메뉴 건너뛰기




Volumn 48, Issue 4, 2003, Pages 670-676

Expression of Bcl-2 family modulated through p53-dependent pathway in human hepatocellular carcinoma

Author keywords

Apoptosis; Bax; Bcl 2; Bcl xL; Bcl xS; Hepatocellular carcinoma; p21; p53

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BCL XS; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 0037380281     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022816204831     Document Type: Article
Times cited : (31)

References (18)
  • 1
    • 0032895373 scopus 로고    scopus 로고
    • Immunohistochemical evaluation of bcl-2 gene family expression in liver of hepatitis C and cirrhotic patients: A novel mechanism to explain the high incidence of hepatocarcinoma in cirrhotics
    • Frommel TO, Yong S, Zarling EJ: Immunohistochemical evaluation of bcl-2 gene family expression in liver of hepatitis C and cirrhotic patients: a novel mechanism to explain the high incidence of hepatocarcinoma in cirrhotics. Am J Gastroenterol 94:178-182, 1999
    • (1999) Am J Gastroenterol , vol.94 , pp. 178-182
    • Frommel, T.O.1    Yong, S.2    Zarling, E.J.3
  • 2
    • 0030916669 scopus 로고    scopus 로고
    • The proto-oncogene Bcl- 2 and its role in regulating apoptosis
    • Kroemer G: The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nature Med 3:614-620, 1997
    • (1997) Nature Med , vol.3 , pp. 614-620
    • Kroemer, G.1
  • 4
    • 0034950640 scopus 로고    scopus 로고
    • Expression and role of Bcl-xL in human hepatocellular carcinoma
    • Takehara T, Liu X, Fujimoton J, et al: Expression and role of Bcl-xL in human hepatocellular carcinoma. Hepatology 34:55-61, 2001
    • (2001) Hepatology , vol.34 , pp. 55-61
    • Takehara, T.1    Liu, X.2    Fujimoton, J.3
  • 5
    • 0028036895 scopus 로고
    • Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl- 2
    • Krajewiski S, Krajewska M, Shabaik A, et al: Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am J Pathol 145:1323-1336, 1994
    • (1994) Am J Pathol , vol.145 , pp. 1323-1336
    • Krajewiski, S.1    Krajewska, M.2    Shabaik, A.3
  • 6
    • 0028335717 scopus 로고
    • Tumor suppressor p53 is a regulator of bcl- 2 and bax gene expression in vitro and in vivo
    • Miyashita T, Krajewski S, Krajewska M, et al: Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9:1799-1805, 1994
    • (1994) Oncogene , vol.9 , pp. 1799-1805
    • Miyashita, T.1    Krajewski, S.2    Krajewska, M.3
  • 7
    • 0028238213 scopus 로고
    • Immediate early upregulation of bax expression by p53 but not TGF-β: A paradigm for distinct apoptotic pathways
    • Selvakumaran M, Lin HK, Miyashita T, et al: Immediate early upregulation of bax expression by p53 but not TGF-β: a paradigm for distinct apoptotic pathways. Oncogene 9:1791-1798, 1994
    • (1994) Oncogene , vol.9 , pp. 1791-1798
    • Selvakumaran, M.1    Lin, H.K.2    Miyashita, T.3
  • 8
  • 9
    • 0025732215 scopus 로고
    • Mutational hot spot in the p 53 gene in human hepatocellular carcinoma
    • Hsu IC, metcalf RA, Sun T, et al: Mutational hot spot in the p53 gene in human hepatocellular carcinoma. Nature 350:427-428, 1991
    • (1991) Nature , vol.350 , pp. 427-428
    • Hsu, I.C.1    Metcalf, R.A.2    Sun, T.3
  • 10
    • 0025828517 scopus 로고
    • Selective G to T mutations of p 53 gene in hepatocellular carcinoma from southern Africa
    • Bressac B, Kew M, Wands J, et al: Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 35:429-431, 1991
    • (1991) Nature , vol.35 , pp. 429-431
    • Bressac, B.1    Kew, M.2    Wands, J.3
  • 11
    • 0028849274 scopus 로고
    • p21 is necessary for the p53-mediated GI arrest in human cancer cells
    • Waldman T, Kinzler KW, Vogelstein B: p21 is necessary for the p53-mediated GI arrest in human cancer cells. Cancer Res 55:5187-5190, 1995
    • (1995) Cancer Res , vol.55 , pp. 5187-5190
    • Waldman, T.1    Kinzler, K.W.2    Vogelstein, B.3
  • 12
    • 0028820762 scopus 로고
    • The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vitro
    • Yang ZY, Perkins ND, Ohno T, et al: The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vitro. Nature Med 1:1052-1056, 1995
    • (1995) Nature Med , vol.1 , pp. 1052-1056
    • Yang, Z.Y.1    Perkins, N.D.2    Ohno, T.3
  • 13
    • 0034077411 scopus 로고    scopus 로고
    • Reduced p21 WAF1/CIP 1 protein expression is predominatly related to altered p53 in hepatocellular carcinoma
    • Shi YZ, Takayama T, Li X, et al: Reduced p21 WAF1/CIP1 protein expression is predominatly related to altered p53 in hepatocellular carcinoma. Br J Cancer 83:50-55, 2000
    • (2000) Br J Cancer , vol.83 , pp. 50-55
    • Shi, Y.Z.1    Takayama, T.2    Li, X.3
  • 14
    • 0012658343 scopus 로고    scopus 로고
    • p53, p21 and the control of cell proliferation
    • NSB Thomas (ed). Oxford, BIOS Scientific Publishers
    • El-Deity WS: p53, p21 and the control of cell proliferation. In Apoptosis and Cell Cycle Control in Cancer. NSB Thomas (ed). Oxford, BIOS Scientific Publishers, 1996, pp 65-75
    • (1996) Apoptosis and Cell Cycle Control in Cancer , pp. 65-75
    • El-Deity, W.S.1
  • 15
    • 0027258466 scopus 로고
    • Thymocyte apoptosis induced by p53-dependent and -independent pathways
    • Clarke AR, Purdie CA, Harrison DJ, et al: Thymocyte apoptosis induced by p53-dependent and -independent pathways. Nature 362:849-852, 1993
    • (1993) Nature , vol.362 , pp. 849-852
    • Clarke, A.R.1    Purdie, C.A.2    Harrison, D.J.3
  • 16
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Earl Ruley H, Jacks T, et al: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957-967, 1993
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Earl Ruley, H.2    Jacks, T.3
  • 17
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
    • Oltvaj ZN, Milliman CL, Krosmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death. Cell 74:609-619, 1993
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvaj, Z.N.1    Milliman, C.L.2    Krosmeyer, S.J.3
  • 18
    • 0030724069 scopus 로고    scopus 로고
    • Wild-type p53 induces apoptosis in Hep3B through up-regulation of Bax expression
    • Mitry RR, Sarraf CE, Wu CG, et al: Wild-type p53 induces apoptosis in Hep3B through up-regulation of Bax expression. Lab Invest 77:369-378, 1997
    • (1997) Lab Invest , vol.77 , pp. 369-378
    • Mitry, R.R.1    Sarraf, C.E.2    Wu, C.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.