A synthetic predator odor (TMT) enhances conditioned analgesia and fear when paired with a benzodiazepine receptor inverse agonist (FG-7142)

Psychobiology

Volumn 25, Issue 1, 1997, Pages 83-88

  Hotsenpiller, Gregory ^a   Williams, Jon L ^a  

^a KENYON COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 DIHYDRO 2,4,5 TRIMETHYLTHIAZOLINE; BENZODIAZEPINE RECEPTOR INVERSE STIMULATING AGENT; BUTYRIC ACID; N METHYL BETA CARBOLINE 3 CARBOXAMIDE; PHEROMONE; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CONDITIONING; CONTROLLED STUDY; FEAR; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MENTAL STRESS; NEUROPSYCHOLOGY; ODOR; PREDATION; RAT;

EID: 0030899019     PISSN: 08896313     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. BIGGIO, G., CONCAS, A., MELE, S., & CORDA, M. G. (1987). Changes in GABAergic transmission induced by stress, anxiogenic and anxiolytic B-carbolines. Brain Research Bulletin, 19, 301-308.
2. BRETT, R. R., JEDRUSIK, P., LAVERTY, W., & PRATT, J. A. (1995). Continuous exposure to FG 7142: Behavioral sensitization is not accompanied by changes in benzodiazepine/GABA receptor coupling. Journal of Psychopharmacology, 9, 223-227.
3. CRAWLEY, J. N., NINAN, P. T., PICKAR, D., CHROUSOS, G. P., LINNOILA, M., SKOLNICK, P., & PAUL, S. M. (1985). Neuropharmacological antagonism of the beta-carboline-induced "anxiety" response in Rhesus monkeys. Journal of Neuroscience, 5, 477-485.
4. DORROW, R., HOROWSKI, R., PASCHELKE, G., AMIN, M., & BRAESTRUP, C. (1983). Severe anxiety induced by FG 7142, a beta-carboline ligand for benzodiazepine receptors. Lancet, 41, 98-99.
5. DRUGAN, R. C., MAIER, S. F., SKOLNICK, P., PAUL, S. M., & CRAWLEY, J. N. (1985). An anxiogenic benzodiazepine receptor ligand induces learned helplessness. European Journal of Pharmacology, 113, 453-457.
6. DUKA, T., & STEPHENS, D. N. (1986). Potentiation of the propunishment, but not the convulsant action of the B-carboline DMCM by naltrexone. Pharmacology, Biochemistry & Behavior, 25, 595-598.
7. FANSELOW, M. S. (1984). Shock-induced analgesia on the formalin test: Effects of shock severity, naloxone, hypophysectomy, and associative variables. Behavioral Neuroscience, 98, 79-95.
8. FANSELOW, M. S., & BAACKES, M. P. (1982). Conditioned fear-induced opiate analgesia on the formalin test: Evidence for two aversive motivational systems. Learning & Motivation, 13, 200-221.
9. FANSELOW, M. S., & HELMSTETTER, F. J. (1988). Conditioned analgesia, defensive freezing, and benzodiazepines. Behavioral Neuroscience, 102, 233-243.
10. A receptors in fear-related behavior. Behavioral Neuroscience, 106, 336-344.
11. GARBE, C. M., KEMBLE, E. D., & RAWLEIGH, J. M. (1993). Novel odors evoke risk assessment and suppress appetitive behaviors in mice. Aggressive Behavior, 19, 447-454.
12. HELMSTETTER, F. J., CALCAGNETTI, D. J., & FANSELOW, M. S. (1990). The beta-carboline DMCM produces hypoalgesia after central administration. Psychobiology, 18, 293-297.
13. HOLMES, P. V., & DRUGAN, R. C. (1991). Differential effects of anxiogenic central and peripheral benzodiazepine receptor ligands in tests of learning and memory. Psychopharmacology, 104, 249-254.
14. HOTSENPILLER, G. (1995). [Weight gain of activated charcoal as a result of proximal odors]. Unpublished raw data.
15. 1A agonists. Psychobiology, 24, 118-126.
16. INSEL, T. R., NINAN, P. T., ALOI, J., JIMERSON, D. C., SKOLNICK, P., & PAUL, S. M. (1984). A benzodiazepine receptor-mediated model of anxiety: Studies in nonhuman primates and clinical implications. Archives of General Psychiatry, 41, 741-750.
17. KEMBLE, E. D., & GIBSON, B. M. (1992). Avoidance and hypoalgesia induced by novel odors in mice. Psychological Record, 42, 555-563.
18. LEIDENHEIMER, N. J., & SCHECHTER, M. D. (1988). Discriminative stimulus control by the anxiogenic b-carboline FG 7142: Generalization to a physiological stressor. Pharmacology, Biochemistry & Behavior, 30, 351-355.
19. MAIER, S. F. (1986). Stressor controllability and stress-induced analgesia. In D. D. Kelley (Ed.), Stress-induced analgesia (Annals of the New York Academy of Sciences, Vol. 467, pp. 55-71). New York: New York Academy of Sciences.
20. MAIER, S. F., BUSCH, C. R., MASWOOD, S., GRAHN, R. E., & WATKINS, L. R. (1995). The benzodiazepine receptor inverse agonist DMCM microinjected into the region of the dorsal raphe nucleus mimics the effects of inescapable shock. Society for Neuroscience Abstracts, 21, 464.
21. MENDELSON, W. B., CAIN, M., COOK, J. M., PAUL, S. M., & SKOLNICK, P. (1982). Do benzodiazepine receptors play a role in sleep regulation? Studies with the benzodiazepine antagonist, 3-hydroxymethyl-B-carboline (3-HOC). In E. Usdin (Ed.), Beta-carbolines and tetrahydroisoquinolines (pp. 253-261). New York: Alan R. Liss.
22. MENG, I. D., & DRUGAN, R. C. (1993). Sex differences in open field behavior in response to the B-carboline FG 7142 in rats. Physiology & Behavior, 54, 701-705.
23. MINEKA, S., & COOK, M. (1988). Social learning and the acquisition of snake fear in monkeys. In T. R. Zentall & B. G. Galef, Jr. (Eds.), Social learning: Psychological and biological perspectives (pp. 51-73). Hillsdale, NJ: Erlbaum.
24. NINAN, P. T., INSEL, T. M., COHEN, R. M., COOK, J. M., SKOLNICK, P., & PAUL, S. M. (1982). Benzodiazepine receptor-mediated experimental "anxiety" in primates. Science, 218, 1332-1334.
25. PETERSON, C., MAIER, S. F., & SELIGMAN, M. E. P. (1993). Learned helplessness: A theory for the age of personal control. New York: Oxford University Press.
26. ROBINSON, I. (1990). The effect of mink odour on rabbits and small mammals. In D. W. Macdonald, D. Muller-Schwarze, & S. E. Natynczuk (Eds.), Chemical signals in vertebrates (Vol. 5, pp. 566-572). Oxford: Oxford University Press.
27. SCHWERI, M. M., MARTIN, J. V., MENDELSON, W. B., BARRETT, J. E., PAUL, S. M., & SKOLNICK, P. (1983). Pharmacokinetic and pharmacodynamic factors contributing to the convulsant action of beta-carboline-3-carboxylic acid esters. Life Sciences, 33, 1505-1510.
28. THIEBOT, M.-H., SOUBRIE, P., & SANGER, D. (1988). Anxiogenic properties of beta-CCE and FG-7142: A review of promises and pitfalls. Psychopharmacology, 94, 452-463.
29. TSUDA, A., IDA, Y., NISHIMURA, H., & TANAKA, M. (1989). Anxiogenic effects of β-CCE as measured in two different conditioning paradigms. Psychobiology, 17, 202-206.
30. VERNET-MAURY, E. (1980). Trimethylthiazoline in fox feces: A natural alarming substance for the rat. In H. van der Starre (Ed.), Olfaction and taste (Vol. 7, p. 407). Washington, DC: IRL.
31. VERNET-MAURY, E., CONSTANT, B., & CHANEL, J. (1992). Repellent effect of trimethylthiazoline in the wild rat Rattus norvegicus Berkenhout. In R. L. Doty & D. Muller-Schwarze (Eds.), Chemical signals in vertebrates (Vol. 6., pp. 305-310). New York: Plenum.
32. VERNET-MAURY, E., POLAK, E. H., & DEMAEL, A. (1984). Structure-activity relationship of stress-inducing odorants in the rat. Journal of Chemical Ecology, 10, 1007-1018.
33. WILLIAMS, J. L., & GROUX, M. L. (1993). Exposure to various stressors alters preferences for natural odors in rats (Rattus norvegicus). Journal of Comparative Psychology, 107, 39-47.
34. WILLIAMS, J. L., JUST, J. M., & WORLAND, P. D. (1994). Effect of repeated-defeat sessions as a colony intruder on subsequent hypoalgesia and feeding in the rat. Learning & Motivation, 25, 152-174.
35. WILLIAMS, J. L., & SCOTT, D. K. (1989). Influence of conspecific and predatory stressors and their associated odors on defensive burying and freezing responses. Animal Learning & Behavior, 17, 383-393.
36. WILLIAMS, J. L., WORLAND, P. D., & SMITH, M. G. (1990). Defeatinduced hypoalgesia in the rat: Effects of conditioned odors, naltrexone, and extinction. Journal of Experimental Psychology: Animal Behavior Processes, 16, 345-357.