Melphalan-induced up-regulation of B7-1 surface expression on normal splenic B cells

Cancer Immunology, Immunotherapy

Volumn 52, Issue 3, 2003, Pages 162-170

  Donepudi, Manjula ^a   Jovasevic, Vladimir M ^a   Raychaudhuri, Pradip ^a   Mokyr, Margalit B ^a  

^a NONE   (United States)

Author keywords

B cell; Costimulatory molecule; Gene regulation; Melphalan induced gene expression

Indexed keywords

ACETYLCYSTEINE; DACTINOMYCIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MELPHALAN; TRANSCRIPTION FACTOR AP 1;

ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA SYNTHESIS; SPLEEN CELL; T LYMPHOCYTE; TRANSCRIPTION REGULATION; TUMOR IMMUNITY;

EID: 0037382989     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-002-0345-8     Document Type: Article

References (52)

1. Allison JP, Hurwitz A, Leach DR (1995) Manipulation of co-stimulatory signals to enhance antitumor T-cell responses. Curr Opin Immunol 7:682
2. Arts J, Herr I, Lansink M, Angel P, Kooistra T (1997) Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro. Nucleic Acids Res 15:311
3. Baeuerle PA, Henkel T (1994) Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 12:141
4. Bass KK, Mastrangelo MJ (1998) Immunopotentiation with low-dose cyclophosphamide in the active specific immunotherapy of cancer. Cancer Immunol Immunother 47:1
5. Bocian RC, Ben-Efraim S, Dray S, Mokyr MB (1984) Melphalan-mediated potentiation of antitumor immune responsiveness of immunosuppressed spleen cells from mice bearing a large MOPC-315 tumor. Cancer Immunol Immunother 18:41
6. Bour-Jordan H, Bluestone JA (2002) CD28 function: a balance of costimulatory and regulatory signals. J Clin Immunol 22:1
7. Chambers BJ, Wilson JL, Salcedo M, Markovic K, Bejarano MT, Ljunggren HG (1998) Triggering of natural killer cell mediated cytotoxicity by costimulatory molecules. Curr Top Microbiol Immunol 230:53
8. Chen L, Linsley PS, Hellström KE (1993) Costimulation of T cells for tumor immunity Immunol Today 14:483
9. + T cells to protein antigens in vivo. J Immunol 155:3734
10. + T cells from mice bearing large tumors. Cancer Immunol Immunother 48:153
11. Donepudi M, Raychaudhuri P, Bluestone JA, Mokyr MB (2001) Mechanism of melphalan-induced B7-1 gene expression in P815 tumor cells. J Immunol 166:6491
12. Ehrke MJ, Ryoyama K, Cohen SA (1984) Cellular basis for adriamycin-induced augmentation of cell-mediated cytotoxicity in culture. Cancer Res 44:2497
13. Ehrke MJ, Maccubbin D, Ryoyama K, Cohen SA, Mihich E (1986) Correlation between adriamycin-induced augmentation of interleukin 2 production and of cell-mediated cytotoxicity in mice. Cancer Res 46:54
14. Falcone M, Lee J, Patstone G, Yeung B, Sarvetnick N (1998) B lymphocytes are crucial antigen-presenting cells in pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice. J Immunol 161:1163
15. Freedman AS, Boyd AW, Berribi A, Horowitz JC, Levy DN, Rosen KJ, Daley J, Slaughenhoupt B, Levine H, Nadler LM (1987) Expression of B cell activation antigens on normal and malignant B cells. Leukemia 1:9
16. Freeman GJ, Freedman AS, Segil JM, Lee G, Whitman JF, Nadler LM (1989) B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol 143:2714
17. Gajewski TF, Fallarino F, Uyttenhove C, Boon T (1996) Tumor rejection requires a CTLA-4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization. J Immunol 156:2909
18. Goldfeld AE, Strominger JL, Doyle C (1991) Human tumor necrosis factor-α gene regulation in phorbol ester stimulated T and B cell lines. J Exp Med 174:73
19. Goldfeld AE, Tsai E, Kincaid R, Belshaw PJ, Schrieber SL, Strominger JL, Rao A (1994) Calcineurin mediates human tumor necrosis factor-α gene induction in stimulated T and B cells. J Exp Med 180:763
20. Geldhof AB, Raes G, Bakkus M, Devos S, Thielemans K, De Baetselier P (1995) Expression of B7-1 by highly metastatic mouse T lymphomas induces optimal natural killer cell-mediated cytotoxicity. Cancer Res 55:2730
21. Gorman A, McGowan A, Cotter TG (1997) Role of peroxide and superoxide anion during tumour cell apoptosis. FEBS Lett 404:27
22. Hsing Y, Bishop GA (1999) Requirement for nuclear factor-κB activation by a distinct subset of CD40-mediated effector functions in B lymphocytes. J Immunol 162:2804
23. Huang AY, Bruce AT, Pardoll DM, Levitsky HI (1996) Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo? J Exp Med 183:769
24. Janeway CAJ, Bottomly K (1994) Signals and signs for lymphocyte responses. Cell 76:275
25. Jenkins MK, Johnson JG (1993) Molecules involved in T-cell costimulation. Curr Opin Immunol 5:361
26. Kalinichenko TV, Mokyr MB (1998) Limited importance of CD40/CD40L interaction in the B7-dependent generation of anti-MOPC-315 cytotoxic T lymphocyte activity by tumor bearer splenic cells stimulated in vitro in the presence of tumor necrosis factor. Cancer Immunol Immunother 46:293
27. La Motte RN, Rubin MA, Barr E, Leiden JM, Bluestone JA, Mokyr MB (1996) Therapeutic effectiveness of the immunity elicited by P815 tumor cells engineered to express the B7-2 costimulatory molecule. Cancer Immunol Immunother 42:161
28. + T cell-dependent mechanism. J Immunol 162:4817
29. May M, D'Acquisto F, Madge LA, Glöckner J, Pober S, Ghosh S (2002) Selective inhibition of NF-κB activation by a peptide that blocks the interaction of NEMO with the IκB kinase complex. Science 289:1550
30. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. Embo J 12:2005
31. Meyer M, Pahl HL, Baeuerle PA (1994) Regulation of the transcription factors NF-kappa B and AP-1 by redox changes. Chem Biol Interact 91:91
32. Mihich E, Ehrke MJ (2000) Anticancer drugs plus cytokines: immunodulation based therapies of mouse tumors. Int J Immunopharmacol 22:1077
33. Mokyr MB, Gorelik L (1997) Melphalan as an immunopotentiating agent in cancer therapy. Biotherapy 11:219
34. Morel A, Fernandez N, de La Coste A, Haddada H, Viguier M, Polla BS, Antoine B, Kahn A (1998) Gamma-ray irradiation induces B7.1 costimulatory molecule neoexpression in various murine tumor cells. Cancer Immunol Immunother 46:277
35. Nishio M, Spielman J, Lee RK, Nelson DL, Podack ER (1996) CD80 (B7.1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis. J Immunol 157:4347
36. Osborn L, Kunkel S, Nabe GJ (1989) Tumor necrosis factor alpha and interleukin I stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci USA 86:2336
37. Pahl HL, Baeuerle PA (1994) Oxygen and the control of gene expression. Bioessays 16:497
38. Pinkus R, Weiner LM, Daniel V (1996) Role of oxidants and antioxidants in the induction of AP-1, NF-kappa B, and glutathione S-transferase gene expression. J Biol Chem 271:13422
39. Ranheim EA, Kipps TJ (1993) Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J Exp Med 177:925
40. Selvakumar A, White PC, Dupont B (1993) Genomic organization of the mouse B-lymphocyte activation antigen B7. Immunogenetics 38:292
41. Serreze DV, Fleming SA, Chapman HD, Richard SD, Leiter EH, Tish RM (1998) B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Immunol 161:3912
42. Smyth C, Logan G, Weinberger RP, Rowe PB, Alexander IE, Smythe JA (1998) Identification of a dynamic intracellular reservoir of CD86 protein in peripheral blood monocytes that is not associated with the Golgi complex. J Immunol 160:5390
43. Sojka DK, Donepudi M, Bluestone JA, Mokyr MB (2000) Melphalan and other anticancer modalities up-regulate B7-1 gene expression in tumor cells. J Immunol 164:6230
44. Sojka DK, La Motte RN, Mokyr MB (2000) B7-2 expression on tumor cells is important for the acquisition of CTL activity by spleen cells from low-dose melphalan-treated MOPC-315 tumor cells via a mechanism that requires either B7-1 or B7-2 expression on host antigen-presenting cells. Cancer Immunol Immunother 49:10
45. + T-cells in eradication of a large subcutaneous MOPC-315 tumor following low-dose melphalan therapy. Cancer Res 50:7641
46. + T cells by B7-transfected melanoma cells. Science 259:368
47. Vereecque R, Buffenoir G, Gonzalez R, Cambier N, Hetuin D, Bauters F, Fenaux P, Quesnel B (2000) Gamma-ray irradiation induces B7.I expression in myeloid leukaemic cells. Br J Haematol 108:825
48. Verhasselt V, Vanden Berghe W, Vanderheyde N, Willems F, Haegeman G, Goldman M (1999) N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: association with NF-κB inhibition. J Immunol 162:2569
49. Wu TC, Huang AY, Jaffee EM, Levitsky HI, Pardoll DM (1995) A reassessment of the role of B7-1 expression in tumor rejection. J Exp Med 182:1415
50. Yang G, Mizuno MT, Hellström KK, Chen L (1997) B7-negative versus B7-positive P815 tumor: differential requirements for priming of an antitumor immune response in the lymph nodes. J Immunol 158:851
51. Zhang H, Haasch D, Idler KB, Okasinski GF (1996) Isolation and promoter mapping of the gene encoding murine co-stimulatory factor B7-1. Gene 183:1
52. Zhao J, Freeman GJ, Gray GS, Nadler LM, Glimcher LH (1996) A cell type-specific enhancer in the human B7.1 gene regulated by NF-κB. J Exp Med 183:777