Backbone dynamics of dynein light chains

Cell Motility and the Cytoskeleton

Volumn 54, Issue 4, 2003, Pages 267-273

  Wu, Hongwei ^a   King, Stephen M ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Backbone dynamics; Dynein; Leucine rich repeat; Microtubule; NMR spectroscopy

Indexed keywords

DYNEIN ADENOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN LIGHT CHAIN; LEUCINE;

BINDING SITE; COMPLEX FORMATION; HYDROPHOBICITY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN STRUCTURE; REVIEW; TANDEM REPEAT; X RAY CRYSTALLOGRAPHY;

ANIMALS; CARRIER PROTEINS; CELL MOVEMENT; CILIA; DIMERIZATION; DROSOPHILA PROTEINS; FLAGELLA; HUMANS; LEUCINE; MOLECULAR MOTOR PROTEINS; PROTEIN STRUCTURE, TERTIARY;

EID: 0037381916     PISSN: 08861544     EISSN: None     Source Type: Journal    
DOI: 10.1002/cm.10108     Document Type: Review

References (25)

1. Benashski SE, Patel-King RS, King SM. 1999. Light chain 1 from the Chlamydomonas outer dynein arm is a leucine-rich repeat protein associated with the motor domain of the γ heavy chain. Biochemistry 38:7253-7264.
2. DiBella LM, King SM. 2001. Dynein motors of the Chlamydomonas flagellum. Int Rev Cytol 210:227-268.
3. Dick T, Ray K, Salz HK, Chia W. 1996a. Cytoplasmic dynein (dd1c1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. Mol Cell Biol 16:1966-1977.
4. Dick T, Surana U, Chia W. 1996b. Molecular and genetic characterization of SLC1, a putative Saccharomyces cerevisiae homolog of the metazoan cytoplasmic dynein light chain 1. Mol Gen Genet 251:38-43.
5. Fan J-S, Zhang Q, Tochio H, Li M, Zhang M. 2001. Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain. J Mol Biol 306:97-108.
6. Fan J-S, Zhang Q, Tochio H, Zhang M. 2002. Backbone dynamics of the 8 kDa light chain dimer reveals molecular basis of the protein's functional diversity. J. Biomol NMR 23:103-114.
7. Kajava AV. 1998. Structural diversity of leucine-rich repeat proteins. J Mol Biol 277:519-527.
8. Karki S, Holzbaur EL. 1999. Cytoplasmic dynein and dynactin in cell division and intracellular transport. Curr Opin Cell Biol 11:45-53.
9. King SM. 2002. Dynein Motors: structure, mechanochemistry and regulation. In: Schliwa M, editor. Molecular motors. Weinheim: Wiley-VCH Verlag GmbH, p 45-78.
10. r8,000 and 11,000 outer arm dynein light chains from Chlamydomonas flagella have cytoplasmic homologues. J Biol Chem 270:11445-11452.
11. Kobe B, Deisenhofer J. 1993. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature 366:751-756.
12. Kobe B, Deisenhofer, J. 1996. Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A. J Mol Biol 264:1028-1043.
13. Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J. 1999. Structure of the PIN/LC8 dimer with a bound peptide. Nature Struct Biol 6:735-740.
14. Mok Y-K, Lo KW-H., Zhang M. 2001. Structure of Tctex-1 and its interaction with cytoplasmic dynein intermediate chain. J Biol Chem 276:14067-14074.
15. Pazour GJ, Wilkerson CG, Witman G. B. (1998). A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT). J Cell Biol 141:979-992.
16. Price SR, Evans PR, Nagai K. 1998. Crystal structure of the spliceosomal U2B″-U2A′ protein complex bound to a fragment of U2 small nuclear RNA. Nature 394:645-650.
17. Rittinger K, Walker PA, Eccleston JF, Smerdon SJ, Gamblin SJ. 1997. Structure at 1.165 Å of RhoA and its GTPase-activating protein in complex with a transition state analogue. Nature 389:758-762.
18. Scheffzek K, Ahmadian MR, Kabsch W, Weismuller L, Lautwein A, Schmitz F, Wittinghofer A. 1997. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 277:333-338.
19. Takada S, Kamiya R. 1994. Functional reconstitution of Chlamydomonas outer dynein arms from α, β and γ subunits: requirement for a third factor. J Cell Biol 126:737-745.
20. Tjandra N, Garett DS, Gronenborn AM, Bax A, Clore GM. 1997. Defining long-range order in NMR structure determination from the dependence of heteronuclear relaxation times on rotational diffusion anisotropy. Nature Struct Biol 4:443-449.
21. Tochio H, Ohki S, Zhang Q, Li M, Zhang M. 1998. Solution structure of a protein inhibitor of neuronal nitric oxide synthase. Nature Struct Biol 5:965-969.
22. Wilson MJ, Salata MW, Susalka SJ, Pfister KK. 2001. Light chains of mammalian cytoplasmic dynein: identification and characterization of a family of LC8 light chains. Cell Motil Cytoskeleton 49:229-240.
23. 13C resonance assignments for the Tctex1 dynein light chain from Chlamydomonas flagella. J Biomol NMR 20:89-90.
24. Wu H, Maciejewski MW, Marintchev A, Benashski SE, Mullen GP, King SM. 2000. Solution structure of a dynein motor domain associated light chain. Nature Struct Biol 7:575-579.
25. Wu H, Blackledge M, Maciejewski MW, Mullen GP, King SM. 2003. Relaxation-based structure refinement and backbone molecular dynamics of the dynein motor domain-associated light chain. Biochemistry 42:57-71.