal vascular endothelial growth factor correlates with angiogenesis in human endometrium. Role of intravascular neutrophils. Hum. Reprod., 16, 1065-1075.
11. Goodger Macpherson, A.M. and Rogers, P.A.W. (1994) Endometrial endothelial cell proliferation during the menstrual cycle. Hum. Reprod., 9, 1647-1651.
12. Greb, R.R., Heikinheimo, O., Williams, R.F., Hodgen, G.D. and Goodman, A.L. (1997) Vascular endothelial growth factor in primate endometrium is regulated by oestrogen-receptor and progesterone-receptor ligands in vivo. Hum. Reprod., 12, 1280-1292.
13. Hague, S., Zhang, L., Oehler, M.K., Manek, S., MacKenzie, I.Z., Bicknell, R. and Rees, M.C.P. (2000) Expression of hypoxically regulated angiogenic factor adrenomedullin correlates with uterine leiomyoma vascular density. Clin. Cancer Res., 6, 2808-2814.
14. Hague, S., Mackenzie, I.Z., Bicknell, R. and Rees, M.C.P. (2002) In-vivo angiogenesis and progestogens. Hum. Reprod., 17, 786-793.
15. Herbst, A.L., Mishell, D.R., Stenchever, M. and Droegemueller, W. (1992) Comprehensive Gynecology. 2nd edn. Mosby Year-book, St Louis, Missouri, USA.
16. Hickey, M., Simbar, M., Markham, R., Young, L., Manconi, F., Russell, P. and Fraser, I.S. (1999) Changes in vascular basement membrane in the endometrium of Norplant users. Hum. Reprod., 14, 716-721.
17. Ikomi, A. and Gupta, N. (1998) Randomized controlled trial exists in levonorgestrel intrauterine system for menorrhagia. Br. Med. J., 317, 1250.
18. Jerat, S. and Kaufman, S. (1998) Effect of pregnancy and steroid hormones on plasma adrenomedullin levels in the rat. Can. J. Physiol. Pharmacol., 76, 463-466.
19. Kaiserman-Abramof, I.R. and Padykula, H.A. (1989) Angiogenesis in the postovulatory primate endometrium: The coiled arteriolar system. Anat. Rec., 224, 479-489.
20. Kerstin Andersson, J. and Rybo, G. (1990) Levonorgestrel-releasing intrauterine device in the treatment of menorrhagia. Br. J. Obstet. Gynaecol., 97, 690-694.
21. Koolwijk, P., Kapiteijn, K., Molenaar, B., Van Spronsen, E., Van Der Vecht, B., Helmerhorst, F. and Van Hinsbergh, V. (2001) Enhanced angiogenic activity and urokinase-type plasminogen activator expression by endothelial cells isolated from human endometrium. J. Clin. Endocrinol. Metab., 86, 3359-3367.
22. Laoag-Fernandez, J.B., Otani, T. and Maruo, T. (2000) Adrenomedullin expression in the human endometrium. Endocrine, 12, 15-19.
23. Lau, T.M. and Affandi, B. and Rogers, P.A.W. (1998) The effects of levonorgestrel implants on vascular endothelial growth factor expression in the endometrium. Mol. Hum. Reprod., 5, 57-63.
24. Li, X.F., Gregory, J. and Ahmed A. (1994) Immunolocalisation of vascular endothelial growth factor in human endometrium. Growth Factors, 11, 277-282.
25. Li, Z., Takeuchi, S., Otani, T. and Maruo, T. (2001) Implications of adrenomedullin expression in the invasion of squamous cell carcinoma of the uterine cervix. Int. J. Clin. Oncol., 6, 263-270.
26. Macpherson, A.M., Archer, D.F., Leslie, S., Charnock-Jones, D.S., Makkink, W.K. and Smith, S.K. (1999) The effect of etonorgestrel on VEGF, oestrogen, and progesterone receptor immunoreactivity and endothelial cell number in human endometrium. Hum. Reprod., 14, 3080-3087.
27. Markee, J.E. (1978) Menstruation in intraocular endometrial implants in the rhesus monkey. Am. J. Obstet. Gynecol., 131, 558-559.
28. Maruo, T. and Mochizuki, M. (1987) Immunohistochemical localization of epidermal growth factor receptor and myc oncogene product in the human placenta: Implication for trophoblast proliferation and differentiation. Am. J. Obstet. Gynecol., 156, 721-727.
29. Maruo, T., Laoag-Fernandez, J.B., Pakarinen, P., Murakoshi, H., Spitz I.M. and Johansson, E. (2001) Effects of levonorgestrel-releasing intrauterine system on proliferation and apoptosis in the endometrium. Hum. Reprod., 16, 2103-2108.
30. Michishita, M., Minegishi, T., Abe, K., Kangawa, K., Kojima, M. and Ibuki, Y. (1999) Expression of adrenomedullin in the endometrium of the human uterus. Obstet. Gynecol. 93, 66-70.
31. Miller, M.J., Martinez, A., Unsworth, E.J., Thiele, C.J., Moody, T.W., Elsasser, T. and Cuttita, F. (1996) Adrenomedullin expression in human tumor cell lines: Its potential role as an autocrine growth factor. J. Biol. Chem., 271, 23345-23351.
32. Moller, B., Lindblom, B. and Olovsson, M. (2001) Expression of angiogenic growth factors VEGF, FGF-2, EGF and their receptors in normal human endometrium during the menstrual cycle. Mol. Hum. Reprod., 7, 65-72.
33. Moriyama, T., Otani, T. and Maruo, T. (2000) Expression of adrenomedullin by human granulosa lutein cells and its effect on progesterone production. Eur. J. Endocrinol., 142, 671-676.
34. Moriyama, T., Otani, T. and Maruo, T. (2002) Expression of adrenomedullin by human placental cytotrophoblasts and choriocarcinoma JAr cells. J. Clin. Endocrinol. Metab., 86, 3958-3961.
35. Nagata, D., Hirata, Y., Suzuki, E., Kakoki, M., Hayakawa, H., Goto, A., Ishimitsu, T., Minamino, N., Ono, Y., Kangawa, K. et al. (1999) Hypoxia-induced adrenomedullin production in the kidney. Kidney Int., 55, 1259-1267.
36. Nayak, N. and Brenner, R. (2002) Vascular proliferation and vascular endothelial growth factor expression in the rhesus macaque endometrium. J. Clin. Endocrinol. Metab., 87, 1845-1855.
37. Nikitenko, L.L., MacKenzie, I.Z., Rees, M.C.P. and Bicknell, R. (2000) Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium. Mol. Hum. Reprod., 6, 811-819.
38. Oehler, M.K., Rees. M.C. and Bicknell, R. (2000) Steroids and the endometrium. Curr. Med. Chem., 7, 543-560.
39. Rees, M., Hague, S., Ohler, M.K. and Bicknell, R. (1999) Regulation of endometrial angiogenesis. Climacteric, 2, 52-58.
40. Rogers, P.A.W. and Gargett, C.E. (1999) Endometrial angiogenesis. Angiogenesis, 2, 287-294.
41. Rogers, P.A.W., Au, C.L. and Affandi, B. (1993) Endometrial microvascular density during the normal menstrual cycle and following exposure to long-term levonorgestrel. Hum. Reprod., 8, 1396-1404.
42. Rogers, P.A., Lederman, F. and Taylor, N. (1998) Endometrial vascular growth in normal and dysfunctional states. Hum. Reprod. Update, 4, 503-508.
43. Sata, M., Kakoki, M., Nagata, D., Nishimatsu, H., Suzuki, E., Aoyagi, T., Suguira, S., Kojima, H., Nagano, T., Kangawa, K. et al. (2000) Adrenomedullin and nitric oxide inhibit endothelial cell apoptosis via a cyclic GMP-independent mechanism. Hypertension, 36, 83-88.
44. Sharkey, A.M., Day, K., McPherson, A., Malik, S., Licence, D., Smith, S.K. and Charnock-Jones, D.S. (2000) Vascular endothelial growth factor expression in human endometrium is regulated by hypoxia. J. Clin. Endocrinol. Metab., 85, 402-409.
45. Shichiri, M., Kato, H., Doi, M., Marumo, F. and Hirata, Y. (1999) Induction of max by adrenomedullin and calcitonin gene-related peptide antagonizes endothelial apoptosis. Mol. Endocrinol., 13, 1353-1363.
46. Shifren, J.L., Tseng, J.F., Zaloudek, C.J., Ryan, I.P., Meng, Y.G., Ferrara, N., Jaffe, R.B. and Taylor, R.N. (1996) Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: Implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J. Clin. Endocrinol. Metab., 81, 3112-3118.
47. Shweiki, D., Itin, A., Neufeld, G., Gitay-Goren, H. and Keshet, E. (1993) Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis. J. Clin. Invest., 91, 2235-2243.
48. Silverberg, S.G., Haukkamaa, M., Arko, H., Nilsson, C.G. and Luukkainen, T. (1986) Endometrial morphology during long-term use of levonorgestrel-releasing intrauterine devices. Int. J. Gynecol. Pathol., 5, 235-241.
49. Sivin, I. and Stern, J. (1994) Health during prolonged use of levonorgestrel 20 mg/d and the copper Tcu 380 Ag intrauterine contraceptive devices: A multicenter study. Fertil. Steril., 61, 70-77.
50. Smith, S.K. (1995) Angiogenic growth factor expression in the uterus. Hum. Reprod. Update, 1, 162-172.
51. Smith, S.K. (1996) Vascular endothelial growth factor and the endometrium. Hum. Reprod., 11 (Suppl. 2), 56-61.
52. Smith, S.K. (2001) Regulation of angiogenesis in the endometrium. Trends Endocrinol. Metab., 12, 147-151.
53. Song, J.Y., Markham, R., Russell, P., Wong, T., Young, L. and Fraser, I.S. (1995) The effect of high-dose medium- and long-term progesterone exposure on endometrial vessels. Hum. Reprod., 10, 797-800.
54. Sturridge, F. and Guillebaud, J. (1997) Gynaecological aspects of the levonorgestrel-releasing intrauterine system. Br. J. Obstet. Gynaecol., 104, 285-289.
55. Sugino, N., Kashida, S., Karube-Harada, A., Takiguchi, S. and Kato, H. (2002) Expression of vascular endothelial growth factor (VEGF) and its receptors in human endometrium throughout the menstrual cycle and in early pregnancy. Reproduction, 123, 379-387.
56. Torry, D.S., Holt, V.J., Keenan, J.A., Harris, G., Caudle, M.R. and Torry, R.J. (1996) Vascular endothelial growth factor expression in cycling human endometrium. Fertil. Steril., 66, 72-80.
57. Upton, P.D., Austin, C., Taylor, G.M., Nandha, K.A., Clark, A.J., Ghatei, M.A., Bloom, S.R. and Smith, D.M. (1997) Expression of adrenomedullin (ADM) and its binding sites in the rat uterus: Increased number of binding sites and ADM messenger ribonucleic acid in 20-day pregnant rats compared to non-pregnant rats. Endocrinology, 138, 2508-2514.
58. Wildemeersch, D. and Schacht, E. (2001) Treatment of menorrhagia with novel 'frameless' intrauterine levonorgestrel-releasing drug delivery system: A pilot study. Eur. J. Contracept. Reprod. Health Care, 6, 93-101.
59. Zhang, L., Rees, M.C.P. and Bicknell, R. (1995) The isolation and long term culture of normal human endometrial epithelium and stroma: Expression of mRNAs for angiogenic polypeptides basally and on oestrogen challenge. J. Cell Sci., 108, 323-331.
60. Zhao, Y., Hague, S., Manek, S., Zhang, L., Bicknell, R. and Rees, M.C.P. (1998) PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non-oestrogenic mechanism in human endometrium. Oncogene, 16, 409-415.